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Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research published in other journals

Neuroscience
Natural Resistance
Laura Zahn (7 February 2012)
Sci. Signal. 5 (210), ec46. [DOI: 10.1126/scisignal.2002924]
Resistance to avermectin, an antinematode drug, is conferred by a deletion in a glutamate-gated chloride channel. Abstract »  
Development
Separated in Time and Space
Annalisa M. VanHook (7 February 2012)
Sci. Signal. 5 (210), ec45. [DOI: 10.1126/scisignal.2002925]
Sequential interactions of Notch and Wnt signaling are required for segregation of mesoderm and endoderm in the sea urchin embryo. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues

Wnt Signaling
Focus Issue: Wnt and β-Catenin Signaling in Development and Disease
Nancy R. Gough (10 January 2012)
Sci. Signal. 5 (206), eg2. [DOI: 10.1126/scisignal.2002806]
Research reveals new functions for Wnt in cancer, tooth development, and neuronal pathfinding. Abstract »   Full Text »   PDF »  
Cell Biology
2011: Signaling Breakthroughs of the Year
Elizabeth M. Adler (3 January 2012)
Sci. Signal. 5 (205), eg1. [DOI: 10.1126/scisignal.2002787]
Signaling breakthroughs in 2011 involved structural analyses of signaling proteins, technological advances in imaging, and insights into the mechanisms controlling gene expression, immune function, and the cellular response to stress. Abstract »   Full Text »   PDF »  

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Research ArticlesPeer-reviewed original research providing new insights into signal transduction

Host-Pathogen Interactions
PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE2-Mediated Inhibition of Phagocytosis of Fungi
C. Henrique Serezani, Steve Kane, Alexandra I. Medeiros, Ashley M. Cornett, Sang-Hoon Kim, Mariana Morato Marques, Sang-Pyo Lee, Casey Lewis, Emilie Bourdonnay, Megan N. Ballinger, Eric S. White, and Marc Peters-Golden (7 February 2012)
Sci. Signal. 5 (210), ra12. [DOI: 10.1126/scisignal.2002448]
By promoting actin depolymerization, the protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Cell Biology
Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7
Kathryn M. Taylor, Stephen Hiscox, Robert I. Nicholson, Christer Hogstrand, and Peter Kille (7 February 2012)
Sci. Signal. 5 (210), ra11. [DOI: 10.1126/scisignal.2002585]
Phosphorylation of the zinc channel ZIP7 releases zinc from the endoplasmic reticulum and promotes signals associated with proliferation and migration. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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Research ResourcesPeer-reviewed original research reporting signaling-relevant tools, techniques, and databases

Protein Interactions
SH3 Domain–Based Phototrapping in Living Cells Reveals Rho Family GAP Signaling Complexes
Hirokazu Okada, Akiyoshi Uezu, Frank M. Mason, Erik J. Soderblom, M. Arthur Moseley III, and Scott H. Soderling (29 November 2011)
Sci. Signal. 4 (201), rs13. [DOI: 10.1126/scisignal.2002189]
Domain-based proteomics analysis identifies binding partners and potential functions for a family of GTPase-activating proteins that regulate the cytoskeleton. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Phosphoproteomics
Systematic Phosphorylation Analysis of Human Mitotic Protein Complexes
Björn Hegemann, James R. A. Hutchins, Otto Hudecz, Maria Novatchkova, Jonathan Rameseder, Martina M. Sykora, Sihan Liu, Michael Mazanek, Péter Lénárt, Jean-Karim Hériché, Ina Poser, Norbert Kraut, Anthony A. Hyman, Michael B. Yaffe, Karl Mechtler, and Jan-Michael Peters (8 November 2011)
Sci. Signal. 4 (198), rs12. [DOI: 10.1126/scisignal.2001993]
Analysis of the phosphorylation of mitotic protein complexes suggests that specific members of the complexes relay regulatory signals to these molecular machines. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books

Cell Biology
An "Inordinate Fondness for Transporters" Explained?
David J. Eide (7 February 2012)
Sci. Signal. 5 (210), pe5. [DOI: 10.1126/scisignal.2002837]
The presence of low- and high-affinity transporters enables cells to adequately prepare for nutrient fluctuations. Abstract »   Full Text »   PDF »  
Neuroscience
Depletion of Extracellular Ca2+ Prompts Astroglia to Moderate Synaptic Network Activity
Dmitri A. Rusakov (24 January 2012)
Sci. Signal. 5 (208), pe4. [DOI: 10.1126/scisignal.2002799]
Reduced extracellular calcium stimulates astrocytes to release adenosine triphosphate, which activates inhibitory neurons and may limit excitability. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research

Cell Biology
The Emerging Role of Linear Ubiquitination in Cell Signaling
Christoph H. Emmerich, Anna C. Schmukle, and Henning Walczak (20 December 2011)
Sci. Signal. 4 (204), re5. [DOI: 10.1126/scisignal.2002187]
Linear ubiquitin chains transmit signals that are induced by diverse stimuli and regulate cell activation and death. Abstract »   Gloss »   Full Text »   PDF »  
Plant Biology
A Brand New START: Abscisic Acid Perception and Transduction in the Guard Cell
Archana Joshi-Saha, Christiane Valon, and Jeffrey Leung (29 November 2011)
Sci. Signal. 4 (201), re4. [DOI: 10.1126/scisignal.2002164]
Understanding how plants respond to the hormone abscisic acid provides targets for designing crops resilient to drought. Abstract »   Gloss »   Full Text »   PDF »  

