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STKE publishes Focus Issues and individual articles in conjunction with Science Special Issues. Below you will find a list of STKE articles and resources that complement particular issues or articles in Science.

[2006] [2005] [2004] [2003] [2002] [2001]

Science Special Issue: Cancer Treatment Gets Personal (26 May 2006)

Editorial Guide

  • E. M. Adler, Focus Issue -- Focus Issue: Turning the Corner in Cancer Therapy? Sci. STKE 2006, eg8 (2006). [Summary] [Full Text]

Perspectives

  • K. L. Harms, X. Chen, p19ras brings a new twist to the regulation of p73 by Mdm2. Sci. STKE 2006, pe24 (2006). [Abstract] [Full Text]

  • J. A. Garcia, HIFing the brakes: Therapeutic opportunities for treatment of human malignancies. Sci. STKE 2006, pe25 (2006). [Abstract] [Full Text]

Science Special Issue: Topics in Virology (12 May 2006)

Editorial Guide

  • E. M. Adler, Focus Issue -- Focus Issue: Viruses—Miniature Machiavellis of the Signaling World? Sci. STKE 2006, eg7 (2006). [Summary] [Full Text]

Reviews

  • S. D. Hayward, J. Liu, M. Fujimuro, Notch and Wnt Signaling: Mimicry and Manipulation by Gamma Herpesviruses. Sci. STKE 2006, re2 (2006). [Gloss][Abstract] [Full Text]
  • S. Münter, M. Way, F. Frischknecht, Signaling During Pathogen Infection. Sci. STKE 2006, re5 (2006). [Gloss][Abstract] [Full Text][Movie]

Perspective

  • M. Barry, Klaus Früh, Viral Modulators of Cullin RING Ubiquitin Ligases: Culling the Host Defense. Sci. STKE 2006, pe21 (2006). [Abstract] [Full Text]

Science Special Issue: Tools for Biochemistry (14 April 2006)

Editorial Guide

  • E. M. Adler, Focus Issue -- Peering into the Proteome. Sci. STKE 2006, eg5 (2006). [Summary] [Full Text]

Review

  • S. S. Vogel, C. Thaler, S. V. Koushik, Fanciful FRET. Sci. STKE 2006, re2 (2006). [Gloss][Abstract] [Full Text]

Protocol

  • P. M. England, Rapid Photoinactivation of Native AMPA Receptors on Live Cells Using ANQX. Sci. STKE 2006, pl1 (2006). [Abstract] [Full Text]

Science Special Issue: Detection Techniques (17 March 2006)

Editorial Guide

  • N. R. Gough, Focus Issue: Measurement on a Small Scale. Sci. STKE 2006, eg4 (2006). [Summary] [Full Text]

Perspectives

  • L. Cognet, L. Groc, B. Lounis, D. Choquet, Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses. Sci. STKE 2006, pe13 (2006). [Summary] [Full Text]

  • I. Lynch, K. A. Dawson, S. Linse, Detecting Cryptic Epitopes Created by Nanoparticles. Sci. STKE 2006, pe14 (2006). [Summary] [Full Text]

Science Special Issue: Plant Volatiles (10 February 2006)

Editorial Guide

  • N. R. Gough, Focus Issue -- Plant Communication. Sci. STKE 2006, eg3 (2006). [Summary] [Full Text]

Perspective

  • R. G. Vogt, How Sensitive Is a Nose? Sci. STKE 2006, pe8 (2006). [Summary] [Full Text]

Teaching Resource

  • M. Laskowski, Model of the TIR1 Pathway for Auxin-Mediated Gene Expression. Sci. STKE 2006, tr1 (2006). [Summary] [Full Text]

Connection Maps

  • A. Gfeller, R. Liechti, E. E. Farmer, Arabidopsis Jasmonate Signaling Pathway. Sci. STKE 2006, tr1 (2006). [Summary] [Full Text]

  • R. Liechti, A. Gfeller, E. E. Farmer, Jasmonate Signaling Pathway. Sci. STKE 2006, tr2 (2006). [Summary] [Full Text]

  • R. Liechti and E. E. Farmer, Jasmonate Biochemical Pathway. Sci. STKE 2006, tr3 (2006). [Summary] [Full Text]

Science Special Issue: Crossing Membranes (7 December 2005)

