Table 1 Natural ligands, expression profiles, and functions of hemITAM receptors.

HemITAM receptors are C-type lectin-like receptors (CTLRs) that are encoded by genes clustered together in the natural killer gene complex (NKC), which includes the Dectin-1 cluster and members of the NKRP1 receptor family. The expression profile for each receptor is indicated for both mice (m) and humans (h). DC, dendritic cell; ROS, reactive oxygen species; TEM cells, effector memory T cells; TLR, Toll-like receptor.

ReceptorLigandExpressionFunction
Dectin-1 cluster
CLEC-2Rhodocytin
Podoplanin
m: platelets, neutrophils, monocytes,
macrophages, DC, NK
Platelet aggregation
Modulation of TLR signaling
h: platelets, liver-resident Kupffer cells
Dectin-1β-1,3-Glucan
Undefined cellular ligand
m: DC, monocytes, macrophages,
neutrophils, γδ T cells
Phagocytosis
ROS production
Cytokine production in synergy with TLR2
DC adaptation for priming of CD8 T cells
Leukotriene production
h: DC, monocytes, macrophages, neutrophils,
γδ T cells, B cells, eosinophils, mast cells
DNGR-1F-actinm: CD8α+ DC, plasmacytoid DCCross-presentation of dead cell–associated antigens
h: BDCA3+ DC
NKRP1 receptors
NKp80AICLm: absent in rodentsCytotoxicity
Cytokine production
h: NK cells, TEM cells
NKp65KACLm: absent in rodentsCytotoxicity
Cytokine production
h: NK-92