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Editors' Choice

Wei Wong
26 March 2013: ec71.
Treatments that target the GTPase RAC1 signaling could be developed as antidepressants. Abstract »  
John F. Foley
26 March 2013: ec72.
Early stages of T cell receptor signaling involve recruitment of the plasma membrane–localized adaptor protein LAT into microclusters. Abstract »  
Nancy R. Gough
26 March 2013: ec73.
A glycosphingolipid functions as an endogenous inhibitor of the TLR4-MD2 complex, which mediates the immune response to bacterially derived lipids. Abstract »  
Kristen L. Mueller
26 March 2013: ec74.
The crystal structure of unbound and ligand-bound Toll-like receptor 8 reveals ligand-induced conformational changes. Abstract »  
Kristen L. Mueller
26 March 2013: ec75.
Disseminated Mycobacterium leprae infection is associated with blockade of the antimicrobial response by type I interferons. Abstract »  
Bryan Ray and Annalisa M. VanHook
26 March 2013: ec76.
New studies elucidate mechanisms of Wnt signaling and implicate spatially restricted Wnt signals in orientation of asymmetric stem cell division. Abstract »  

 

Editorial Guides

Nancy R. Gough
26 March 2013: eg3.
Understanding alterations in signaling networks is key to developing rational, personalized cancer therapies. Abstract »   Full Text »   PDF »  

 

Research Articles

Gregory R. Bean, Yogesh Tengarai Ganesan, Yiyu Dong, Shugaku Takeda, Han Liu, Po M. Chan, Yafen Huang, Lewis A. Chodosh, Gerard P. Zambetti, James J.-D. Hsieh, and Emily H.-Y. Cheng
26 March 2013: ra20.
Combining drugs that inhibit antiapoptotic proteins with oncogenic kinase inhibitors may overcome drug resistance in cancer therapy. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Catherine Hartzell, Olga Ksionda, Ed Lemmens, Kristen Coakley, Ming Yang, Monique Dail, Richard C. Harvey, Christopher Govern, Jeroen Bakker, Tineke L. Lenstra, Kristin Ammon, Anne Boeter, Stuart S. Winter, Mignon Loh, Kevin Shannon, Arup K. Chakraborty, Matthias Wabl, and Jeroen P. Roose
26 March 2013: ra21.
Understanding the signaling mechanisms that can lead to T cell leukemia may enable personalized therapies. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

William G. Cance, Elena Kurenova, Timothy Marlowe, and Vita Golubovskaya
26 March 2013: pe10.
Targeting the scaffold of focal adhesion kinase is a therapeutic opportunity to inhibit signaling pathways selectively in cancer cells. Abstract »   Full Text »   PDF »  
Marie R. Webster and Ashani T. Weeraratna
26 March 2013: pe11.
The repertoire of Wnt receptors and co-receptors in melanoma cells may determine whether β-catenin promotes metastasis. Abstract »   Full Text »   PDF »  
Anne Roulston, William J. Muller, and Gordon C. Shore
26 March 2013: pe12.
Drugs that target oncogenic receptor tyrosine kinases activate parallel signaling pathways that trigger cell death. Abstract »   Full Text »   PDF »  

 

Research Resources

Pedro Casado, Juan-Carlos Rodriguez-Prados, Sabina C. Cosulich, Sylvie Guichard, Bart Vanhaesebroeck, Simon Joel, and Pedro R. Cutillas
26 March 2013: rs6.
Computational analysis of phosphoproteomics data predicts the sensitivity of leukemia cells to kinase inhibitors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882