Editorial Guide

  • N. R. Gough, Focus Issue -- Signaling Across Membranes Sci. STKE 2005, eg11 (2005). [Summary] [Full Text]

Perspective

  • C. Hisatsune and K. Mikoshiba, Novel Compartment Implicated in Calcium Signaling -- Is It an "Induced Coupling Domain"? Sci. STKE 2005, pe53 (2005). [Summary] [Full Text]

  • A. Joliot, Transduction Peptides Within Naturally Occurring Proteins. Sci. STKE 2005, pe54 (2005). [Summary] [Full Text]

  • B. Önfelt, M. A. Purbhoo, S. Nedvetzki, S. Sowinski, D. M. Davis, Long-Distance Calls Between Cells Connected by Tunneling Nanotubules. Sci. STKE 2005, pe55 (2005). [Summary] [Full Text]

Teaching Resource

  • D. P. Felsenfeld, Regulation of Complexes by Cytoskeletal Elements -- Integrins Serve as Force Transducers Linking Mechanical Stimuli and Biochemical Signals. Sci. STKE 2005, tr27 (2005). [Summary] [Full Text]

Science Special Issue: Brain Development (4 November 2005)

Editorial Guide

  • E. M. Adler, N. R. Gough, Focus Issue -- Memories of Signals Past--Plastic Changes in Nervous System Function Sci. STKE 2005, eg10 (2005). [Summary] [Full Text]

Perspective

  • B. E. Alger, Endocannabinoid Identification in the Brain -- Studies of Breakdown Lead to Breakthrough, and There May Be NO Hope. Sci. STKE 2005, pe51 (2005). [Summary] [Full Text]

  • L. A. Noon and A. C. Lloyd, Hijacking the ERK Signaling Pathway -- Mycobacterium leprae Shuns MEK to Drive the Proliferation of Infected Schwann Cells. Sci. STKE 2005, pe52 (2005). [Summary] [Full Text]

Review

  • D. Ron and R. Jurd, The "Ups and Downs" of Signaling Cascades in Addiction. Sci. STKE 2005, re14 (2005). [Summary] [Full Text]

Teaching Resource

  • R. D. Blitzer, Long-Term Potentiation -- Mechanisms of Induction and Maintenance. Sci. STKE 2005, tr26 (2005). [Summary] [Full Text]

Science Special Issue: Cell Signaling (7 October 2005)

Editorial Guide

  • L. B. Ray, N. R. Gough, E. M. Adler, Focus Issue -- Signaling: From Stem Cells to Dead Cells Sci. STKE 2005, eg9 (2005). [Summary] [Full Text]

Viewpoints

  • D. Spierings, G. McStay, M. Saleh, C. Bender, J. Chipuk, U. Maurer, D. R. Green, Connected to Death: The (Unexpurgated) Mitochondrial Pathway of ApoptosisScience 309, 66-67 (2005). [Summary] [Full Text]
  • L. Mishra, R. Derynck, B. Mishra, Transforming Growth Factor-â Signaling in Stem Cells and Cancer Science 309, 68-71 (2005). [Summary] [Full Text]

  • S. M. Assmann, G Proteins Go Green: A Plant G Protein Signaling FAQ Sheet. Science 309, 71-73 (2005). [Summary] [Full Text]

Science Special Issue: Mapping RNA Form and Function (2 September 2005)

Editorial Guide

  • N. R. Gough, E. M. Adler, Focus Issue -- RNA, A Multifunctional Molecule Sci. STKE 2005, eg8 (2005). [Summary] [Full Text]

Perspective

  • H. Vaucheret, MicroRNA-Dependent Trans-Acting siRNA Production Sci. STKE 2005, pe43 (2005). [Summary] [Full Text]

Teaching Resources

  • D. C. Weinstein, A Journal-Club Discussion of Regulation by microRNA Sci. STKE 2005, tr24 (2005). [Summary] [Full Text]

  • K. S. Kosik and A. M. Krichevsky, A Model for Local Regulation of Translation Near Active Synapses. Sci. STKE 2005, tr25 (2005). [Summary] [Full Text]

Science Special Issue: Drug Discovery (29 July 2005)

Editorial Guide

  • N. R. Gough, Focus Issue -- Drug Discovery. Sci. STKE 2005, eg7 (2005). [Summary] [Full Text]

