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ONLINE COVER This week begins a two-issue series that focuses on how increasing our understanding of how signaling pathways are altered in cancer cells will enable researchers to develop more effective therapies. In a Research Article in this issue, Hartzell et al. found that the Ras-activating protein RasGRP1, which promotes leukemogenesis, was increased in abundance in pediatric T cell acute lymphoblastic leukemia/lymphoma (T-ALL) patients. [Image: Jessica Key/iStockphoto]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882