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Theoretical Biology
Response to Comment on "‘Load-Induced Modulation of Signal Transduction Networks’: Reconciling Ultrasensitivity with Bifunctionality?"
Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa, and Domitilla Del Vecchio (3 January 2012)
Sci. Signal. 5 (205), lc2. [DOI: 10.1126/scisignal.2002716]
Complex biochemical and regulatory properties of a bifunctional enzyme mean that its activity cannot be modeled as a simple bifunctional system with distinct and reciprocally regulated states. Abstract »   Full Text »   PDF »  
Theoretical Biology
Comment on "Load-Induced Modulation of Signal Transduction Networks": Reconciling Ultrasensitivity with Bifunctionality?
Ronny Straube (3 January 2012)
Sci. Signal. 5 (205), lc1. [DOI: 10.1126/scisignal.2002699]
Mathematical modeling of a bifunctional enzyme system fails to reproduce the experimentally observed ultrasensitivity of the system. Abstract »   Full Text »   PDF »   Supplementary Materials »  

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