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Editors' Choice

Leslie K. Ferrarelli
2 April 2013: ec77.
Through independent mechanisms, TLR9 increases stress tolerance in nonimmune cells while initiating inflammation in immune cells after tissue injury. Abstract »  
Wei Wong
2 April 2013: ec78.
Agonist-bound β2-adrenergic receptors in endosomes continue to trigger the production of cAMP. Abstract »  
Annalisa M. VanHook
2 April 2013: ec79.
Dying cells release chemotactic cytokines that attract phagocytes. Abstract »  
Stella M. Hurtley
2 April 2013: ec80.
When a daughter cell lets go, the mother cell cuts it loose. Abstract »  



Risheng Xu and Annalisa M. VanHook
2 April 2013: pc9.
A multifunctional protein promotes acetylation and activation of the tumor suppressor p53. Abstract »   Full Text »   Podcast »  


Research Articles

Risheng Xu, Nilkantha Sen, Bindu D. Paul, Adele M. Snowman, Feng Rao, M. Scott Vandiver, Jing Xu, and Solomon H. Snyder
2 April 2013: ra22.
By promoting p53 acetylation and activation, IPMK contributes to DNA damage–induced cell death. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Michael B. Yaffe
2 April 2013: pe13.
Signaling networks may provide greater return for the investment in cancer research. Abstract »   Full Text »   PDF »  



Jianjiong Gao, Bülent Arman Aksoy, Ugur Dogrusoz, Gideon Dresdner, Benjamin Gross, S. Onur Sumer, Yichao Sun, Anders Jacobsen, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, and Nikolaus Schultz
2 April 2013: pl1.
The cBioPortal enables integration, visualization, and analysis of multidimensional cancer genomic and clinical data. Abstract »   Full Text »   PDF »   Supplementary Materials »  


Research Resources

Kim Van Roey, Holger Dinkel, Robert J. Weatheritt, Toby J. Gibson, and Norman E. Davey
2 April 2013: rs7.
A resource centered on short linear motifs provides a repository and exploratory tool for conditional protein interactions. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882