Table 1 Drugs targeting the UPR.
Names, structures, and target of molecules identified to target directly the ATF6 (green), IRE1 (pink), or PERK (yellow) pathways. All the molecules indicated are inhibitors except for compounds 147 and 263 that activate ATF6.
| Pathway | Name | Structure | Target | Reference |
| ATF6 | 16F16 |  | PDI | (58) |
| Ceapins |  | ATF6 | (126, 127) | |
| Compound 147 |  | Activators of ATF6 | (128) | |
| Compound 263 |  | |||
| IRE1 | 4μ8c |  | IRE1 RNase | (129) |
| MKC analogs |  | IRE1 RNase | (130–133) | |
| 3-Ethoxy-5,6- dibromosalicylaldehyde |  | IRE1 RNase | (130) | |
| KIRA6 |  | IRE1 kinase | (134) | |
| STF-083010 |  | IRE1 RNase | (135) | |
| Compound 3 |  | IRE1 kinase | (136) | |
| PERK | GSK2656157 |  | PERK | (44) |
| ISRIB |  | eIF2β | (137) | |
| Salubrinal |  | GADD34 (PP1c) | (138) | |
| Guanabenz |  | GADD34 (PP1c) | (139) | |
| Sephin 1/IFB-088 |  | GADD34 (PP1c) | (140) |