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Connections Map Overviews

Plant Biology
Arabidopsis Jasmonate Signaling Pathway
Aurélie Gfeller, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm4. [DOI: 10.1126/scisignal.3109cm4]
Jasmonates regulate various aspects of physiology and development in Arabidopsis thaliana. Abstract »   Full Text »   PDF »  
Plant Biology
Jasmonate Biochemical Pathway
Aurélie Gfeller, Lucie Dubugnon, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm3. [DOI: 10.1126/scisignal.3109cm3]
Jasmonates are potent physiological and developmental regulators synthesized from fatty acid precursors. Abstract »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research

Neuroscience
α-Synuclein Promotes Neuroprotection Through NF-{kappa}B–Mediated Transcriptional Regulation of Protein Kinase C{delta}
Reina Aoki and Yun Rose Li (18 October 2011)
Sci. Signal. 4 (195), jc6. [DOI: 10.1126/scisignal.2002425]
α-Synuclein may protect dopaminergic neurons from apoptosis by reducing the abundance of a kinase involved in cell death. Abstract »   Full Text »   PDF »  
Cancer Biology
MicroRNAs Add an Additional Layer to the Complexity of Cell Signaling
Jason I. Herschkowitz and Xiaoyong Fu (2 August 2011)
Sci. Signal. 4 (184), jc5. [DOI: 10.1126/scisignal.2002182]
Down-regulation of microRNAs associated with EGF signaling may contribute to tumor progression. Abstract »   Full Text »   PDF »  

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ProtocolsDetailed methods and troubleshooting tips for researchers

Cell Biology
A Dual Array-Based Approach to Assess the Abundance and Posttranslational Modification State of Signaling Proteins
Katrin Luckert, Taranjit S. Gujral, Marina Chan, Thomas O. Joos, Peter K. Sorger, Gavin MacBeath, and Oliver Pötz (10 January 2012)
Sci. Signal. 5 (206), pl1. [DOI: 10.1126/scisignal.2002372]
Combining two strategies enables simultaneous quantification of multiple signaling proteins. Abstract »   Full Text »   PDF »  
Biochemistry
A Method to Separate Nuclear, Cytosolic, and Membrane-Associated Signaling Molecules in Cultured Cells
Xiaoyong Liu and François Fagotto (13 December 2011)
Sci. Signal. 4 (203), pl2. [DOI: 10.1126/scisignal.2002373]
A semipermeabilization step and a specific Percoll gradient composition enable effective cellular fractionation. Abstract »   Full Text »   PDF »  

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PreviewAbstracts of upcoming articles and resources

Measurement of cAMP in an Undergraduate Teaching Laboratory, Using ALPHAscreen Technology
Joseph D. Bartho, Kien Ly, and Debbie L. Hay
Preview published online February 7, 2012, 10.1126/scisignal.2002656
   Abstract »

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics

Theoretical Biology
Response to Comment on "‘Load-Induced Modulation of Signal Transduction Networks’: Reconciling Ultrasensitivity with Bifunctionality?"
Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, and Domitilla Del Vecchio (3 January 2012)
Sci. Signal. 5 (205), lc2. [DOI: 10.1126/scisignal.2002716]
Complex biochemical and regulatory properties of a bifunctional enzyme mean that its activity cannot be modeled as a simple bifunctional system with distinct and reciprocally regulated states. Abstract »   Full Text »   PDF »  
Theoretical Biology
Comment on "Load-Induced Modulation of Signal Transduction Networks": Reconciling Ultrasensitivity with Bifunctionality?
Ronny Straube (3 January 2012)
Sci. Signal. 5 (205), lc1. [DOI: 10.1126/scisignal.2002699]
Mathematical modeling of a bifunctional enzyme system fails to reproduce the experimentally observed ultrasensitivity of the system. Abstract »   Full Text »   PDF »   Supplementary Materials »  

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ErrataCorrections to articles and resources

A Correction to the Research Article Titled: "Time-Dependent Quantitative Multicomponent Control of the G1-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress" by M. À. Adrover, Z. Zi, A. Duch, J. Schaber, A. González-Novo, J. Jimenez, M. Nadal-Ribelles, J. Clotet, E. Klipp, F. Posas
(1 November 2011)
Sci. Signal. 4 (197), er5. [DOI: 10.1126/scisignal.4197er5]
Errors in the labels of panels C and D of Fig. 7 and incorrect text callouts to Figs. 7E and 7F are corrected. Full Text »   PDF »  
A Correction to the Review Titled: "ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity" by J. Colicelli
(30 August 2011)
Sci. Signal. 4 (188), er4. [DOI: 10.1126/scisignal.4188er4]
The erroneous second and third pages of the four-page Fig. 4 are corrected. Full Text »   PDF »  

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Virtual JournalA collection of cell signaling articles from participating publishers, updated daily

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