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Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research in other journals.

Biochemistry
Periplasmic Redox Regulation
Stella M. Hurtley (24 November 2009)
Sci. Signal. 2 (98), ec381. [DOI: 10.1126/scisignal.298ec381]
A thioredoxin-like enzyme controls the oxidation state of the bacterial periplasm. Abstract »  
Neuroscience
Dysbindin Function in Synaptic Homeostasis
Stella M. Hurtley (24 November 2009)
Sci. Signal. 2 (98), ec380. [DOI: 10.1126/scisignal.298ec380]
The dysbindin protein is required for the modulation of presynaptic neurotransmitter release in Drosophila. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues.

Cell Biology
Focus Issue: Coping with Cellular Stress
Wei Wong (10 November 2009)
Sci. Signal. 2 (96), eg14. [DOI: 10.1126/scisignal.296eg14]
Cells use diverse signaling pathways to sense and respond to stress. Abstract »   Full Text »   PDF »  
Neuroscience
Focus Issue: Addressing Complicated Questions in Neuroscience
Nancy R. Gough (20 October 2009)
Sci. Signal. 2 (93), eg13. [DOI: 10.1126/scisignal.293eg13]
Multiple approaches are needed to understand brain biology and pathology. Abstract »   Full Text »   PDF »  

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ResearchPeer-reviewed original research published in Science Signaling.

Calcium Signaling
Ca2+ Puffs Originate from Preestablished Stable Clusters of Inositol Trisphosphate Receptors
Ian F. Smith, Steven M. Wiltgen, Jianwei Shuai, and Ian Parker (24 November 2009)
Sci. Signal. 2 (98), ra77. [DOI: 10.1126/scisignal.2000466]
Localized calcium signals called Ca2+ puffs arise at preestablished clusters of IP3Rs. Editors' Summary »   Abstract »   Full Text »   PDF »  
Evolution
Eukaryotic Protein Domains as Functional Units of Cellular Evolution
Jing Jin, Xueying Xie, Chen Chen, Jin Gyoon Park, Chris Stark, D. Andrew James, Marina Olhovsky, Rune Linding, Yongyi Mao, and Tony Pawson (24 November 2009)
Sci. Signal. 2 (98), ra76. [DOI: 10.1126/scisignal.2000546]
Clustering proteins into groups on the basis of their domain compositions provides insight into protein evolution. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books.

Immunology
Maintaining Diplomatic Relations Between Mammals and Beneficial Microbial Communities
David A. Hill and David Artis (24 November 2009)
Sci. Signal. 2 (98), pe77. [DOI: 10.1126/scisignal.298pe77]
The adaptive immune system compensates if innate mechanisms fail to contain microbes in the mammalian intestine. Abstract »   Full Text »   PDF »  
Posttranslational Modification
Acetylation Goes Global: The Emergence of Acetylation Biology
Kristi L. Norris, Joo-Yong Lee, and Tso-Pang Yao (17 November 2009)
Sci. Signal. 2 (97), pe76. [DOI: 10.1126/scisignal.297pe76]
Proteomic analysis shows protein acetylation to be more prevalent than previously appreciated. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research.

Neuroscience
G Protein–Coupled Receptors, Cholinergic Dysfunction, and Aβ Toxicity in Alzheimer’s Disease
Amantha Thathiah and Bart De Strooper (20 October 2009)
Sci. Signal. 2 (93), re8. [DOI: 10.1126/scisignal.293re8]
β-amyloid may induce neurodegeneration by affecting G protein–coupled receptor signaling. Abstract »   Gloss »   Full Text »   PDF »  
Biochemistry
Transduction of Redox Signaling by Electrophile-Protein Reactions
Tanja K. Rudolph and Bruce A. Freeman (29 September 2009)
Sci. Signal. 2 (90), re7. [DOI: 10.1126/scisignal.290re7]
Attachment of electrophilic products of redox reactions to proteins links cell function to changes in metabolic and inflammatory status. Abstract »   Gloss »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research.

Immunology
Drosophila Toll Pathway: The New Model
Yashwanth Ashok (6 January 2009)
Sci. Signal. 2 (52), jc1. [DOI: 10.1126/scisignal.252jc1]
New data has led to reevaluation of the proteolytic cascades that activate Toll in flies. Abstract »   Full Text »   PDF »  
Hypoxia
The HIF-1{alpha}–C/EBP{alpha} Axis
Harish P. Janardhan (28 October 2008)
Sci. Signal. 1 (43), jc2. [DOI: 10.1126/scisignal.143jc2]
Interactions between HIF-1{alpha} and C/EBP{alpha} may mediate reciprocal functional effects. Abstract »   Full Text »   PDF »  

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ProtocolsDetailed methods and troubleshooting tips for researchers.

Cell Biology
Analysis of Signaling Events by Dynamic Phosphoflow Cytometry
Guylene Firaguay and Jacques A. Nunes (1 September 2009)
Sci. Signal. 2 (86), pl3. [DOI: 10.1126/scisignal.286pl3]
State-specific antibodies combined with flow cytometry detect the activity of signaling pathways. Abstract »   Full Text »   PDF »  
Cell Biology
Using a Microfluidic Device for High-Content Analysis of Cell Signaling
Raymond Cheong, Chiaochun Joanne Wang, and Andre Levchenko (16 June 2009)
Sci. Signal. 2 (75), pl2. [DOI: 10.1126/scisignal.275pl2]
This method for analyzing individual cells reveals differences in responses masked by averaging across the population. Abstract »   Full Text »   PDF »  

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PreviewAbstracts of upcoming articles and resources.

Quantitative Analysis of Protein-Lipid Interactions Using Tryptophan Fluorescence
Catherine A. Kraft, Jose Luis Garrido, Luis Leiva-Vega, and Guillermo Romero
Preview published online November 24, 2009, 10.1126/scisignal.299pl4
   Abstract »

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics.

Response to "Shaky Ground for Lysosome-Dependent Membrane Repair"
Norma W. Andrews (4 October 2005)
Sci. STKE 2005 (304), lc2. [DOI: 10.1126/stke.3042005lc2]
Abstract »   Full Text »   PDF »  
Shaky Ground for Lysosome-Dependent Membrane Repair
Richard A. Steinhardt (4 October 2005)
Sci. STKE 2005 (304), lc1. [DOI: 10.1126/stke.3042005lc1]
Abstract »   Full Text »   PDF »  

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ErrataCorrections to articles and resources.

A Correction to the Perspective Titled: "Emerging Miniaturized Proteomic Technologies to Study Cell Signaling in Clinical Samples" by Taranjit S. Gujral and Gavin MacBeath
(27 October 2009)
Sci. Signal. 2 (94), er9. [DOI: 10.1126/scisignal.294er9]
Full Text »   PDF »  
A Correction to the Research Article Titled: " Complexity in Transcription Control at the Activation Domain–Mediator Interface" by M. A. Balamotis, M. A. Pennella, J. L. Stevens, B. Wasylyk, A. S. Belmont, A. J. Berk
(22 September 2009)
Sci. Signal. 2 (89), er8. [DOI: 10.1126/scisignal.289er8]
Full Text »   PDF »  

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Virtual JournalA collection of cell signaling articles from participating publishers, updated daily.

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