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Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research published in other journals

Microbiology
Stress Inside Out
Stella M. Hurtley (21 May 2013)
Sci. Signal. 6 (276), ec117. [DOI: 10.1126/scisignal.2004334]
Gram-negative bacteria monitor lipopolysaccharide and outer-membrane protein status to detect and respond to problems. Abstract »  
Cell Biology
Nuclear Actin in Action
Stella M. Hurtley (21 May 2013)
Sci. Signal. 6 (276), ec116. [DOI: 10.1126/scisignal.2004335]
A dynamic polymeric actin structure inside the nucleus is part of the serum response in mammalian tissue culture cells. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues

Cancer
Focus Issue: From Genomic Mutations to Oncogenic Pathways
Nancy R. Gough (26 March 2013)
Sci. Signal. 6 (268), eg3. [DOI: 10.1126/scisignal.2004149]
Understanding alterations in signaling networks is key to developing rational, personalized cancer therapies. Abstract »   Full Text »   PDF »  
Immunology
Focus Issue: Understanding Mechanisms of Inflammation
John F. Foley (15 January 2013)
Sci. Signal. 6 (258), eg2. [DOI: 10.1126/scisignal.2003938]
Inflammatory responses can be both beneficial and detrimental. Abstract »   Full Text »   PDF »  

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Research ArticlesPeer-reviewed original research providing new insights into signal transduction

Evolution
Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways
Jishnu Das, Tommy V. Vo, Xiaomu Wei, Joseph C. Mellor, Virginia Tong, Andrew G. Degatano, Xiujuan Wang, Lihua Wang, Nicolas A. Cordero, Nathan Kruer-Zerhusen, Akihisa Matsuyama, Jeffrey A. Pleiss, Steven M. Lipkin, Minoru Yoshida, Frederick P. Roth, and Haiyuan Yu (21 May 2013)
Sci. Signal. 6 (276), ra38. [DOI: 10.1126/scisignal.2003350]
Comparing protein-interaction networks of two species of yeast suggests that network rewiring may enable environmental adaptation. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
G Proteins
Eukaryotic G Protein Signaling Evolved to Require G Protein–Coupled Receptors for Activation
William Bradford, Adam Buckholz, John Morton, Collin Price, Alan M. Jones, and Daisuke Urano (21 May 2013)
Sci. Signal. 6 (276), ra37. [DOI: 10.1126/scisignal.2003768]
As eukaryotic organisms evolved, their Gα proteins switched from being self-activating to requiring an activating receptor. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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Research ResourcesPeer-reviewed original research reporting signaling-relevant tools, techniques, and databases

Systems Biology
Elucidating Human Phosphatase-Substrate Networks
Xun Li, Matthias Wilmanns, Janet Thornton, and Maja Köhn (14 May 2013)
Sci. Signal. 6 (275), rs10. [DOI: 10.1126/scisignal.2003203]
An online database provides an analysis of human phosphatases and their substrates. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
DNA Damage
Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response
Vincentius A. Halim, Mónica Alvarez-Fernández, Yan Juan Xu, Melinda Aprelia, Henk W. P. van den Toorn, Albert J. R. Heck, Shabaz Mohammed, and René H. Medema (23 April 2013)
Sci. Signal. 6 (272), rs9. [DOI: 10.1126/scisignal.2003664]
Cells arrested by damaged DNA need astrin to enable the cell cycle to resume. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books

Developmental Biology
Understanding the Determinants of Notch Interactions with Its Ligands
Jose F. de Celis (21 May 2013)
Sci. Signal. 6 (276), pe19. [DOI: 10.1126/scisignal.2004079]
Multiple regulatory events govern Notch interactions and response to its ligands. Abstract »   Full Text »   PDF »  
Developmental Biology
A Role for Hipk in the Hippo Pathway
Emad Heidary Arash and Liliana Attisano (14 May 2013)
Sci. Signal. 6 (275), pe18. [DOI: 10.1126/scisignal.2004259]
The kinase HIPK enhances growth by promoting the activity of the transcriptional regulators of the Hippo pathway. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research

Cell Biology
Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage
Tobias Langenhan, Gabriela Aust, and Jörg Hamann (21 May 2013)
Sci. Signal. 6 (276), re3. [DOI: 10.1126/scisignal.2003825]
Emerging insight on the structural and functional versatility of Adhesion-GPCRs draws a fascinating picture of the multiple signals these molecules transmit. Abstract »   Gloss »   Full Text »   PDF »  
Physiology
Signaling Mechanisms in Mammalian Myoblast Fusion
Sajedah M. Hindi, Marjan M. Tajrishi, and Ashok Kumar (23 April 2013)
Sci. Signal. 6 (272), re2. [DOI: 10.1126/scisignal.2003832]
A number of signaling pathways coordinate the development and repair of muscle fibers. Abstract »   Gloss »   Full Text »   PDF »  

