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Editors' Choice

Leslie K. Ferrarelli
26 February 2013: ec49.
At cold temperatures, the cation channel TRPA1 extends life span in worms. Abstract »  
Annalisa M. VanHook
26 February 2013: ec50.
A component of the electron transport chain complex I escorts STAT3 into mitochondria. Abstract »  
Nancy R. Gough
26 February 2013: ec51.
Targeting the dimerization interface of Raf disrupts signaling by all but the most active mutants. Abstract »  
Kristen L. Mueller
26 February 2013: ec52.
Caspase-11 triggers cell death in response to bacteria that gain access to the cytosol of macrophages. Abstract »  
John F. Foley
26 February 2013: ec53.
Autophagy is required for the maintenance of antibody production by plasma cells. Abstract »  



Philip D. King, Beth A. Lubeck, and Philip E. Lapinski
26 February 2013: re1.
Mutations in Ras guanosine triphophatase–activating proteins (RasGAPs) cause disease in humans. Gloss »   Abstract »   Full Text »   PDF »  


Research Resources

Sehyun Chae, Byung Yong Ahn, Kyunghee Byun, Young Min Cho, Myeong-Hee Yu, Bonghee Lee, Daehee Hwang, and Kyong Soo Park
26 February 2013: rs4.
Transcriptional profiling and transcription factor matching reveal potential targets for therapies against diseases associated with mitochondrial dysfunction. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Arunachalam Vinayagam, Yanhui Hu, Meghana Kulkarni, Charles Roesel, Richelle Sopko, Stephanie E. Mohr, and Norbert Perrimon
26 February 2013: rs5.
An analysis tool maps network dynamics at the protein complex level in multiple species. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882