Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Careers Booklet

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research.

Immunology
Unintentional Uptake
Stephen J. Simpson (6 May 2008)
Sci. Signal. 1 (18), ec171. [DOI: 10.1126/stke.118ec171]
A lipoprotein in human blood protects against an African parasite by binding to a parasite receptor and triggering uptake of the lipoprotein, which contains a toxic component. Abstract »  
Cell Survival
Signaling Survival Strategies
L. Bryan Ray (6 May 2008)
Sci. Signal. 1 (18), ec170. [DOI: 10.1126/stke.118ec170]
A well-studied kinase is shown to be unexpectedly phosphorylated and inhibited by mitogen-activated protein kinase, and this modification activates cell-survival pathways. Abstract »  

More Editors' Choice

Editorial Guides Articles by the editors about new features, the year's breakthroughs, or collections of related articles and resources.

Genetics
Focus Issue: Mechanisms of Gene Regulation
John F. Foley (1 April 2008)
Sci. Signal. 1 (13), eg3. [DOI: 10.1126/stke.113eg3]
Multilayered mechanisms control various aspects of gene expression. Abstract »   Full Text »   PDF »  
Cell Biology
Hear It, Watch It, Read It
Nancy R. Gough (25 March 2008)
Sci. Signal. 1 (12), eg2. [DOI: 10.1126/stke.112eg2]
Four new sections of Science Signaling bring new resources to the cell signaling community. Abstract »   Full Text »   PDF »  

More Editorial Guides

PerspectivesScientist-written opinion articles about recently published research, methods, books, or meetings.

Neuroscience
Synaptic Patterning by Morphogen Signaling
W. Ryan Williamson and P. Robin Hiesinger (6 May 2008)
Sci. Signal. 1 (18), pe20. [DOI: 10.1126/stke.118pe20]
The morphogen Activin acts as a permissive and local motility restriction signal around individual photoreceptor terminals. Abstract »   Full Text »   PDF »  
Neuroscience
VGF, a New Player in Antidepressant Action?
Jessica E. Malberg and Lisa M. Monteggia (6 May 2008)
Sci. Signal. 1 (18), pe19. [DOI: 10.1126/stke.118pe19]
The neuropeptide VGF appears to play a role in the antidepressant effects of exercise, the neurotrophic factor BDNF, and the neurotransmitter serotonin. Abstract »   Full Text »   PDF »  

More Perspectives

ReviewsPeer-reviewed articles summarizing developments in cell signaling research.

Cell Biology
Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?
Martin Lackmann and Andrew W. Boyd (15 April 2008)
Sci. Signal. 1 (15), re2. [DOI: 10.1126/stke.115re2]
Eph receptors and their ephrin ligands coordinate cell-positioning programs during development and oncogenesis. Abstract »   Gloss »   Full Text »   PDF »  
Neuroscience
Calpain in the CNS: From Synaptic Function to Neurotoxicity
Jing Liu, Ming Cheng Liu, and Kevin K. W. Wang (8 April 2008)
Sci. Signal. 1 (14), re1. [DOI: 10.1126/stke.114re1]
Physiological activation of calpains may play a role in memory, whereas pathological activation leads to cell death. Abstract »   Gloss »   Full Text »   PDF »   Animations »  

More Reviews

Journal ClubStudent-authored commentary highlighting current signal transduction research.

Neurogenesis
GABA Effects on Neurogenesis: An Arsenal of Regulation
Ti-Fei Yuan (15 April 2008)
Sci. Signal. 1 (15), jc1. [DOI: 10.1126/stke.115jc1]
GABA regulates neurogenesis in various circumstances. Abstract »   Full Text »   PDF »  
Lipid Signaling
Ceramide: From Embryos to Tumors
Iaroslav A. Savtchouk, Floyd J. Mattie, and Anne A. Ollis (10 July 2007)
Sci. STKE 2007 (394), jc1. [DOI: 10.1126/stke.3942007jc1]
A better understanding of the role of ceramides in apoptosis may lead to new antineoplastic therapies. Abstract »   Full Text »   PDF »  

More Journal Club

ProtocolsDetailed methods and troubleshooting tips for researchers.

Biochemistry
Identification of Redox-Active Cell-Surface Proteins by Mechanism-Based Kinetic Trapping
Ulla Schwertassek, Lars Weingarten, and Tobias P. Dick (18 December 2007)
Sci. STKE 2007 (417), pl8. [DOI: 10.1126/stke.4172007pl8]
This procedure allows the assessment of the oxidoreductase reactivity of cell-surface proteins within their native environment. Abstract »   Full Text »   PDF »  
Microscopy
Image Correlation Spectroscopy
Anja Nohe and Nils O. Petersen (18 December 2007)
Sci. STKE 2007 (417), pl7. [DOI: 10.1126/stke.4172007pl7]
The family of Image Correlation Spectroscopy techniques can be used to measure the aggregation, clustering, and dynamics of proteins in the plasma membrane. Abstract »   Full Text »   PDF »  

More Protocols

PreviewAbstracts of upcoming articles and resources.

Is Zinc a Neuromodulator?
Alan R. Kay and Katalin Toth
Preview published online May 6, 2008, 10.1126/stke.119re3
   Abstract »
TCR Triggering by the Peptide-MHC Complex: Valency, Affinity, and Dynamics
Rajat Varma
Preview published online May 6, 2008, 10.1126/stke.119pe21
   Abstract »

More Previews

LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics.

Response to "Shaky Ground for Lysosome-Dependent Membrane Repair"
Norma W. Andrews (4 October 2005)
Sci. STKE 2005 (304), lc2. [DOI: 10.1126/stke.3042005lc2]
Abstract »   Full Text »   PDF »  
Shaky Ground for Lysosome-Dependent Membrane Repair
Richard A. Steinhardt (4 October 2005)
Sci. STKE 2005 (304), lc1. [DOI: 10.1126/stke.3042005lc1]
Abstract »   Full Text »   PDF »  

More Letters

ErrataCorrections to articles and resources.

A Correction to the Perspective Titled "Human ITPK1: A Reversible Inositol Phosphate Kinase/Phosphatase That Links Receptor-Dependent Phospholipase C to Ca2+-Activated Chloride Channels" by A. Saiardi and S. Cockcroft
(19 February 2008)
Sci. Signal. 1 (7), er1. [DOI: 10.1126/stke.17er1]
Full Text »   PDF »  
A Correction to the Perspective Titled "Meeting Report: Zinc Signals 2007—Expanding Roles of the Free Zinc Ion in Biology" by C. Frederickson et al.
(20 November 2007)
Sci. STKE 2007 (413), er5. [DOI: 10.1126/stke.4132007er5]
Full Text »   PDF »  

More Errata

Virtual JournalA collection of cell signaling articles from participating publishers, updated daily.

Search and browse the articles in the Virtual Journal »

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products