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Host-Pathogen Interactions
Trypanosoma cruzi Targets Akt in Host Cells as an Intracellular Antiapoptotic Strategy
Marina V. Chuenkova and Mercio PereiraPerrin (17 November 2009)
Sci. Signal. 2 (97), ra74. [DOI: 10.1126/scisignal.2000374]
A surface protein of the intracellular parasite Trypanosoma cruzi acts both intracellularly and extracellularly to keep infected cells alive. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Cancer
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, and Jing Chen (17 November 2009)
Sci. Signal. 2 (97), ra73. [DOI: 10.1126/scisignal.2000431]
Tyrosine phosphorylation of pyruvate kinase M2 gives tumor cells a metabolic advantage. Editors' Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

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