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Connections Map Overviews

Plant Biology
Arabidopsis Jasmonate Signaling Pathway
Aurélie Gfeller, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm4. [DOI: 10.1126/scisignal.3109cm4]
Jasmonates regulate various aspects of physiology and development in Arabidopsis thaliana. Abstract »   Full Text »   PDF »  
Plant Biology
Jasmonate Biochemical Pathway
Aurélie Gfeller, Lucie Dubugnon, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm3. [DOI: 10.1126/scisignal.3109cm3]
Jasmonates are potent physiological and developmental regulators synthesized from fatty acid precursors. Abstract »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research

Computational Biology
Decoding the Language of Phosphorylation Site Dynamics
Lily A. Chylek (7 May 2013)
Sci. Signal. 6 (274), jc2. [DOI: 10.1126/scisignal.2004061]
Computational modeling sheds light on the interplay of phosphorylation and diffusion in cell signaling. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Neuroscience
Neuregulin-1 Type I: A Hidden Power Within Schwann Cells for Triggering Peripheral Nerve Remyelination
Anand Krishnan (9 April 2013)
Sci. Signal. 6 (270), jc1. [DOI: 10.1126/scisignal.2003945]
Loss of axonal contact stimulates Schwann cells to produce an autocrine signal that promotes remyelination. Abstract »   Full Text »   PDF »  

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ProtocolsDetailed methods and troubleshooting tips for researchers

Cancer
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Jianjiong Gao, Bülent Arman Aksoy, Ugur Dogrusoz, Gideon Dresdner, Benjamin Gross, S. Onur Sumer, Yichao Sun, Anders Jacobsen, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, and Nikolaus Schultz (2 April 2013)
Sci. Signal. 6 (269), pl1. [DOI: 10.1126/scisignal.2004088]
The cBioPortal enables integration, visualization, and analysis of multidimensional cancer genomic and clinical data. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Phosphoproteomics
Labeling and Identification of Direct Kinase Substrates
Scott M. Carlson and Forest M. White (5 June 2012)
Sci. Signal. 5 (227), pl3. [DOI: 10.1126/scisignal.2002568]
A strategy that uses analog-sensitive kinases enables the identification of low-abundance kinase substrates. Abstract »   Full Text »   PDF »  

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PreviewAbstracts of upcoming articles and resources

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics

Immunology
Comment on "Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling"
Barbara Burtness, Shanthi Marur, Julie E. Bauman, Erica A. Golemis, Ranee Mehra, and Steven J. Cohen (11 December 2012)
Sci. Signal. 5 (254), lc5. [DOI: 10.1126/scisignal.2003734]
Targeted inhibitors used in cancer treatments may have adverse effects on immune responses. Abstract »   Full Text »   PDF »  
Cell Biology
Response to Comment on "A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation": Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool
Piero Dalle Pezze, Annika G. Sonntag, Daryl P. Shanley, and Kathrin Thedieck (10 July 2012)
Sci. Signal. 5 (232), lc4. [DOI: 10.1126/scisignal.2003224]
Dalle Pezze et al. respond to criticisms regarding the specificity of phosphorylation of Ser2481 of mTOR as a specific readout of mTORC2 activity. Abstract »   Full Text »   PDF »  

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ErrataCorrections to articles and resources

A Correction to the Perspective Titled: "STIMulating Stress Fibers in Endothelial Cells" by T. Gudermann and D. Steinritz
(7 May 2013)
Sci. Signal. 6 (274), er2. [DOI: 10.1126/scisignal.6274er2]
An error in the figure of the representation of the TRPC channel is corrected. Full Text »   PDF »  
A Correction to the Research Article Titled: "Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death" by R. Xu, N. Sen, B. D. Paul, A. M. Snowman, F. Rao, M. S. Vandiver, J. Xu, S. H. Snyder
(30 April 2013)
Sci. Signal. 6 (273), er1. [DOI: 10.1126/scisignal.6273er1]
An error in immunoblotting data in Fig. 5C is corrected. Full Text »   PDF »  

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Virtual JournalA collection of cell signaling articles from participating publishers, updated daily

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