Table 2 μCT analysis of tibiae from WT-HA-PTPROt (WT-HA) and Y399F-HA-PTPROt (Y399F-HA) mice.

Parameters shown are BV/TV (trabecular bone volume as percentage of total volume), Tb.Th (trabecular thickness), Tb.Sp (trabecular separation), Tb.N (trabecular number), and tibial length. n = 6 mice of each sex per genotype, aged 2 months. Data are means ± SD and were analyzed by unpaired, two-tailed Student’s t test. Y399F-HA-PTPROt data are from mouse line 8; WT-HA-PTPROt data are combined from mouse lines 2 and 3. See table S1 for a similar comparison to Y399F-HA-PTPROt mouse line 16.

GenotypeSexBV/TV
(%)
Tb.Th
(μm)
Tb.Sp
(μm)
Tb.N
(mm−1)
Length
(mm)
WT-HAM15.0 ± 2.022.8 ± 2.1127.3 ± 22.76.77 ± 1.0317.43 ± 0.15
Y399F-HAM22.0 ± 2.426.1 ± 2.498.4 ± 20.18.17 ± 1.1617.47 ± 0.19
P value0.0240.0160.0420.051NS
WT-HAF12.3 ± 2.524.2 ± 0.8175.0 ± 38.65.18 ± 1.0916.45 ± 0.29
Y399F-HAF18.6 ± 4.425.5 ± 2.7114.4 ± 21.27.30 ± 1.1916.98 ± 0.13
P value0.013NS0.0070.0090.002