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ONLINE COVER This week features a Research Article that presents flow cytometric and mathematical analyses of the effect of increasing the abundance of the α subunit of the interleukin-2 (IL-2) receptor (IL-2Rα) on the responsiveness of mouse T cells to cytokines of the γc family, which includes IL-2 and IL-7. The data suggest that the increased IL-2Rα abundance decreases the sensitivity of T cells to IL-7 by sequestering the γc subunit away from the IL-7R, rendering it nonfunctional. The image shows an artist's depiction, looking down onto the cell surface, of the differential abundance of functional IL-7Rs (dimers) and IL-2Rs (trimers), both of which contain the γc subunit (red), as a consequence of increased IL-2Rα abundance. [Image: Chris Bickel/AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882