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Editors' Choice

Nancy R. Gough
19 March 2013: ec65.
Activities that stimulate thinking may prevent symptoms of Alzheimer’s disease by blocking the effects of Aβ. Abstract »  
Leslie K. Ferrarelli
19 March 2013: ec66.
Wound healing relies on a posttranscriptional switch to inversely regulate the translation of a microRNA and a protein encoded within a single transcript. Abstract »  
Annalisa M. VanHook
19 March 2013: ec67.
Epidermal growth factor receptor signaling antagonizes Hippo-dependent repression of the transcriptional coactivator Yorkie. Abstract »  
John F. Foley
19 March 2013: ec68.
Loss of the tumor suppressor protein PML sensitizes glioblastoma cells to inhibitors of the mammalian target of rapamycin. Abstract »  
L. Bryan Ray
19 March 2013: ec69.
In addition to its role in stimulating protein and lipid synthesis, the kinase mammalian target of rapamycin stimulates nucleotide biosynthesis. Abstract »  
Pamela J. Hines
19 March 2013: ec70.
In plants, day/night information is communicated from a nuclear-encoded circadian oscillator to the chloroplast. Abstract »  



Ching-Shih Chen and Annalisa M. VanHook
19 March 2013: pc8.
Vitamin E promotes dephosphorylation of the kinase Akt to suppress the growth of prostate cancer cells. Abstract »   Full Text »   Podcast »  


Research Articles

Arti V. Shinde, Rajender K. Motiani, Xuexin Zhang, Iskandar F. Abdullaev, Alejandro P. Adam, José C. González-Cobos, Wei Zhang, Khalid Matrougui, Peter A. Vincent, and Mohamed Trebak
19 March 2013: ra18.
The calcium sensor STIM1 disrupts the endothelial barrier by coupling the thrombin receptor to the actin cytoskeleton. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Po-Hsien Huang, Hsiao-Ching Chuang, Chih-Chien Chou, Huiling Wang, Su-Lin Lee, Hsiao-Ching Yang, Hao-Chieh Chiu, Naval Kapuriya, Dasheng Wang, Samuel K. Kulp, and Ching-Shih Chen
19 March 2013: ra19.
Vitamin E suppresses the proliferation of prostate cancer cells by inhibiting the growth-promoting kinase Akt. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Thomas Gudermann and Dirk Steinritz
19 March 2013: pe8.
STIM1 contributes to disruption of the endothelial barrier through two different mechanisms. Abstract »   Full Text »   PDF »  
Brad S. Rothberg, Youjun Wang, and Donald L. Gill
19 March 2013: pe9.
Crystallographic data enable predictions regarding gating of the store-operated calcium entry channel. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882