Perspectives

  • S. Bartz and A. L. Jackson, How Will RNAi Facilitate Drug Development? Sci. STKE 2005, pe39 (2005). [Summary] [Full Text]

  • E. E. Schadt, A. Sachs, S. Friend, Embracing Complexity, Inching Closer to Reality Sci. STKE 2005, pe40 (2005). [Summary] [Full Text]

Review

  • B. Nilius, T. Voets, J. Peters, TRP Channels in Disease. Sci. STKE 2005, re8 (2005). [Summary] [Full Text]

Science Special Issue: The Trypanosomatid Genomes (15 July 2005)

Perspective

  • B. A. Burleigh, Host Cell Signaling and Trypanosoma cruzi Invasion -- Do All Roads Lead to Lysosomes? Sci. STKE 2005, pe36 (2005). [Summary] [Full Text]

Science Special Issue: Anniversary Issue 125 Anniversary: 125 Questions--What We Don't Know (1 July 2005)

Editorial Guide

  • L. B. Ray, E. M. Adler, N. R. Gough, Focus Issue -- Signals from the Past. Sci. STKE 2005, eg6 (2005). [Summary] [Full Text]

Science Special Issue: Women's Health (10 June 2005)

Editorial Guide

  • L. B. Ray, E. M. Adler, N. R. Gough, Focus Issue -- Women's Health. Sci. STKE 2005, eg5 (2005). [Summary] [Full Text]

Perspectives

  • D. K. Biswas, S. Singh,Q. Shi, A. B. Pardee, J. D. Iglehart, Crossroads of Estrogen Receptor and NF-kB Signaling. Sci. STKE 2005, pe27 (2005). [Summary] [Full Text]

  • K. H. Kim and J. R. Bender, Rapid, Estrogen Receptor-Mediated Signaling -- Why Is the Endothelium So Special? Sci. STKE 2005, pe28 (2005). [Summary] [Full Text]

  • D. J. McCance, Rapid, Human Papillomaviruses and Cell Signaling Sci. STKE 2005, pe29 (2005). [Summary] [Full Text]

Science Special Issue: Distributed Computing (6 May 2005)

Perspectives

  • R. Hoffmann, M. Krallinger, E. Andres, J. Tamames, C. Blaschke, A. Valencia, Text Mining for Metabolic Pathways, Signaling Cascades, and Protein Networks. Sci. STKE 2005, pe21 (2005). [Summary] [Full Text]
  • E. Neumann, A Life Science Semantic Web: Are We There Yet? Sci. STKE 2005, pe22 (2005). [Summary] [Full Text]

Science Special Issue: The Gut (25 March 2005)

Editorial Guide

  • E. M. Adler, Focus Issue: Going for the Gut. Sci. STKE 2005, eg4 (2005). [Summary] [Full Text]

Perspectives

  • R. B. Emeson, M. V. Morabito, Food Fight: The NPY-Serotonin Link Between Aggression and Feeding Behavior. Sci. STKE 2005, pe12 (2005). [Summary] [Full Text]
  • F. Hollande, A. Shulkes, G. S. Baldwino, Signaling the Junctions in Gut Epithelium. Sci. STKE 2005, pe13 (2005). [Summary] [Full Text]
  • R. M. Peek Jr., Orchestration of Aberrant Epithelial Signaling by Helicobacter pylori CagA. Sci. STKE 2005, pe14 (2005). [Summary] [Full Text]
  • K. A. Sharkey, Q. J. Pittman, Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding: A Perspective on the Munchies. Sci. STKE 2005, pe15 (2005). [Summary] [Full Text]

Science Special Issue: Type 2 Diabetes (21 January 2005)

Editorial Guide

  • E. M. Adler, Focus Issue: Diabetes—Fighting Fat on Multiple Fronts. Sci. STKE 2005, eg2 (2005). [Summary] [Full Text]

Perspective

  • G. G. Holz, Diabetes Outfoxed by GLP-1? Sci. STKE 2005, pe2 (2005). [Summary] [Full Text]
  • E. Ikonen, S. Vainio, Lipid Microdomains and Insulin Resistance: Is There a Connection? Sci. STKE 2005, pe3 (2005). [Summary] [Full Text]
  • Y. Zick, Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance Sci. STKE 2005, pe4 (2005). [Summary] [Full Text]

Science Special Issue: Cell Signaling (26 November 2004)

