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Editors' Choice

John F. Foley
19 February 2013: ec45.
A peptide that induces autophagy has beneficial effects in cellular responses to viruses and the accumulation of protein aggregates. Abstract »  
Wei Wong
19 February 2013: ec46.
FTO contributes to the ability of mTORC1 to respond to amino acid availability. Abstract »  
Nancy R. Gough
19 February 2013: ec47.
Bacteria use cyclic di-GMP as an allosteric activator of polysaccharide synthesis necessary for biofilm formation. Abstract »  
Kristen L. Mueller
19 February 2013: ec48.
Cyclic GMP-AMP acts as a second messenger that turns on antiviral immunity in response to cytoplasmic DNA. Abstract »  



Jayne S. Danska and Annalisa M. VanHook
19 February 2013: pc6.
Male-type gut microbiota are associated with an increase in testosterone that protects mice from developing type 1 diabetes. Abstract »   Full Text »   Podcast »  


Research Articles

Chrysoula Pitsouli and Norbert Perrimon
19 February 2013: ra12.
Signals converge on the transcription factor Cut to orchestrate tracheal development. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Anja Stirnweiss, Roland Hartig, Steffi Gieseler, Jonathan A. Lindquist, Peter Reichardt, Lars Philipsen, Luca Simeoni, Mateusz Poltorak, Camilla Merten, Werner Zuschratter, Yury Prokazov, Wolfgang Paster, Hannes Stockinger, Thomas Harder, Matthias Gunzer, and Burkhart Schraven
19 February 2013: ra13.
T cell activation involves the conformational activation of the tyrosine kinase Lck. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Dan Y. Gui, Caroline A. Lewis, and Matthew G. Vander Heiden
19 February 2013: pe7.
Regulation of the metabolic enzyme PKM2 enables cells to switch from a growth-promoting to an energy-producing state. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882