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Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research in other journals.

Plant Biology
Flower Functionalization
Laura Zahn (30 June 2009)
Sci. Signal. 2 (77), ec222. [DOI: 10.1126/scisignal.277ec222]
An auxin gradient is involved in cell fate specification of the female sex cells in flowering plants. Abstract »  
Neuroscience
BDNF and Drug Dependence
Peter Stern (30 June 2009)
Sci. Signal. 2 (77), ec221. [DOI: 10.1126/scisignal.277ec221]
A growth factor involved in neuronal plasticity alters neurons in a specific area of the brain after chronic exposure to opioid drugs. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues.

Funding
Challenging Times
Michael B. Yaffe (30 June 2009)
Sci. Signal. 2 (77), eg8. [DOI: 10.1126/scisignal.277eg8]
The deluge of NIH "challenge grants" promises to strain the reviewer pool. Abstract »   Full Text »   PDF »  
Systems Biology
"Omic" Risk Assessment
Michael B. Major and Randall T. Moon (26 May 2009)
Sci. Signal. 2 (72), eg7. [DOI: 10.1126/scisignal.272eg7]
Integration of multiple data sets is the key to hit validation. Abstract »   Full Text »   PDF »  

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ResearchPeer-reviewed original research published in Science Signaling.

Cell Biology
PKC{varepsilon} Regulation of an {alpha}5 Integrin–ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells
Saara Tuomi, Anja Mai, Jonna Nevo, Jukka O. Laine, Vesa Vilkki, Tiina J. Ohman, Carl G. Gahmberg, Peter J. Parker, and Johanna Ivaska (30 June 2009)
Sci. Signal. 2 (77), ra32. [DOI: 10.1126/scisignal.2000135]
Phosphorylated ZO-1 relocalizes from tight junctions to lamellae to associate with {alpha}5 integrin and control migration. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Systems Biology
Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor–PI3K Axis
Birgit Schoeberl, Emily A. Pace, Jonathan B. Fitzgerald, Brian D. Harms, Lihui Xu, Lin Nie, Bryan Linggi, Ashish Kalra, Violette Paragas, Raghida Bukhalid, Viara Grantcharova, Neeraj Kohli, Kip A. West, Magdalena Leszczyniecka, Michael J. Feldhaus, Arthur J. Kudla, and Ulrik B. Nielsen (30 June 2009)
Sci. Signal. 2 (77), ra31. [DOI: 10.1126/scisignal.2000352]
Computational modeling of the ErbB signaling network affirms ErbB3 as a therapeutic target. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books.

Inflammation
AIMing 2 Detect Foreign DNA
Arthur M. Krieg (30 June 2009)
Sci. Signal. 2 (77), pe39. [DOI: 10.1126/scisignal.277pe39]
AIM2 is a receptor for cytoplasmic double-stranded DNA and induces the formation of an IL-1β–secreting inflammasome. Abstract »   Full Text »   PDF »  
Immunology
Activation of T Cells: Releasing the Brakes by Proteolytic Elimination of Cbl-b
M. Lienhard Schmitz (23 June 2009)
Sci. Signal. 2 (76), pe38. [DOI: 10.1126/scisignal.276pe38]
Degradation of the ubiquitin E3 ligase Cbl-b in response to T cell costimulation depends on PKC-{theta}. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research.

Structural Biology
The Vitamin D Sterol–Vitamin D Receptor Ensemble Model Offers Unique Insights into Both Genomic and Rapid-Response Signaling
Mathew T. Mizwicki and Anthony W. Norman (16 June 2009)
Sci. Signal. 2 (75), re4. [DOI: 10.1126/scisignal.275re4]
Different Vitamin D conformations binding to different pockets of a flexibile receptor could elicit distinct responses. Abstract »   Gloss »   Full Text »   PDF »   Supplementary Materials »  
Physiology
CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Roy L. Silverstein and Maria Febbraio (26 May 2009)
Sci. Signal. 2 (72), re3. [DOI: 10.1126/scisignal.272re3]
Signaling by CD36 is ligand and cell specific and is implicated in multiple human diseases. Abstract »   Gloss »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research.

Immunology
Drosophila Toll Pathway: The New Model
Yashwanth Ashok (6 January 2009)
Sci. Signal. 2 (52), jc1. [DOI: 10.1126/scisignal.252jc1]
New data has led to reevaluation of the proteolytic cascades that activate Toll in flies. Abstract »   Full Text »   PDF »  
Hypoxia
The HIF-1{alpha}–C/EBP{alpha} Axis
Harish P. Janardhan (28 October 2008)
Sci. Signal. 1 (43), jc2. [DOI: 10.1126/scisignal.143jc2]
Interactions between HIF-1{alpha} and C/EBP{alpha} may mediate reciprocal functional effects. Abstract »   Full Text »   PDF »  

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ProtocolsDetailed methods and troubleshooting tips for researchers.

Cell Biology
Using a Microfluidic Device for High-Content Analysis of Cell Signaling
Raymond Cheong, Chiaochun Joanne Wang, and Andre Levchenko (16 June 2009)
Sci. Signal. 2 (75), pl2. [DOI: 10.1126/scisignal.275pl2]
This method for analyzing individual cells reveals differences in responses masked by averaging across the population. Abstract »   Full Text »   PDF »  
Phosphorylation Events
Genome to Kinome: Species-Specific Peptide Arrays for Kinome Analysis
Shakiba Jalal, Ryan Arsenault, Andrew A. Potter, Lorne A. Babiuk, Philip J. Griebel, and Scott Napper (20 January 2009)
Sci. Signal. 2 (54), pl1. [DOI: 10.1126/scisignal.254pl1]
Marrying bioinformatics and phosphorylation assays enables the empirical analysis of kinomes of multiple species. Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PreviewAbstracts of upcoming articles and resources.

Caspase-8 for Outer Harmony
Gabriel Sollberger and Hans-Dietmar Beer
Preview published online June 30, 2009, 10.1126/scisignal.278pe40
   Abstract »

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics.

Response to "Shaky Ground for Lysosome-Dependent Membrane Repair"
Norma W. Andrews (4 October 2005)
Sci. STKE 2005 (304), lc2. [DOI: 10.1126/stke.3042005lc2]
Abstract »   Full Text »   PDF »  
Shaky Ground for Lysosome-Dependent Membrane Repair
Richard A. Steinhardt (4 October 2005)
Sci. STKE 2005 (304), lc1. [DOI: 10.1126/stke.3042005lc1]
Abstract »   Full Text »   PDF »  

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ErrataCorrections to articles and resources.

A Correction to the Research Article Titled: "EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma" by Q.-W. Fan, C. Cheng, Z. A. Knight, D. Haas-Kogan, D. Stokoe, C. D. James, F. McCormick, K. M. Shokat, and W. A. Weiss
(3 March 2009)
Sci. Signal. 2 (60), er4. [DOI: 10.1126/scisignal.260er4]
Full Text »   PDF »  
A Correction to the Research Article Titled "Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic" by A. Krejcí, F. Bernard, B. Housden, S. Collins, S. J. Bray
(17 February 2009)
Sci. Signal. 2 (58), er3. [DOI: 10.1126/scisignal.258er3]
Full Text »   PDF »  

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Virtual JournalA collection of cell signaling articles from participating publishers, updated daily.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882