Editorial Guide

  • N. R. Gough, E. M. Adler, L. B. Ray, Focus issue—Cell Signaling—Making New Connections. Sci. STKE 2004, eg12 (2004). [Summary] [Full Text]

Science Special Issue: Genes in Action (22 October 2004)

Editorial Guide

  • N. R. Gough, Focus issue—The dynamics of gene expression. Sci. STKE 2004, eg11 (2004). [Summary] [Full Text]

Perspective

  • A. M. Fowler, E. T. Alarid, Dynamic control of nuclear receptor transcription. Sci. STKE 2004, pe51 (2004). [Summary] [Full Text]

Review

  • J. Z. Dalgaard, S. Vengrova, Selective gene expression in multigene families from yeast to mammals. Sci. STKE 2004, re17 (2004). [Gloss] [Abstract] [Full Text]

Protocols

  • A. K. Nagaich, G. L. Hager, UV laser crosslinking: A real-time assay to study dynamic protein/DNA interactions during chromatin remodeling. Sci. STKE 2004, pl13 (2004). [Abstract] [Full Text]

Science Special Issue: Cognition & Behavior (15 October 2004)

Editorial Guide

  • E. M. Adler, N. R. Gough, Focus issue—Signals along a road to the mind? Sci. STKE 2004, eg10 (2004). [Summary] [Full Text]

Perspective

  • A. Pollack, Coactivation of D1 and D2 dopamine receptors: In marriage, a case of his, hers, and theirs. Sci. STKE 2004, pe50 (2004). [Summary] [Full Text]

Review

  • S. G. Cull-Candy, D. N. Leszkiewicz, Role of distinct NMDA receptor subtypes at central synapses. Sci. STKE 2004, re16 (2004). [Gloss] [Abstract] [Full Text]

Science Special Issue: Piecing Together Human Aging (3 September 2004)

Review

  • M. Hughes-Fulford, Signal transduction and mechanical stress. Sci. STKE 2004, re12 (2004). [Gloss] [Abstract] [Full Text]

Science Special Issue: Testing Human Limits (30 July 2004)

Perspective

  • D. J. Handelsman, Designer androgens in sport: When Too Much Is Never Enough. Sci. STKE 2004, pe41 (2004). [Summary] [Full Text]

Review

  • V. Sartorelli, M. Fulco, Molecular and cellular determinants of skeletal muscle atrophy and hypertrophy. Sci. STKE 2004, re11 (2004). [Abstract] [Full Text]

Science Special Issue: Immunotherapy (9 July 2004)

Editorial Guide

  • E. M. Adler, Focus issue—Tailoring the immune response. Sci. STKE 2004, eg9 (2004). [Summary] [Full Text]

Perspectives

  • E. G. Engleman, J. Brody, L. Soares, Using signaling pathways to overcome immune tolerance to tumors. Sci. STKE 2004, pe28 (2004). [Summary] [Full Text]
  • V. Heissmeyer, A. Rao, E3 ligases in T cell anergy—Turning immune responses into tolerance. Sci. STKE 2004, pe29 (2004). [Summary] [Full Text]
  • A. J. Olszewski, M. L. Grossbard, Empowering targeted therapy: Lessons from rituximab. Sci. STKE 2004, pe30 (2004). [Summary] [Full Text]

Science Special Issue: Drug Discovery (19 March 2004)

Editorial Guide

  • N. R. Gough, E. M. Adler, L. B. Ray, Focus issue—Targeting signaling pathways for drug discovery Sci. STKE 2004, eg5 (2004). [Summary] [Full Text]

Perspectives

  • W. G. Kaelin, Jr., Gleevec: Prototype or outlier? Sci. STKE 2004, pe12 (2004). [Summary] [Full Text]
  • M. R. Philips, Methotrexate and Ras methylation: A new trick for an old drug? Sci. STKE 2004, pe13 (2004). [Summary] [Full Text]
  • B. Shen, Accessing natural products by combinatorial biosynthesis. Sci. STKE 2004, pe14 (2004). [Summary] [Full Text]

Review

  • D. S. Charney, H. K. Manji, Life stress, genes, and depression: Multiple pathways lead to increased risk and new opportunities for intervention. Sci. STKE 2004, re5 (2004). [Abstract] [Full Text]

