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Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research in other journals.

Neuroscience
From PINK1 to Parkin to Mitophagy
Elizabeth M. Adler (9 February 2010)
Sci. Signal. 3 (108), ec49. [DOI: 10.1126/scisignal.2108ec49]
Parkin-dependent ubiquitylation of VDAC1 links PINK1 activity to autophagy of dysfunctional mitochondria. Abstract »  
Development
BMPs Rescue Regeneration
Annalisa M. VanHook (9 February 2010)
Sci. Signal. 3 (108), ec48. [DOI: 10.1126/scisignal.3108ec48]
BMPs can induce redeployment of the developmental program to restore regenerative potential in the mouse digit tip. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues.

Immunology
Focus Issue: External and Internal Regulators of Immune Responses
John F. Foley and Nancy R. Gough (19 January 2010)
Sci. Signal. 3 (105), eg2. [DOI: 10.1126/scisignal.3105eg2]
Host defense mechanisms are modulated by host-derived and pathogen-derived factors. Abstract »   Full Text »   PDF »  
Cell Biology
2009: Signaling Breakthroughs of the Year
Elizabeth M. Adler (5 January 2010)
Sci. Signal. 3 (103), eg1. [DOI: 10.1126/scisignal.3103eg1]
This year's signaling breakthroughs emphasize the importance of looking beyond linear signaling pathways. Abstract »   Full Text »   PDF »  

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ResearchPeer-reviewed original research published in Science Signaling.

Cancer
ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway
Hsu-Ping Kuo, Dung-Fang Lee, Chun-Te Chen, Mo Liu, Chao-Kai Chou, Hong-Jen Lee, Yi Du, Xiaoming Xie, Yongkun Wei, Weiya Xia, Zhang Weihua, Jer-Yen Yang, Chia-Jui Yen, Tzu-Hsuan Huang, Minjia Tan, Gang Xing, Yingming Zhao, Chien-Hsing Lin, Shih-Feng Tsai, Isaiah J. Fidler, and Mien-Chie Hung (9 February 2010)
Sci. Signal. 3 (108), ra9. [DOI: 10.1126/scisignal.2000590]
Acetylation by ARD1 of an inhibitor of mammalian target of rapamycin may inhibit cancer growth. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Biochemistry
SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor
Bita Sehat, Ali Tofigh, Yingbo Lin, Eric Trocme, Ulrika Liljedahl, Jens Lagergren, and Olle Larsson (9 February 2010)
Sci. Signal. 3 (108), ra10. [DOI: 10.1126/scisignal.2000628]
Attachment of SUMO lets insulin-like growth factor receptors act as transcriptional regulators in the nucleus. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books.

Noncoding RNA
Glucocorticoid Receptor DNA Binding Decoy Is a Gas
Michael J. Garabedian and Susan K. Logan (9 February 2010)
Sci. Signal. 3 (108), pe5. [DOI: 10.1126/scisignal.3108pe5]
By mimicking a DNA response element, a noncoding RNA inhibits glucocorticoid receptor activity. Abstract »   Full Text »   PDF »  
Cell Cycle
Proteomics Modifies Our Understanding of Cell Cycle Complexity
Mark C. Hall (26 January 2010)
Sci. Signal. 3 (106), pe4. [DOI: 10.1126/scisignal.3106pe4]
Thousands of modified proteins were revealed in global cell cycle studies of phosphorylation and O-GlycNAcylation. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research.

Dendritic Cells
What Is the Function of the Dendritic Cell Side of the Immunological Synapse?
Jose Luis Rodriguez-Fernandez, Lorena Riol-Blanco, and Cristina Delgado-Martin (19 January 2010)
Sci. Signal. 3 (105), re2. [DOI: 10.1126/scisignal.3105re2]
The immunological synapse organizes signaling responses in dendritic cells as well as in T cells. Abstract »   Gloss »   Full Text »   PDF »  
ATP Signaling
Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation
Ross Corriden and Paul A. Insel (12 January 2010)
Sci. Signal. 3 (104), re1. [DOI: 10.1126/scisignal.3104re1]
Responses to ATP play an important role in regulating the signaling and function of a diverse array of cells and tissues. Abstract »   Gloss »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research.

