Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research published in other journals

Microbiology
A Gatekeeper of Viral Entry
Ernesto Andrianantoandro (22 May 2012)
Sci. Signal. 5 (225), ec147. [DOI: 10.1126/scisignal.2003246]
The receptor EphrinA2 promotes herpesvirus entry into endothelial cells. Abstract »  
Angiogenesis
Syndecan Teams Up with Notch
Ernesto Andrianantoandro (22 May 2012)
Sci. Signal. 5 (225), ec146. [DOI: 10.1126/scisignal.2003245]
Syndecan-2 enhancement of Notch signaling in smooth muscle cells may play a role in angiogenesis. Abstract »  

More Editors' Choice

Back to Top >

Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues

Structural Biology
Focus Issue: Series on Structural Biology
Wei Wong (8 May 2012)
Sci. Signal. 5 (223), eg6. [DOI: 10.1126/scisignal.2003165]
Research and commentary highlight the use of structural analysis to understand signaling molecules and events. Abstract »   Full Text »   PDF »  
Computational Biology
Focus Issue: Adding Math to the Signaling Toolkit
Wei Wong and John F. Foley (17 April 2012)
Sci. Signal. 5 (220), eg5. [DOI: 10.1126/scisignal.2003112]
Computational approaches can reveal how cells interpret, process, and respond to signals. Abstract »   Full Text »   PDF »  

More Editorial Guides

Back to Top >

Research ArticlesPeer-reviewed original research providing new insights into signal transduction

Immunology
Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
Makoto Inoue, Kristi L. Williams, Timothy Oliver, Peter Vandenabeele, Jayant V. Rajan, Edward A. Miao, and Mari L. Shinohara (22 May 2012)
Sci. Signal. 5 (225), ra38. [DOI: 10.1126/scisignal.2002767]
Characterization of an animal model may explain why not all patients with multiple sclerosis respond to interferon-β. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Biochemistry
An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt
Kui Lin, Jie Lin, Wen-I Wu, Joshua Ballard, Brian B. Lee, Susan L. Gloor, Guy P. A. Vigers, Tony H. Morales, Lori S. Friedman, Nicholas Skelton, and Barbara J. Brandhuber (8 May 2012)
Sci. Signal. 5 (223), ra37. [DOI: 10.1126/scisignal.2002618]
ATP and ATP-competitive inhibitors prevent dephosphorylation of the kinase Akt. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

More Research Articles

Back to Top >

Research ResourcesPeer-reviewed original research reporting signaling-relevant tools, techniques, and databases

Cancer
MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma
Kris C. Wood, David J. Konieczkowski, Cory M. Johannessen, Jesse S. Boehm, Pablo Tamayo, Olga B. Botvinnik, Jill P. Mesirov, William C. Hahn, David E. Root, Levi A. Garraway, and David M. Sabatini (15 May 2012)
Sci. Signal. 5 (224), rs4. [DOI: 10.1126/scisignal.2002612]
Miniaturized functional genomics uncovers potentially useful combination therapies and drug targets for melanoma. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Cell Biology
Studying the Dynamics of SLP-76, Nck, and Vav1 Multimolecular Complex Formation in Live Human Cells with Triple-Color FRET
Maor H. Pauker, Nirit Hassan, Elad Noy, Barak Reicher, and Mira Barda-Saad (24 April 2012)
Sci. Signal. 5 (221), rs3. [DOI: 10.1126/scisignal.2002423]
The formation of a multiprotein complex in response to T cell activation is monitored in live cells. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

More Research Resources

Back to Top >

PerspectivesScientist-written opinion articles about recently published research, methods, or books

Structural Biology
Revisiting Channel Allostery: A Coherent Mechanism in IP3 and Ryanodine Receptors
Kozo Hamada and Katsuhiko Mikoshiba (22 May 2012)
Sci. Signal. 5 (225), pe24. [DOI: 10.1126/scisignal.2003148]
Structural analyses suggest a similar gating mechanism in the IP3 and ryanodine receptors. Abstract »   Full Text »   PDF »  
Structural Biology
Structure of the First Sphingosine 1-Phosphate Receptor
Abby L. Parrill, Santiago Lima, and Sarah Spiegel (22 May 2012)
Sci. Signal. 5 (225), pe23. [DOI: 10.1126/scisignal.2003160]
The lipid sphingosine 1-phosphate may laterally diffuse through the membrane to bind a receptor. Abstract »   Full Text »   PDF »  

More Perspectives

Back to Top >

ReviewsPeer-reviewed articles summarizing developments in cell signaling research

Computational Biology
Computational Approaches for Analyzing Information Flow in Biological Networks
Boris Kholodenko, Michael B. Yaffe, and Walter Kolch (17 April 2012)
Sci. Signal. 5 (220), re1. [DOI: 10.1126/scisignal.2002961]
Signaling network construction and analysis provide insights into biology and medicine. Abstract »   Gloss »   Full Text »   PDF »  
Cell Biology
The Emerging Role of Linear Ubiquitination in Cell Signaling
Christoph H. Emmerich, Anna C. Schmukle, and Henning Walczak (20 December 2011)
Sci. Signal. 4 (204), re5. [DOI: 10.1126/scisignal.2002187]
Linear ubiquitin chains transmit signals that are induced by diverse stimuli and regulate cell activation and death. Abstract »   Gloss »   Full Text »   PDF »  

