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Research Articles Archive

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Physiology
MNK2 Inhibits eIF4G Activation Through a Pathway Involving Serine-Arginine–Rich Protein Kinase in Skeletal Muscle
Shou-Ih Hu, Mark Katz, Sherry Chin, Xiaoqing Qi, Joseph Cruz, Chikwendu Ibebunjo, Shanchuan Zhao, Amy Chen, and David J. Glass (14 February 2012)
Sci. Signal. 5 (211), ra14. [DOI: 10.1126/scisignal.2002466]
In muscle, the kinase-dependent and -independent functions of MNK2 inhibit the protein translation protein eIF4G under conditions that promote atrophy. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Immunology
Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist
William S. Bowen, Laurie A. Minns, David A. Johnson, Thomas C. Mitchell, Melinda M. Hutton, and Jay T. Evans (14 February 2012)
Sci. Signal. 5 (211), ra13. [DOI: 10.1126/scisignal.2001963]
A single change in a synthetic lipid A mimetic may reduce the toxicity of this vaccine adjuvant. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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