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In the Current Issue 22 April 2014 (Issue 322)

Nucleocytoskeletal activation of T cells

Nucleocytoskeletal activation of T cells

Research Articles

Nuclear Envelope Lamin-A Couples Actin Dynamics with Immunological Synapse Architecture and T Cell Activation
José M. González-Granado, Carlos Silvestre-Roig, Vera Rocha-Perugini, Laia Trigueros-Motos, Danay Cibrián, Giulia Morlino, Marta Blanco-Berrocal, Fernando G. Osorio, José M. P. Freije, Carlos López-Otín, Francisco Sánchez-Madrid, and Vicente Andrés
Editor's Summary  |  Abstract  |  Full Text  |  PDF  |  Supplementary Materials

Dynamic Reprogramming of Signaling Upon Met Inhibition Reveals a Mechanism of Drug Resistance in Gastric Cancer
Andrea Z. Lai, Sean Cory, Hong Zhao, Mathieu Gigoux, Anie Monast, Marie-Christine Guiot, Sidong Huang, Ali Tofigh, Crista Thompson, Monica Naujokas, Victoria A. Marcus, Nicholas Bertos, Bita Sehat, Rushika M. Perera, Emily S. Bell, Brent D. G. Page, Patrick T. Gunning, Lorenzo E. Ferri, Michael Hallett, and Morag Park
Editor's Summary  |  Abstract  |  Full Text  |  PDF  |  Supplementary Materials

Podcast

Science Signaling Podcast: 22 April 2014
José María González-Granado, Francisco Sánchez-Madrid, Vicente Andrés, and Annalisa M. VanHook
Abstract  |  Full Text  |  Podcast

Editors' Choice

Sabotaging Immunosurveillance
P. Vantourout et al., Sci. Transl. Med. 6, 231ra49 (2014).
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Tumor-Induced STAT3 Signaling in Myeloid Cells Impairs Dendritic Cell Generation by Decreasing PKCβII Abundance
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Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus
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