More Reviews

Back to Top >

Connections Map Overviews

Plant Biology
Arabidopsis Jasmonate Signaling Pathway
Aurélie Gfeller, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm4. [DOI: 10.1126/scisignal.3109cm4]
Jasmonates regulate various aspects of physiology and development in Arabidopsis thaliana. Abstract »   Full Text »   PDF »  
Plant Biology
Jasmonate Biochemical Pathway
Aurélie Gfeller, Lucie Dubugnon, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm3. [DOI: 10.1126/scisignal.3109cm3]
Jasmonates are potent physiological and developmental regulators synthesized from fatty acid precursors. Abstract »   Full Text »   PDF »  

More Connections Map Overviews

Back to Top >

Journal ClubStudent-authored commentary highlighting current signal transduction research

Neuroscience
The Role of EHD Proteins at the Neuronal Synapse
Maria S. Ioannou and Andrea L. Marat (24 April 2012)
Sci. Signal. 5 (221), jc1. [DOI: 10.1126/scisignal.2002989]
The Eps15 homology domain promotes synaptic vesicle formation by limiting the extent of dynamin helix formation. Abstract »   Full Text »   PDF »  
Neuroscience
α-Synuclein Promotes Neuroprotection Through NF-{kappa}B–Mediated Transcriptional Regulation of Protein Kinase C{delta}
Reina Aoki and Yun Rose Li (18 October 2011)
Sci. Signal. 4 (195), jc6. [DOI: 10.1126/scisignal.2002425]
α-Synuclein may protect dopaminergic neurons from apoptosis by reducing the abundance of a kinase involved in cell death. Abstract »   Full Text »   PDF »  

More Journal Club

Back to Top >

ProtocolsDetailed methods and troubleshooting tips for researchers

A Systematic Approach for Analysis of Peptide Array Kinome Data
Yue Li, Ryan J. Arsenault, Brett Trost, Jillian Slind, Philip J. Griebel, Scott Napper, and Anthony Kusalik (17 April 2012)
Sci. Signal. 5 (220), pl2. [DOI: 10.1126/scisignal.2002429]
A new method of analysis of kinome data takes account of the differences between peptide arrays and DNA microarrays. Abstract »   Full Text »   PDF »   Supplementary Materials »  
Cell Biology
A Dual Array-Based Approach to Assess the Abundance and Posttranslational Modification State of Signaling Proteins
Katrin Luckert, Taranjit S. Gujral, Marina Chan, Thomas O. Joos, Peter K. Sorger, Gavin MacBeath, and Oliver Pötz (10 January 2012)
Sci. Signal. 5 (206), pl1. [DOI: 10.1126/scisignal.2002372]
Combining two strategies enables simultaneous quantification of multiple signaling proteins. Abstract »   Full Text »   PDF »  

More Protocols

Back to Top >

PreviewAbstracts of upcoming articles and resources

Structural Insights into the Assembly of Large Oligomeric Signalosomes in the Toll-Like Receptor–Interleukin-1 Receptor Superfamily
Ryan Ferrao, Jixi Li, Elisa Bergamin, and Hao Wu
Preview published online May 22, 2012, 10.1126/scisignal.2003124
   Abstract »
Signal Activation and Inactivation by the Gα Helical Domain: A Long-Neglected Partner in G Protein Signaling
Henrik G. Dohlman and Janice C. Jones
Preview published online May 22, 2012, 10.1126/scisignal.2003013
   Abstract »

More Previews

Back to Top >

LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics

Theoretical Biology
Response to Comment on "‘Load-Induced Modulation of Signal Transduction Networks’: Reconciling Ultrasensitivity with Bifunctionality?"
Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, and Domitilla Del Vecchio (3 January 2012)
Sci. Signal. 5 (205), lc2. [DOI: 10.1126/scisignal.2002716]
Complex biochemical and regulatory properties of a bifunctional enzyme mean that its activity cannot be modeled as a simple bifunctional system with distinct and reciprocally regulated states. Abstract »   Full Text »   PDF »  
Theoretical Biology
Comment on "Load-Induced Modulation of Signal Transduction Networks": Reconciling Ultrasensitivity with Bifunctionality?
Ronny Straube (3 January 2012)
Sci. Signal. 5 (205), lc1. [DOI: 10.1126/scisignal.2002699]
Mathematical modeling of a bifunctional enzyme system fails to reproduce the experimentally observed ultrasensitivity of the system. Abstract »   Full Text »   PDF »   Supplementary Materials »  

More Letters

Back to Top >

ErrataCorrections to articles and resources

A Correction to the Perspective Titled: "The Structure of the TLR5-Flagellin Complex: A New Mode of Pathogen Detection, Conserved Receptor Dimerization for Signaling" by J. Lu and P. D. Sun
(8 May 2012)
Sci. Signal. 5 (223), er3. [DOI: 10.1126/scisignal.5223er3]
Full Text »   PDF »  
A Correction to the Research Article Titled: "Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization" by Y. Wang, H. He, N. Srivastava, S. Vikarunnessa, Y.-b. Chen, J. Jiang, C. W. Cowan, X. Zhang
(13 March 2012)
Sci. Signal. 5 (215), er2. [DOI: 10.1126/scisignal.5215er2]
The authors correct a sequence range in the Materials and Methods section. Full Text »   PDF »  

More Errata

Back to Top >

Virtual JournalA collection of cell signaling articles from participating publishers, updated daily

Search and browse the articles in the Virtual Journal »
Back to Top >

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882