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Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research published in other journals

Cell Biology
Endocytotic Notch Signal
L. Bryan Ray (27 July 2010)
Sci. Signal. 3 (132), ec235. [DOI: 10.1126/scisignal.3132ec235]
Low-density lipoprotein receptor–related protein-1 promotes endocytosis that influences non–cell autonomous Notch signaling. Abstract »  
RNA Splicing
Making the Final Cut
Helen Pickersgill (27 July 2010)
Sci. Signal. 3 (132), ec234. [DOI: 10.1126/scisignal.3132ec234]
Network modeling reveals an RNA splicing network in the brain and uncovers complex mechanisms of regulation. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues

Evolution
Focus Issue: The Evolution of Complexity
Nancy R. Gough and Wei Wong (29 June 2010)
Sci. Signal. 3 (128), eg5. [DOI: 10.1126/scisignal.3128eg5]
With the wealth of data in genomics and proteomics, scientists can begin to investigate how signaling systems evolved. Abstract »   Full Text »   PDF »   Evolution Series II »  
Evolution
(R)evolution of Complex Regulatory Systems
Rune Linding (22 June 2010)
Sci. Signal. 3 (127), eg4. [DOI: 10.1126/scisignal.3127eg4]
Understanding the implications of the changes in signaling systems requires analysis in both cellular and evolutionary time scales. Abstract »   Full Text »   PDF »   Evolution Series I »  

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ResearchPeer-reviewed original research published in Science Signaling

Developmental Biology
The Drosophila Female Germline Stem Cell Lineage Acts to Spatially Restrict DPP Function Within the Niche
Ming Liu, Tit Meng Lim, and Yu Cai (27 July 2010)
Sci. Signal. 3 (132), ra57. [DOI: 10.1126/scisignal.2000740]
Drosophila ovarian stem cells communicate with somatic cells to define the size of the stem cell niche. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Computational Biology
Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics
Kazuhiro A. Fujita, Yu Toyoshima, Shinsuke Uda, Yu-ichi Ozaki, Hiroyuki Kubota, and Shinya Kuroda (27 July 2010)
Sci. Signal. 3 (132), ra56. [DOI: 10.1126/scisignal.2000810]
The Akt pathway can serve as a signal decoupler, converting a weak receptor signal into a strong effector signal. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books

Immunology
Inhibiting the Inhibitor of the Inhibitor: Blocking PKC-{theta} to Enhance Regulatory T Cell Function
Kole T. Roybal and Christoph Wulfing (27 July 2010)
Sci. Signal. 3 (132), pe24. [DOI: 10.1126/scisignal.3132pe24]
PKC-{theta} functions differently in regulatory T cells, which may be linked to its exclusion from immune synapses. Abstract »   Full Text »   PDF »  
Evolution
The Promise of Evolutionary Systems Biology: Lessons from Bacterial Chemotaxis
Orkun S. Soyer (29 June 2010)
Sci. Signal. 3 (128), pe23. [DOI: 10.1126/scisignal.3128pe23]
Genomic analysis reveals missing links in the evolution of chemotaxis systems. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research

Cell Death
The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
Peter Vandenabeele, Wim Declercq, Franky Van Herreweghe, and Tom Vanden Berghe (30 March 2010)
Sci. Signal. 3 (115), re4. [DOI: 10.1126/scisignal.3115re4]
Programmed necrosis in response to TNF requires the activity of two serine-threonine kinases. Abstract »   Gloss »   Full Text »   PDF »  
Oxidative Stress
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
Gerasimos P. Sykiotis and Dirk Bohmann (9 March 2010)
Sci. Signal. 3 (112), re3. [DOI: 10.1126/scisignal.3112re3]
The oxidative stress response is an attractive target for treating human diseases and extending the healthy life span. Abstract »   Gloss »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research