Science Special Issue: Evolution of Language (27 February 2004)

Editorial Guide

  • L. B. Ray, N. R. Gough, Focus issue—Evolution of language. Sci. STKE 2004, eg4 (2004). [Summary] [Full Text]

Perspectives

  • M. I. Aladjem, S. Pasa, S. Parodi, J. N. Weinstein, Y. Pommier, K. W. Kohn, Molecular interaction maps—A diagrammatic graphical language for bioregulatory networks. Sci. STKE 2004, pe8 (2004). [Summary] [Full Text][Cell Cycle eMIMs]
  • B. R. Franza, From play to laws: Language in biology. Sci. STKE 2004, pe9 (2004). [Summary] [Full Text]

Connections Maps

  • Connections Maps Database [Pathways]
  • Connections Maps Help and Description [Full Text]

Science Special Issue: Mathematics in Biology (6 February 2004)

Editorial Guide

  • L. B. Ray, E. M. Adler, N. R. Gough, L. D. Chong, Focus issue—Computational approaches in signal transduction. Sci. STKE 2004, eg3 (2004). [Summary] [Full Text]

Review

  • S. Sukharev, D. P. Corey, Mechanosensitive channels: Multiplicity of families and gating paradigms. Sci. STKE 2004, re4 (2004). [Gloss][Abstract] [Full Text]

Protocols

  • T. Kortemme, D. E. Kim, D. Baker, Computational alanine scanning of protein-protein interfaces. Sci. STKE 2004, pl2 (2004). [Abstract] [Full Text]
  • B. Kutscher, P. Devreotes, P. A. Iglesias, Local excitation, global inhibition mechanism for gradient sensing: An interactive applet. Sci. STKE 2004, pl3 (2004). [Abstract] [Full Text][Applet]
  • S. J. Vayttaden, U. S. Bhalla, Developing complex signaling models using GENESIS/Kinetikit. Sci. STKE 2004, pl4 (2004). [Abstract] [Full Text][Software and Demos]
  • R. Yasuda, E. A. Nimchinsky, V. Scheuss, T. A. Pologruto, T. G. Oertner, B. L. Sabatini, K. Svoboda, Imaging calcium concentration dynamics in small neuronal compartments. Sci. STKE 2004, pl5 (2004). [Abstract] [Full Text]

Forum

  • Open Discussion of Modeling and Computational Approaches to Cellular Signaling. [Discussion]

Science Special Issue: Brain Disease (31 October 2003)

Editorial Guide

  • E. M. Adler, N. R. Gough, Focus issue: Brain disease--Signaling on my mind. Sci. STKE 2003, eg14 (2003). [Full Text]

Perspective

  • M. E. MacDonald, Huntingtin: Alive and well and working in middle management. Sci. STKE 2003, pe48 (2003). [Summary] [Full Text]
  • H. K. Manji, I. I. Gottesman, T. D. Gould, Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Sci. STKE 2003, pe49 (2003). [Summary] [Full Text]
  • M. B. Robinson, Signaling pathways take target on neurotransmitter reporters. Sci. STKE 2003, pe50 (2003). [Summary] [Full Text]

Science Special Issue: Genomic Medicine (24 October 2003)

Editorial Guide

  • N. R. Gough, L. D. Chong, Focus issue: Genomic medicine--Opening the door to discovery. Sci. STKE 2003, eg13 (2003). [Full Text]
Perspective
  • S. E. Levy, Microarray analysis in drug discovery: An uplifting view of depression. Sci. STKE 2003, pe46 (2003). [Summary] [Full Text]
  • J. B. Opalinska, A. M. Gewirtz, Therapeutic potential of antisense nucleic acid molecules. Sci. STKE 2003, pe47 (2003). [Summary] [Full Text]

Science Special Issue: Networks in Biology (26 September 2003)

Perspective

  • Wagner, Does Selection Mold Molecular Networks? Sci. STKE 2003, pe41 (2003). [Summary] [Full Text]

Science Special Issue: The Dynamic Chromosome (8 August 2003)

Editorial Guide

  • L. D. Chong, E. M. Adler, Focus issue: To the chromosome, and beyond! Sci. STKE 2003, eg12 (2003). [Full Text]
Review
  • K. M. McBride, N. C. Reich, The ins and outs of STAT1 nuclear transport. Sci. STKE 2003, re13 (2003). [Gloss] [Abstract] [Full Text]
Perspective
  • J. R. Davie, MSK1 and MSK2 mediate mitogen- and stress-induced phosphorylation of histone H3: A controversy resolved. Sci. STKE 2003, pe33 (2003). [Summary] [Full Text]

