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Literature
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Editors' Choice Editorial summaries of current research.
- Immunology
Unintentional Uptake
- Stephen J. Simpson (6 May 2008)
Sci. Signal. 1 (18), ec171. [DOI: 10.1126/stke.118ec171]
A lipoprotein in human blood protects against an African parasite by binding to a parasite receptor and triggering uptake of the lipoprotein, which contains a toxic component.
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- Cell Survival
Signaling Survival Strategies
- L. Bryan Ray (6 May 2008)
Sci. Signal. 1 (18), ec170. [DOI: 10.1126/stke.118ec170]
A well-studied kinase is shown to be unexpectedly phosphorylated and inhibited by mitogen-activated protein kinase, and this modification activates cell-survival pathways.
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Editorial Guides Articles by the editors about new features, the year's breakthroughs, or collections of related articles and resources.
- Genetics
Focus Issue: Mechanisms of Gene Regulation
- John F. Foley (1 April 2008)
Sci. Signal. 1 (13), eg3. [DOI: 10.1126/stke.113eg3]
Multilayered mechanisms control various aspects of gene expression.
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- Cell Biology
Hear It, Watch It, Read It
- Nancy R. Gough (25 March 2008)
Sci. Signal. 1 (12), eg2. [DOI: 10.1126/stke.112eg2]
Four new sections of Science Signaling bring new resources to the cell signaling community.
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PerspectivesScientist-written opinion articles about recently published research, methods, books, or meetings.
- Neuroscience
Synaptic Patterning by Morphogen Signaling
- W. Ryan Williamson and P. Robin Hiesinger (6 May 2008)
Sci. Signal. 1 (18), pe20. [DOI: 10.1126/stke.118pe20]
The morphogen Activin acts as a permissive and local motility restriction signal around individual photoreceptor terminals.
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- Neuroscience
VGF, a New Player in Antidepressant Action?
- Jessica E. Malberg and Lisa M. Monteggia (6 May 2008)
Sci. Signal. 1 (18), pe19. [DOI: 10.1126/stke.118pe19]
The neuropeptide VGF appears to play a role in the antidepressant effects of exercise, the neurotrophic factor BDNF, and the neurotransmitter serotonin.
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ReviewsPeer-reviewed articles summarizing developments in cell signaling research.
- Cell Biology
Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?
- Martin Lackmann and Andrew W. Boyd (15 April 2008)
Sci. Signal. 1 (15), re2. [DOI: 10.1126/stke.115re2]
Eph receptors and their ephrin ligands coordinate cell-positioning programs during development and oncogenesis.
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- Neuroscience
Calpain in the CNS: From Synaptic Function to Neurotoxicity
- Jing Liu, Ming Cheng Liu, and Kevin K. W. Wang (8 April 2008)
Sci. Signal. 1 (14), re1. [DOI: 10.1126/stke.114re1]
Physiological activation of calpains may play a role in memory, whereas pathological activation leads to cell death.
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Journal ClubStudent-authored commentary highlighting current signal transduction research.
- Neurogenesis
GABA Effects on Neurogenesis: An Arsenal of Regulation
- Ti-Fei Yuan (15 April 2008)
Sci. Signal. 1 (15), jc1. [DOI: 10.1126/stke.115jc1]
GABA regulates neurogenesis in various circumstances.
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- Lipid Signaling
Ceramide: From Embryos to Tumors
- Iaroslav A. Savtchouk, Floyd J. Mattie, and Anne A. Ollis (10 July 2007)
Sci. STKE 2007 (394), jc1. [DOI: 10.1126/stke.3942007jc1]
A better understanding of the role of ceramides in apoptosis may lead to new antineoplastic therapies.
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ProtocolsDetailed methods and troubleshooting tips for researchers.
- Biochemistry
Identification of Redox-Active Cell-Surface Proteins by Mechanism-Based Kinetic Trapping
- Ulla Schwertassek, Lars Weingarten, and Tobias P. Dick (18 December 2007)
Sci. STKE 2007 (417), pl8. [DOI: 10.1126/stke.4172007pl8]
This procedure allows the assessment of the oxidoreductase reactivity of cell-surface proteins within their native environment.
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- Microscopy
Image Correlation Spectroscopy
- Anja Nohe and Nils O. Petersen (18 December 2007)
Sci. STKE 2007 (417), pl7. [DOI: 10.1126/stke.4172007pl7]
The family of Image Correlation Spectroscopy techniques can be used to measure the aggregation, clustering, and dynamics of proteins in the plasma membrane.
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PreviewAbstracts of upcoming articles and resources.
- Is Zinc a Neuromodulator?
- Alan R. Kay and Katalin Toth
Preview published online May 6, 2008, 10.1126/stke.119re3
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- TCR Triggering by the Peptide-MHC Complex: Valency, Affinity, and Dynamics
- Rajat Varma
Preview published online May 6, 2008, 10.1126/stke.119pe21
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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics.
- Response to "Shaky Ground for Lysosome-Dependent Membrane Repair"
- Norma W. Andrews (4 October 2005)
Sci. STKE 2005 (304), lc2. [DOI: 10.1126/stke.3042005lc2]
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- Shaky Ground for Lysosome-Dependent Membrane Repair
- Richard A. Steinhardt (4 October 2005)
Sci. STKE 2005 (304), lc1. [DOI: 10.1126/stke.3042005lc1]
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ErrataCorrections to articles and resources.
- A Correction to the Perspective Titled "Human ITPK1: A Reversible Inositol Phosphate Kinase/Phosphatase That Links Receptor-Dependent Phospholipase C to Ca2+-Activated Chloride Channels" by A. Saiardi and S. Cockcroft
- (19 February 2008)
Sci. Signal. 1 (7), er1. [DOI: 10.1126/stke.17er1]
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- A Correction to the Perspective Titled "Meeting Report: Zinc Signals 2007—Expanding Roles of the Free Zinc Ion in Biology" by C. Frederickson et al.
- (20 November 2007)
Sci. STKE 2007 (413), er5. [DOI: 10.1126/stke.4132007er5]
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