Cell Biology
New Regulator for Energy Signaling Pathway in Plants Highlights Conservation Among Species
Anne K. Meyer, C. Friedrich H. Longin, Christian Klose, and Andreas Hermann (27 April 2010)
Sci. Signal. 3 (119), jc5. [DOI: 10.1126/scisignal.3119jc5]
The kinase CIPK links plant pathways involved in oxygen-sensing and carbohydrate metabolism. Abstract »   Full Text »   PDF »  
Immunology
Costimulatory Role of CXCR4 with Pre-TCR and Its Crosstalk with PI3K in β-Selection of Thymocytes
J. Ashik Ahamed and Periasamy Madhivadhani (27 April 2010)
Sci. Signal. 3 (119), jc4. [DOI: 10.1126/scisignal.3119jc4]
Chemokine and pre-TCR signaling cooperate in β-selection of thymocytes and promote their subsequent proliferation. Abstract »   Full Text »   PDF »  

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ProtocolsDetailed methods and troubleshooting tips for researchers

Cell Biology
Analysis of Matrix-Dependent Cell Migration with a Barrier Migration Assay
Sven Kroening and Margarete Goppelt-Struebe (15 June 2010)
Sci. Signal. 3 (126), pl1. [DOI: 10.1126/scisignal.3126pl1]
Removable plastic barriers allow quantification of cell migration without damaging either the surface proteins or the cells. Abstract »   Full Text »   PDF »  
Biochemistry
Quantitative Analysis of Protein-Lipid Interactions Using Tryptophan Fluorescence
Catherine A. Kraft, Jose Luis Garrido, Luis Leiva-Vega, and Guillermo Romero (1 December 2009)
Sci. Signal. 2 (99), pl4. [DOI: 10.1126/scisignal.299pl4]
The intrinsic fluorescence of tryptophan can be used to quantify the interaction between proteins and lipids. Abstract »   Full Text »   PDF »  

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PreviewAbstracts of upcoming articles and resources

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics

Antibodies
Response to Comment on "Increased MKK4 Abundance with Replicative Senescence Is Linked to the Joint Reduction of Multiple MicroRNAs"
Myriam Gorospe, Subramanya Srikantan, Kotb Abdelmohsen, and Bernard S. Marasa (20 July 2010)
Sci. Signal. 3 (131), lc2. [DOI: 10.1126/scisignal.3131lc2]
The antibody used to detect phosphorylated PRAK is suspect. Abstract »   Full Text »   PDF »  
Antibodies
Comment on "Increased MKK4 Abundance with Replicative Senescence Is Linked to the Joint Reduction of Multiple MicroRNAs"
Ugo Moens, Alexey Shiryaev, and Gianina Dumitriu (20 July 2010)
Sci. Signal. 3 (131), lc1. [DOI: 10.1126/scisignal.3131lc1]
The antibody used to detect phosphorylated PRAK is suspect. Abstract »   Full Text »   PDF »  

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ErrataCorrections to articles and resources

A Correction to the Research Article Titled: "c-mip Impairs Podocyte Proximal Signaling and Induces Heavy Proteinuria" by S.-y. Zhang, M. Kamal, K. Dahan, A. Pawlak, V. Ory, D. Desvaux, V. Audard, M. Candelier, F. B. Mohamed, M. Matignon, C. Christov, X. Decrouy, V. Bernard, G. Mangiapan, P. Lang, G. Guellaën, P. Ronco, D. Sahali
(25 May 2010)
Sci. Signal. 3 (123), er7. [DOI: 10.1126/scisignal.3123er7]
Full Text »   PDF »  
A Correction to the Research Article Titled: "Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation" by L. Poliseno, L. Salmena, L. Riccardi, A. Fornari, M. S. Song, R. M. Hobbs, P. Sportoletti, S. Varmeh, A. Egia, G. Fedele, L. Rameh, M. Loda, P. P. Pandolfi
(25 May 2010)
Sci. Signal. 3 (123), er6. [DOI: 10.1126/scisignal.3123er6]
Full Text »   PDF »  

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Virtual JournalA collection of cell signaling articles from participating publishers, updated daily

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