Editors' Choice

Neuroscience
Coordinating Neuronal Development

Nancy R. Gough
18 June 2013: ec136.
Brain stem neurons direct the specification of their spinal cord targets, the motor neurons. Abstract »|  

Neuroscience
Too Much or Too Little

Peter R. Stern
18 June 2013: ec137.
Different concentrations of carbon dioxide activate distinct projection neurons and, hence, elicit different responses. Abstract »|  

Cell Biology
PKA Augments Hippo Signaling

Annalisa M. VanHook
18 June 2013: ec138.
Protein kinase A represses activity of the transcriptional coactivator YAP. Abstract »|  

Aging
Methylation and Methuselah?

Stella M. Hurtley
18 June 2013: ec139.
Reduced protein methyltransferase activity improves progeria-like disease phenotypes. Abstract »|  

Cell Biology
Specifying Substrate Specificity

Wei Wong
18 June 2013: ec140.
Distinct intracellular signaling pathways acting on the substrates of a protease could determine which substrates are cleaved. Abstract »|  

Structural Biology
Almost Open

Nancy R. Gough
18 June 2013: ec141.
Crystal structure analysis reveals that β subunits twist the GIRK2 K⁺ channel into a conformation closer to open. Abstract »|  

Research Articles

Plant Biology
bHLH Transcription Factors That Facilitate K⁺ Uptake During Stomatal Opening Are Repressed by Abscisic Acid Through Phosphorylation

Yohei Takahashi, Yuta Ebisu, Toshinori Kinoshita, Michio Doi, Eiji Okuma, Yoshiyuki Murata, and Ken-ichiro Shimazaki
18 June 2013: ra48.
Decreasing the transcription of genes encoding K⁺ channels contributes to inhibition of stomatal opening in Arabidopsis. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

Biochemistry
Inhibition of TGF-β Signaling at the Nuclear Envelope: Characterization of Interactions Between MAN1, Smad2 and Smad3, and PPM1A

Benjamin Bourgeois, Bernard Gilquin, Carine Tellier-Lebègue, Cecilia Östlund, Wei Wu, Javier Pérez, Perla El Hage, François Lallemand, Howard J. Worman, and Sophie Zinn-Justin
18 June 2013: ra49.
MAN1 at the nuclear envelope may block TGF-β signaling by stimulating dephosphorylation of the Smad transcription factors. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

Perspectives

Posttranslational Modifications
Ubiquitin System: Direct Effects Join the Signaling

Alexander L. Chernorudskiy and Murat R. Gainullin
18 June 2013: pe22.
By sterically altering protein-protein interactions, ubiquitin modification can directly affect protein function. Abstract »|   Full Text »|   PDF »|