Immunology
To Be {gamma}{delta} or Not to Be {gamma}{delta}? Signaling Pathways in {alpha}β Versus {gamma}{delta} T Cell Maturation
Julia K. Archbold (8 December 2009)
Sci. Signal. 2 (100), jc2. [DOI: 10.1126/scisignal.2100jc2]
The role of Notch signaling in human T cell maturation is substantially different from that in the mouse. Abstract »   Full Text »   PDF »  
Immunology
Drosophila Toll Pathway: The New Model
Yashwanth Ashok (6 January 2009)
Sci. Signal. 2 (52), jc1. [DOI: 10.1126/scisignal.252jc1]
New data has led to reevaluation of the proteolytic cascades that activate Toll in flies. Abstract »   Full Text »   PDF »  

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ProtocolsDetailed methods and troubleshooting tips for researchers.

Biochemistry
Quantitative Analysis of Protein-Lipid Interactions Using Tryptophan Fluorescence
Catherine A. Kraft, Jose Luis Garrido, Luis Leiva-Vega, and Guillermo Romero (1 December 2009)
Sci. Signal. 2 (99), pl4. [DOI: 10.1126/scisignal.299pl4]
The intrinsic fluorescence of tryptophan can be used to quantify the interaction between proteins and lipids. Abstract »   Full Text »   PDF »  
Cell Biology
Analysis of Signaling Events by Dynamic Phosphoflow Cytometry
Guylene Firaguay and Jacques A. Nunes (1 September 2009)
Sci. Signal. 2 (86), pl3. [DOI: 10.1126/scisignal.286pl3]
State-specific antibodies combined with flow cytometry detect the activity of signaling pathways. Abstract »   Full Text »   PDF »  

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PreviewAbstracts of upcoming articles and resources.

Jasmonate Biochemical Pathway
Aurelie Gfeller, Lucie Dubugnon, Robin Liechti, and Edward E. Farmer
Preview published online February 9, 2010, 10.1126/scisignal.3109cm3
   Abstract »
Arabidopsis Jasmonate Signaling Pathway
Aurelie Gfeller, Robin Liechti, and Edward E. Farmer
Preview published online February 9, 2010, 10.1126/scisignal.3109cm4
   Abstract »

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics.

Response to "Shaky Ground for Lysosome-Dependent Membrane Repair"
Norma W. Andrews (4 October 2005)
Sci. STKE 2005 (304), lc2. [DOI: 10.1126/stke.3042005lc2]
Abstract »   Full Text »   PDF »  
Shaky Ground for Lysosome-Dependent Membrane Repair
Richard A. Steinhardt (4 October 2005)
Sci. STKE 2005 (304), lc1. [DOI: 10.1126/stke.3042005lc1]
Abstract »   Full Text »   PDF »  

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ErrataCorrections to articles and resources.

A Correction to the Research Article Titled: "Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction" by A. Bertotti, M. F. Burbridge, S. Gastaldi, F. Galimi, D. Torti, E. Medico, S. Giordano, S. Corso, G. Rolland-Valognes, B. P. Lockhart, J. A. Hickman, P. M. Comoglio, L. Trusolino
(22 December 2009)
Sci. Signal. 2 (102), er11. [DOI: 10.1126/scisignal.2102er11]
Full Text »   PDF »  
A Correction to the Perspective Titled: "A New Mechanism of Phosphoregulation in Signal Transduction Pathways" by K. Jung and H. Jung
(8 December 2009)
Sci. Signal. 2 (100), er10. [DOI: 10.1126/scisignal.2100er10]
Full Text »   PDF »  

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Virtual JournalA collection of cell signaling articles from participating publishers, updated daily.

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