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Editors' Choice

Leslie K. Ferrarelli
5 March 2013: ec54.
Serotonin-targeted antidepressants may induce diabetes by disrupting the insulin signaling pathway and inducing cell death in pancreatic β cells. Abstract »  
Annalisa M. VanHook
5 March 2013: ec55.
An atypical protein kinase C promotes growth of basal cell carcinoma cells by stimulating activation of the transcription factor GLI1. Abstract »  
Nancy R. Gough
5 March 2013: ec56.
The Fragile X mental retardation protein interacts with a specific type of potassium channel to enhance the channel’s calcium sensitivity and limit action potential firing. Abstract »  
Kristen L. Mueller
5 March 2013: ec57.
The cytokine interferon-{varepsilon} is expressed in the female reproductive tract and protects against sexually transmitted diseases. Abstract »  
Kristen L. Mueller
5 March 2013: ec58.
In mice, the gut microbiota influences levels of sex hormones and the development of autoimmune disease. Abstract »  
Stella M. Hurtley
5 March 2013: ec59.
Two kinases mediate a partner-changing interlude that prevents chromosome segregation errors in yeast meiosis. Abstract »  
Paula A. Kiberstis
5 March 2013: ec60.
The mutational profiles of meningiomas, a common type of brain tumor, correlate with their anatomical location and clinical status. Abstract »  


Research Articles

Allie H. Grossmann, Jae Hyuk Yoo, James Clancy, Lise K. Sorensen, Alanna Sedgwick, Zongzhong Tong, Kirill Ostanin, Aaron Rogers, Kenneth F. Grossmann, Sheryl R. Tripp, Kirk R. Thomas, Crislyn D’Souza-Schorey, Shannon J. Odelberg, and Dean Y. Li
5 March 2013: ra14.
WNT5A activates ARF6 to liberate β-catenin from adherens junctions, thereby increasing the amount that can mediate gene transcription. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yuki Miyamoto, Tomohiro Torii, Natsuki Yamamori, Toru Ogata, Akito Tanoue, and Junji Yamauchi
5 March 2013: ra15.
The phosphorylation status of Dock6 causes sensory neuron axons to switch from extension to branching. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882