Table 4 Bone formation parameters in femurs from WT versus ROKO and from WT-HA-PTPROt versus Y399F-HA-PTPROt mice.

Parameters shown are BFR/BS (bone formation rate normalized to bone surface), N.Ob/B.Pm (number of osteoblasts normalized to bone perimeter), Ob.S/BS (osteoblast surface normalized to bone surface), and N.Ot/B.Ar (number of osteocytes normalized to bone area). n = 7 or 8 male mice per genotype, aged 2 months. Data are means ± SD and were analyzed by two-tailed Student’s t test. NS, not significant.

GenotypeSexBFR/BS
(μm3/μm2 per day)
N.Ob/B.Pm
(/μm)
Ob.S/BS
(%)
N.Ot/B.Ar
(/μm2)
WTM0.827 ± 0.4576.39 ± 1.993.74 ± 1.35797.1 ± 109.6
ROKOM0.965 ± 0.1658.04 ± 2.764.84 ± 1.54852.1 ± 180.5
P valueNSNSNSNS
WT-HAM1.323 ± 0.4994.84 ± 2.422.84 ± 1.30797.5 ± 255.2
Y399F-HAM1.056 ± 0.5447.18 ± 2.103.70 ± 0.66717.6 ± 224.2
P valueNSNSNSNS