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Literature

Use the links below to quickly browse to sample articles in Literature:

Editors' Choice Editorial summaries of current research published in other journals

Channels
Potassium Permeation
Valda Vinson (31 January 2012)
Sci. Signal. 5 (209), ec39. [DOI: 10.1126/scisignal.2002894]
Structural features provide a basis for understanding gating and ion conduction of these channels. Abstract »  
DNA Damage
Damage Switch
Wei Wong (31 January 2012)
Sci. Signal. 5 (209), ec38. [DOI: 10.1126/scisignal.2002896]
ATM-mediated phosphorylation of Mdm2 after genotoxic stress causes Mdm2 to promote, rather than inhibit, p53 activity. Abstract »  

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Editorial Guides Scientist-written editorials and staff-written summaries of new features, the year's breakthroughs, or focus issues

Wnt Signaling
Focus Issue: Wnt and β-Catenin Signaling in Development and Disease
Nancy R. Gough (10 January 2012)
Sci. Signal. 5 (206), eg2. [DOI: 10.1126/scisignal.2002806]
Research reveals new functions for Wnt in cancer, tooth development, and neuronal pathfinding. Abstract »   Full Text »   PDF »  
Cell Biology
2011: Signaling Breakthroughs of the Year
Elizabeth M. Adler (3 January 2012)
Sci. Signal. 5 (205), eg1. [DOI: 10.1126/scisignal.2002787]
Signaling breakthroughs in 2011 involved structural analyses of signaling proteins, technological advances in imaging, and insights into the mechanisms controlling gene expression, immune function, and the cellular response to stress. Abstract »   Full Text »   PDF »  

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Research ArticlesPeer-reviewed original research providing new insights into signal transduction

Cell Biology
PAS Kinase Promotes Cell Survival and Growth Through Activation of Rho1
Caleb M. Cardon, Thomas Beck, Michael N. Hall, and Jared Rutter (31 January 2012)
Sci. Signal. 5 (209), ra9. [DOI: 10.1126/scisignal.2002435]
The Rho1-activating complex formed by yPASK-phosphorylated Ugp1 enables yeast to overcome loss of Tor2 function. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Cell Biology
Myosin I Links PIP3 Signaling to Remodeling of the Actin Cytoskeleton in Chemotaxis
Chun-Lin Chen, Yu Wang, Hiromi Sesaki, and Miho Iijima (31 January 2012)
Sci. Signal. 5 (209), ra10. [DOI: 10.1126/scisignal.2002446]
A subset of myosin motor proteins binds the membrane phospholipid PIP3 to link membrane and cytoskeletal dynamics. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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Research ResourcesPeer-reviewed original research reporting signaling-relevant tools, techniques, and databases

Protein Interactions
SH3 Domain–Based Phototrapping in Living Cells Reveals Rho Family GAP Signaling Complexes
Hirokazu Okada, Akiyoshi Uezu, Frank M. Mason, Erik J. Soderblom, M. Arthur Moseley III, and Scott H. Soderling (29 November 2011)
Sci. Signal. 4 (201), rs13. [DOI: 10.1126/scisignal.2002189]
Domain-based proteomics analysis identifies binding partners and potential functions for a family of GTPase-activating proteins that regulate the cytoskeleton. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Phosphoproteomics
Systematic Phosphorylation Analysis of Human Mitotic Protein Complexes
Björn Hegemann, James R. A. Hutchins, Otto Hudecz, Maria Novatchkova, Jonathan Rameseder, Martina M. Sykora, Sihan Liu, Michael Mazanek, Péter Lénárt, Jean-Karim Hériché, Ina Poser, Norbert Kraut, Anthony A. Hyman, Michael B. Yaffe, Karl Mechtler, and Jan-Michael Peters (8 November 2011)
Sci. Signal. 4 (198), rs12. [DOI: 10.1126/scisignal.2001993]
Analysis of the phosphorylation of mitotic protein complexes suggests that specific members of the complexes relay regulatory signals to these molecular machines. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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PerspectivesScientist-written opinion articles about recently published research, methods, or books

Neuroscience
Depletion of Extracellular Ca2+ Prompts Astroglia to Moderate Synaptic Network Activity
Dmitri A. Rusakov (24 January 2012)
Sci. Signal. 5 (208), pe4. [DOI: 10.1126/scisignal.2002799]
Reduced extracellular calcium stimulates astrocytes to release adenosine triphosphate, which activates inhibitory neurons and may limit excitability. Abstract »   Full Text »   PDF »  
Microbiology
A Pseudokinase Debut at the Mycobacterial Cell Wall
Digby F. Warner and Valerie Mizrahi (24 January 2012)
Sci. Signal. 5 (208), pe3. [DOI: 10.1126/scisignal.2002785]
A serine-threonine kinase targets a pseudokinase to control the synthesis of the cell wall of the bacterium that causes tuberculosis. Abstract »   Full Text »   PDF »  

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ReviewsPeer-reviewed articles summarizing developments in cell signaling research

Cell Biology
The Emerging Role of Linear Ubiquitination in Cell Signaling
Christoph H. Emmerich, Anna C. Schmukle, and Henning Walczak (20 December 2011)
Sci. Signal. 4 (204), re5. [DOI: 10.1126/scisignal.2002187]
Linear ubiquitin chains transmit signals that are induced by diverse stimuli and regulate cell activation and death. Abstract »   Gloss »   Full Text »   PDF »  
Plant Biology
A Brand New START: Abscisic Acid Perception and Transduction in the Guard Cell
Archana Joshi-Saha, Christiane Valon, and Jeffrey Leung (29 November 2011)
Sci. Signal. 4 (201), re4. [DOI: 10.1126/scisignal.2002164]
Understanding how plants respond to the hormone abscisic acid provides targets for designing crops resilient to drought. Abstract »   Gloss »   Full Text »   PDF »  

