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Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research published in other journals

Cell Biology
Ironing Out the Details with Autophagy
Jason D. Berndt (15 April 2014)
Sci. Signal. 7 (321), ec99. [DOI: 10.1126/scisignal.2005363]
NCOA4 acts as a cargo adaptor protein to enable selective autophagy of ferritin, thereby regulating iron bioavailability. Abstract »  
More Myeloid Cells, STAT!
Nancy R. Gough (15 April 2014)
Sci. Signal. 7 (321), ec98. [DOI: 10.1126/scisignal.2005370]
Hematopoietic stem and progenitor cells and mesenchymal stromal cells in the bone marrow use cytokines to respond to an acute need for more myeloid cells. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues

Focus Issue: Refining the War on Cancer
Leslie K. Ferrarelli (25 March 2014)
Sci. Signal. 7 (318), eg2. [DOI: 10.1126/scisignal.2005276]
Cancer therapies must not only prevent tumor growth, but also prevent the development of drug resistance and metastases. Abstract »   Full Text »   PDF »  
Cell Biology
2013: Signaling Breakthroughs of the Year
Jason D. Berndt and Nancy R. Gough (7 January 2014)
Sci. Signal. 7 (307), eg1. [DOI: 10.1126/scisignal.2005013]
The year’s highlights include structural insights into signaling proteins, advances in understanding signaling dynamics, and advances in methods for studying cellular regulatory phenomena. Abstract »   Full Text »   PDF »  

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Research ArticlesPeer-reviewed original research providing new insights into signal transduction

Intronic miR-3151 Within BAALC Drives Leukemogenesis by Deregulating the TP53 Pathway
Ann-Kathrin Eisfeld, Sebastian Schwind, Ravi Patel, Xiaomeng Huang, Ramasamy Santhanam, Christopher J. Walker, Joseph Markowitz, Kevin W. Hoag, Tiina M. Jarvinen, Benjamin Leffel, Danilo Perrotti, William E. Carson III, Guido Marcucci, Clara D. Bloomfield, and Albert de la Chapelle (15 April 2014)
Sci. Signal. 7 (321), ra36. [DOI: 10.1126/scisignal.2004762]
Oncogenic microRNA-3151 interferes with the p53-mediated apoptosis pathway to produce more severe leukemia. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
The C-Terminal SH3 Domain Contributes to the Intramolecular Inhibition of Vav Family Proteins
María Barreira, Salvatore Fabbiano, José R. Couceiro, Eva Torreira, Jorge L. Martínez-Torrecuadrada, Guillermo Montoya, Oscar Llorca, and Xosé R. Bustelo (15 April 2014)
Sci. Signal. 7 (321), ra35. [DOI: 10.1126/scisignal.2004993]
An intramolecular double-lock system prevents spurious activation of a protein involved in lymphocyte development and cancer. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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Research ResourcesPeer-reviewed original research reporting signaling-relevant tools, techniques, and databases

mMAPS: A Flow-Proteometric Technique to Analyze Protein-Protein Interactions in Individual Signaling Complexes
Chao-Kai Chou, Heng-Huan Lee, Pei-Hsiang Tsou, Chun-Te Chen, Jung-Mao Hsu, Hirohito Yamaguchi, Ying-Nai Wang, Hong-Jen Lee, Jennifer L. Hsu, Jin-Fong Lee, Jun Kameoka, and Mien-Chie Hung (4 March 2014)
Sci. Signal. 7 (315), rs1. [DOI: 10.1126/scisignal.2004620]
Flow proteometry, fluorescence-based sorting of proteins, reveals the composition of individual protein-containing complexes. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Deep Sequencing and High-Resolution Imaging Reveal Compartment-Specific Localization of Bdnf mRNA in Hippocampal Neurons
Tristan J. Will, Georgi Tushev, Lisa Kochen, Belquis Nassim-Assir, Ivan J. Cajigas, Susanne tom Dieck, and Erin M. Schuman (17 December 2013)
Sci. Signal. 6 (306), rs16. [DOI: 10.1126/scisignal.2004520]
High-resolution analysis reveals that Bdnf transcripts are weakly but selectively localized to the cell body, not dendrites, of hippocampal neurons. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books

Host-Pathogen Interactions
ROS Open Roads to Roundworm Infection
Baomin Feng and Libo Shan (8 April 2014)
Sci. Signal. 7 (320), pe10. [DOI: 10.1126/scisignal.2005273]
Parasitic worms use plant reactive oxygen species to establish a feeding site. Abstract »   Full Text »   PDF »  
Flipping the Switch: Integrin Switching Provides Metastatic Competence
Aasakiran Madamanchi, Andries Zijlstra, and Mary M. Zutter (25 March 2014)
Sci. Signal. 7 (318), pe9. [DOI: 10.1126/scisignal.2005236]
Tumor growth and metastasis is delicately regulated by distinct β integrins. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research

Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools
David P. Doupé and Norbert Perrimon (1 April 2014)
Sci. Signal. 7 (319), re1. [DOI: 10.1126/scisignal.2005077]
Fluorescent sensors and optogenetic tools reveal temporal dynamics in cellular signaling. Abstract »   Gloss »   Full Text »   PDF »  
Developmental Biology
Hippo Gains Weight: Added Insights and Complexity to Pathway Control
Leonie Enderle and Helen McNeill (8 October 2013)
Sci. Signal. 6 (296), re7. [DOI: 10.1126/scisignal.2004208]
Multiple regulatory inputs govern Hippo pathway activity and tissue growth. Abstract »   Gloss »   Full Text »   PDF »  

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Connections Map Overviews

Plant Biology
Arabidopsis Jasmonate Signaling Pathway
Aurélie Gfeller, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm4. [DOI: 10.1126/scisignal.3109cm4]
Jasmonates regulate various aspects of physiology and development in Arabidopsis thaliana. Abstract »   Full Text »   PDF »  
Plant Biology
Jasmonate Biochemical Pathway
Aurélie Gfeller, Lucie Dubugnon, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm3. [DOI: 10.1126/scisignal.3109cm3]
Jasmonates are potent physiological and developmental regulators synthesized from fatty acid precursors. Abstract »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research

Plant Biology
How Many Salicylic Acid Receptors Does a Plant Cell Need?
Martin Kaltdorf and Muhammad Naseem (11 June 2013)
Sci. Signal. 6 (279), jc3. [DOI: 10.1126/scisignal.2003944]
Paralogous proteins NPR1, NPR3, and NPR4 are receptors for the plant immunity mediator salicylic acid. Abstract »   Full Text »   PDF »  
Computational Biology
Decoding the Language of Phosphorylation Site Dynamics
Lily A. Chylek (7 May 2013)
Sci. Signal. 6 (274), jc2. [DOI: 10.1126/scisignal.2004061]
Computational modeling sheds light on the interplay of phosphorylation and diffusion in cell signaling. Abstract »   Full Text »   PDF »   Supplementary Materials »  

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ProtocolsDetailed methods and troubleshooting tips for researchers

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Jianjiong Gao, Bülent Arman Aksoy, Ugur Dogrusoz, Gideon Dresdner, Benjamin Gross, S. Onur Sumer, Yichao Sun, Anders Jacobsen, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, and Nikolaus Schultz (2 April 2013)
Sci. Signal. 6 (269), pl1. [DOI: 10.1126/scisignal.2004088]
The cBioPortal enables integration, visualization, and analysis of multidimensional cancer genomic and clinical data. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Labeling and Identification of Direct Kinase Substrates
Scott M. Carlson and Forest M. White (5 June 2012)
Sci. Signal. 5 (227), pl3. [DOI: 10.1126/scisignal.2002568]
A strategy that uses analog-sensitive kinases enables the identification of low-abundance kinase substrates. Abstract »   Full Text »   PDF »  

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PreviewAbstracts of upcoming articles and resources

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics

Comment on "Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling"
Barbara Burtness, Shanthi Marur, Julie E. Bauman, Erica A. Golemis, Ranee Mehra, and Steven J. Cohen (11 December 2012)
Sci. Signal. 5 (254), lc5. [DOI: 10.1126/scisignal.2003734]
Targeted inhibitors used in cancer treatments may have adverse effects on immune responses. Abstract »   Full Text »   PDF »  
Cell Biology
Response to Comment on "A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation": Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool
Piero Dalle Pezze, Annika G. Sonntag, Daryl P. Shanley, and Kathrin Thedieck (10 July 2012)
Sci. Signal. 5 (232), lc4. [DOI: 10.1126/scisignal.2003224]
Dalle Pezze et al. respond to criticisms regarding the specificity of phosphorylation of Ser2481 of mTOR as a specific readout of mTORC2 activity. Abstract »   Full Text »   PDF »  

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ErrataCorrections to articles and resources

A Correction to the Research Article Titled: "The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism" by M. A. Soliman, A. M. Abdel Rahman, D. A. Lamming, K. Birsoy, J. Pawling, M. E. Frigolet, H. Lu, I. G. Fantus, A. Pasculescu,Y. Zheng, D. M. Sabatini, J. W. Dennis, T. Pawson
(4 March 2014)
Sci. Signal. 7 (315), er2. [DOI: 10.1126/scisignal.7315er2]
A correction to an author’s middle initial is made. Full Text »   PDF »  
A Correction to the Perspective Titled: "Inhibiting the Response to VEGF in Diabetes" by J. Moriya and N. Ferrara
(11 February 2014)
Sci. Signal. 7 (312), er1. [DOI: 10.1126/scisignal.7312er1]
An error in the figure of the orientation of VEGFR2 in the Golgi is corrected. Full Text »   PDF »  

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