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Editors' Choice

Annalisa M. VanHook
16 April 2013: ec83.
Interstitial fluid pressure induces autocrine proliferative and proinvasive glutamate signaling in some cancer cells. Abstract »  
John F. Foley
16 April 2013: ec84.
The increased abundance of the endoglycosidase heparanase in malignant cells enhances their release of exosomes. Abstract »  
Nancy R. Gough
16 April 2013: ec85.
Two hallmarks of Alzheimer’s disease are connected through a CAMKK2-AMPK pathway. Abstract »  
Nancy R. Gough
16 April 2013: ec86.
Photosynthesis or glucose stimulates TOR signaling to activate the root meristem. Abstract »  
Leslie K. Ferrarelli
16 April 2013: ec87.
The adaptor protein STING may also serve as a sensor in the interferon-mediated response to bacterial infection. Abstract »  
Kristen L. Mueller
16 April 2013: ec88.
Blockade of type I interferons leads to better control of persistent lymphocytic choriomeningitis virus infection. Abstract »  
Annalisa M. VanHook
16 April 2013: ec89.
Asymmetric distribution of membrane components may determine asymmetric signaling and directional migration induced by an electric field. Abstract »  

 

Podcasts

Guanglei Zhuang, Napoleone Ferrara, and Annalisa M. VanHook
16 April 2013: pc10.
Analysis of VEGF signaling identifies potential therapeutic strategies for treating pathological angiogenesis. Abstract »   Full Text »   Podcast »  

 

Research Articles

Crystal S. Conn and Shu-Bing Qian
16 April 2013: ra24.
Inhibition of mTORC1 by rapamycin may promote longevity by increasing the quality of protein synthesis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Guanglei Zhuang, Kebing Yu, Zhaoshi Jiang, Alicia Chung, Jenny Yao, Connie Ha, Karen Toy, Robert Soriano, Benjamin Haley, Elizabeth Blackwood, Deepak Sampath, Carlos Bais, Jennie R. Lill, and Napoleone Ferrara
16 April 2013: ra25.
Pathological angiogenesis mediated by the VEGF receptor could be treated by combining mTOR and PI3K inhibitors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Teaching Resources

Nikhita Gadi, Sage E. Foley, Mark Nowey, and George E. Plopper
16 April 2013: tr2.
Analogies with characters and scenes from a Batman movie illustrate how p53 regulates the cellular response to stress. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Jack D. Thatcher
16 April 2013: tr3.
Animated lessons describe the classes of transport proteins and illustrate mechanisms of transport. Abstract »   Full Text »   PDF »   Animations »  
Jack D. Thatcher
16 April 2013: tr4.
Animated lessons illustrate the permeability of four classes of molecules across the plasma membrane and diffusion between cells through gap junctions. Abstract »   Full Text »   PDF »   Animations »  
Jack D. Thatcher
16 April 2013: tr5.
Animated lessons describe gastric pumps, glucose absorption, and CFTR as examples of coupled systems of transport proteins. Abstract »   Full Text »   PDF »   Animations »  
Jack D. Thatcher
16 April 2013: tr6.
Animated lessons describe how Na+- and K+-dependent adenosine triphosphatase (Na+/K+–ATPase) generates an electrochemical gradient across a membrane and provides two examples of how the energy of charged membranes is utilized. Abstract »   Full Text »   PDF »   Animations »  
Pamela K. Kreeger
16 April 2013: tr7.
Multivariate data and context-dependent signaling can be analyzed with the computational approach of PLSR. Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882