D

DAG:

stands for diacylglycerol; also known as 1,2-diacylglycerol; an intracellular signaling lipid produced by hydrolysis of membrane lipids; Connections Map Component -- 1,2-Diacylglycerol

DAPI:

stands for 4′,6-diamidino-2-phenylindole; a dye that binds nucleic acid and is used to label nuclei

DARK:

stands for Drosophila Apaf-1 related killer, part of a complex that activates the initiator caspase DRONC, which leads to apoptosis

DARPP-32:

stands for dopamine- and an adenosine 3′,5′-monophosphate (cAMP)-regulated phospho-protein of 32 kilodaltons; cytosolic protein that has been implicated in the regulation of kinase-phosphatase signaling cascades that are modulated by dopamine, glutamate and serotonin

DCP-1:

stands for Drosophila caspase 1, an effector caspase involved in apoptosis, is similar in sequence to mammalian caspase-3

DD:

stands for death domain; Connections Map Component -- Fas-associated protein with death domain

DDR:

stands for discoidin domain receptors; Connections Map Component -- Receptor tyrosine protein kinase

DED:

stands for death effector domain; Connections Map Component -- Death effector domain-containing DNA binding protein

DGPP:

stands for diacylglycerol pyrophosphate

DHA:

stands for docosahexaenoic acid; an n-3 polyunsaturated fatty acid

DIAP1:

stands for Drosophila inhibitor of apoptosis protein 1, a fly protein that inhibits the activity of the initiator caspase DRONC and the effector caspases DRICE and DCP-1

DISC:

stands for death-inducing signaling complex; a protein complex that is initiated by binding of Fas ligand to its receptor, which ultimately triggers apoptosis

Dkk:

stands for Dickkopf; an inhibitor of Wnt signaling; Connections Map Component -- Dickkopf

DLK:

stands for dual-leucine-zipper-bearing kinases, a class of mixed lineage kinases (MLKs); Connections Map Components -- Mitogen-activated protein kinase kinase kinase 12 | Mitogen-activated protein kinase kinase kinases

DLP1:

stands for dynamin-like protein 1; member of the dynamin family of large GTPases

DMEM:

stands for Dulbecco's Modified Eagle's Medium

Dpp:

stands for decapentaplegic; a member of the bone morphogenetic protein family

DRAM:

stands for damage-regulated autophagy modulator; a lysosomal transmembrane protein that is involved in autophagy and contributes to p53-mediated cell death

DRASIC:

stands for dorsal root acid sensing ion channel; a cation channel that has been implicated in the detection of cutaneous touch

DREDD:

stands for death related CED-3/Nedd2-like protein; a caspase in Drosophila melanogaster that may not be critical for apoptosis, but appears to be involved in innate immunity and sperm differentiation

DRG:

stands for dorsal root ganglion

DRICE:

stands for Drosophila ICE, which is a fly homolog of the interleukin-1β converting enzyme (ICE) and may be an effector caspase in apoptosis

DRONC:

stands for Drosophila Nedd2-like caspase, a cysteine protease that participates in apoptosis and is the only initiator caspase in flies

Drp1:

stands for dynamin-related protein1; a protein implicated in the regulation of mitochondrial morphology

dsRBD:

stands for double-stranded RNA binding domain; Connections Map Component -- Ubiquitin-activating enzyme E1-like