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Editors' Choice

John F. Foley
15 April 2014: ec95.
Blocking interleukin-21 signaling may alleviate the tissue damage caused by T cells that infiltrate the brain early after ischemic stroke. Abstract »  
Stella M. Hurtley
15 April 2014: ec96.
Mitochondria lacking a Parkinson’s disease–associated kinase harbor a functionally important phosphorylation defect. Abstract »  
Annalisa M. VanHook
15 April 2014: ec97.
A pathogenic fungus activates two C-type lectin receptors to skew the T cell response to one favorable to infection. Abstract »  
Nancy R. Gough
15 April 2014: ec98.
Hematopoietic stem and progenitor cells and mesenchymal stromal cells in the bone marrow use cytokines to respond to an acute need for more myeloid cells. Abstract »  
Jason D. Berndt
15 April 2014: ec99.
NCOA4 acts as a cargo adaptor protein to enable selective autophagy of ferritin, thereby regulating iron bioavailability. Abstract »  
Leslie K. Ferrarelli
15 April 2014: ec100.
Isolated nuclei can directly sense mechanical force and stimulate the phosphorylation of a nuclear membrane protein. Abstract »  
Guy Riddihough
15 April 2014: ec101.
Blocking two crucial repair factors prevents DNA repair during mitosis, which saves the cell from catastrophic chromosome fusions. Abstract »  
Pamela Hines
15 April 2014: ec102.
Within plant seeds, signaling functions from the endosperm regulate development of the embryonic plant suspensor. Abstract »  
Laura Zahn
15 April 2014: ec103.
Guilt by association helps identify the chemogenomic signatures of compounds targeting yeast genes. Abstract »  
Leslie K. Ferrarelli
15 April 2014: ec104.
Interactions with extracellular matrix alter dynamic transcriptional circuits in a cultured breast epithelial cell line, resulting in the appearance of cellular heterogeneity resembling that seen in breast tumors. Abstract »  



Ann-Kathrin Eisfeld, Albert de la Chapelle, and Annalisa M. VanHook
15 April 2014: pc10.
An oncogenic microRNA drives leukemia progression by repressing apoptosis. Abstract »   Full Text »   Podcast »  


Research Articles

María Barreira, Salvatore Fabbiano, José R. Couceiro, Eva Torreira, Jorge L. Martínez-Torrecuadrada, Guillermo Montoya, Oscar Llorca, and Xosé R. Bustelo
15 April 2014: ra35.
An intramolecular double-lock system prevents spurious activation of a protein involved in lymphocyte development and cancer. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ann-Kathrin Eisfeld, Sebastian Schwind, Ravi Patel, Xiaomeng Huang, Ramasamy Santhanam, Christopher J. Walker, Joseph Markowitz, Kevin W. Hoag, Tiina M. Jarvinen, Benjamin Leffel, Danilo Perrotti, William E. Carson, III, Guido Marcucci, Clara D. Bloomfield, and Albert de la Chapelle
15 April 2014: ra36.
Oncogenic microRNA-3151 interferes with the p53-mediated apoptosis pathway to produce more severe leukemia. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882