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Connections Map Overviews

Plant Biology
Arabidopsis Jasmonate Signaling Pathway
Aurélie Gfeller, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm4. [DOI: 10.1126/scisignal.3109cm4]
Jasmonates regulate various aspects of physiology and development in Arabidopsis thaliana. Abstract »   Full Text »   PDF »  
Plant Biology
Jasmonate Biochemical Pathway
Aurélie Gfeller, Lucie Dubugnon, Robin Liechti, and Edward E. Farmer (16 February 2010)
Sci. Signal. 3 (109), cm3. [DOI: 10.1126/scisignal.3109cm3]
Jasmonates are potent physiological and developmental regulators synthesized from fatty acid precursors. Abstract »   Full Text »   PDF »  

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Journal ClubStudent-authored commentary highlighting current signal transduction research

Neuroscience
α-Synuclein Promotes Neuroprotection Through NF-{kappa}B–Mediated Transcriptional Regulation of Protein Kinase C{delta}
Reina Aoki and Yun Rose Li (18 October 2011)
Sci. Signal. 4 (195), jc6. [DOI: 10.1126/scisignal.2002425]
α-Synuclein may protect dopaminergic neurons from apoptosis by reducing the abundance of a kinase involved in cell death. Abstract »   Full Text »   PDF »  
Cancer Biology
MicroRNAs Add an Additional Layer to the Complexity of Cell Signaling
Jason I. Herschkowitz and Xiaoyong Fu (2 August 2011)
Sci. Signal. 4 (184), jc5. [DOI: 10.1126/scisignal.2002182]
Down-regulation of microRNAs associated with EGF signaling may contribute to tumor progression. Abstract »   Full Text »   PDF »  

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ProtocolsDetailed methods and troubleshooting tips for researchers

Cell Biology
A Dual Array-Based Approach to Assess the Abundance and Posttranslational Modification State of Signaling Proteins
Katrin Luckert, Taranjit S. Gujral, Marina Chan, Thomas O. Joos, Peter K. Sorger, Gavin MacBeath, and Oliver Pötz (10 January 2012)
Sci. Signal. 5 (206), pl1. [DOI: 10.1126/scisignal.2002372]
Combining two strategies enables simultaneous quantification of multiple signaling proteins. Abstract »   Full Text »   PDF »  
Biochemistry
A Method to Separate Nuclear, Cytosolic, and Membrane-Associated Signaling Molecules in Cultured Cells
Xiaoyong Liu and François Fagotto (13 December 2011)
Sci. Signal. 4 (203), pl2. [DOI: 10.1126/scisignal.2002373]
A semipermeabilization step and a specific Percoll gradient composition enable effective cellular fractionation. Abstract »   Full Text »   PDF »  

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PreviewAbstracts of upcoming articles and resources

An "Inordinate Fondness for Transporters" Explained?
David J. Eide
Preview published online January 31, 2012, 10.1126/scisignal.2002837
   Abstract »

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LettersLetters to the editor about specific Science Signaling articles or other cell signaling topics

Theoretical Biology
Response to Comment on "‘Load-Induced Modulation of Signal Transduction Networks’: Reconciling Ultrasensitivity with Bifunctionality?"
Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, and Domitilla Del Vecchio (3 January 2012)
Sci. Signal. 5 (205), lc2. [DOI: 10.1126/scisignal.2002716]
Complex biochemical and regulatory properties of a bifunctional enzyme mean that its activity cannot be modeled as a simple bifunctional system with distinct and reciprocally regulated states. Abstract »   Full Text »   PDF »  
Theoretical Biology
Comment on "Load-Induced Modulation of Signal Transduction Networks": Reconciling Ultrasensitivity with Bifunctionality?
Ronny Straube (3 January 2012)
Sci. Signal. 5 (205), lc1. [DOI: 10.1126/scisignal.2002699]
Mathematical modeling of a bifunctional enzyme system fails to reproduce the experimentally observed ultrasensitivity of the system. Abstract »   Full Text »   PDF »   Supplementary Materials »  

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ErrataCorrections to articles and resources

A Correction to the Research Article Titled: "Time-Dependent Quantitative Multicomponent Control of the G1-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress" by M. À. Adrover, Z. Zi, A. Duch, J. Schaber, A. González-Novo, J. Jimenez, M. Nadal-Ribelles, J. Clotet, E. Klipp, F. Posas
(1 November 2011)
Sci. Signal. 4 (197), er5. [DOI: 10.1126/scisignal.4197er5]
Errors in the labels of panels C and D of Fig. 7 and incorrect text callouts to Figs. 7E and 7F are corrected. Full Text »   PDF »  
A Correction to the Review Titled: "ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity" by J. Colicelli
(30 August 2011)
Sci. Signal. 4 (188), er4. [DOI: 10.1126/scisignal.4188er4]
The erroneous second and third pages of the four-page Fig. 4 are corrected. Full Text »   PDF »  

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Virtual JournalA collection of cell signaling articles from participating publishers, updated daily

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