Science Special Issue: Developmental Timing (18 July 2003)

Editorial Guide

  • L. D. Chong, E. M. Adler, N. R. Gough, Focus issue: Time passages. Sci. STKE 2003, eg11 (2003). [Full Text]
Perspectives
  • O. Acuto, T cell-dendritic cell interaction in vivo: Random encounters favor development of long-lasting ties. Sci. STKE 2003, pe28 (2003). [Summary] [Full Text]
  • B. D. Goldman, Pattern of melatonin secretion mediates transfer of photoperiod information from mother to fetus in mammals. Sci. STKE 2003, pe29 (2003). [Summary] [Full Text]
  • A. M. Michelson, Running interference for Hedgehog signaling. Sci. STKE 2003, pe30 (2003). [Summary] [Full Text]

Science Special Issue: Tree of Life (13 June 2003)

Review

  • Ben-Shlomo, S. Yu Hsu, R. Rauch, H. W. Kowalski, A. J. W. Hsueh, Signaling receptome: A genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction. Sci. STKE 2003, re9 (2003). [Gloss] [Abstract] [Full Text]
Forum
  • Genomes: A Platform for Signal Transduction Research? [Discussion]

Science Special Issue: Building Signaling Connections (6 June 2003)

Editorial Guide

  • N. R. Gough, E. M. Adler, L. B. Ray, Focus issue: Building signaling connections. Sci. STKE 2003, eg8 (2003). [Full Text]

Science Special Issue: Metals: Impacts on Health and the Environment (9 May 2003)

Editorial Guide

  • E. M. Adler, N. R. Gough, L. D. Chong, Focus issue: Metals in biology: Coin for the signaling realm? Sci. STKE 2003, eg7 (2003). [Full Text]
Perspectives
  • C. Bouton, J.-C. Drapier, Iron regulatory proteins as NO signal transducers. Sci. STKE 2003, pe17 (2003). [Summary] [Full Text]
  • C. J. Frederickson, Imaging zinc: Old and new tools. Sci. STKE 2003, pe18 (2003). [Summary] [Full Text]
  • Y. V. Li, C. J. Hough, J. M. Sarvey, Do we need zinc to think? Sci. STKE 2003, pe19 (2003). [Summary] [Full Text]

Science Special Issue: Biological Imaging (4 April 2003)

Editorial Guide

  • E. M. Adler, L. D. Chong, N. R. Gough, Focus issue: A sharp focus on cell signaling. Sci. STKE 2003, eg5 (2003). [Full Text]
Perspectives
  • D. M. Bers, Dynamic imaging in living cells: Windows into local signaling. Sci. STKE 2003, pe13 (2003). [Summary] [Full Text]
  • P. Ramm, N. Thomas, Image-based screening of signal transduction assays. Sci. STKE 2003, pe14 (2003). [Summary] [Full Text]
Protocols
  • S. C. Bunnell, V. A. Barr, C. L. Fuller, L. E. Samelson, High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates. Sci. STKE, 2003, pl8 (2003). [Abstract] [Full Text] [Movies 1 and 2]
  • I. A. Prior, R. G. Parton, J. F. Hancock, Observing cell surface signaling domains using electron microscopy. Sci. STKE 2003, pl9 (2003). [Abstract] [Full Text]

Science Special Issue: Aging (28 February 2003)

Editorial Guide

  • N. R. Gough, L. D. Chong, E. M. Adler, L. B. Ray, Focus issue: Aging--A multifaceted issue. Sci. STKE 2003, eg4 (2003). [Full Text]
Reviews
  • T. E. Golde, C. B. Eckman, Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis. Sci. STKE 2003, re4 (2003). [Gloss] [Abstract] [ Full Text]
  • H. Tran, A. Brunet, E. C. Griffith, M. E. Greenberg, The many forks in FOXO's road. Sci. STKE 2003, re5 (2003). [Gloss] [Abstract] [Full Text]

Science Special Issue: Obesity (7 February 2003)

Editorial Guide

  • L. D. Chong, E, M. Adler, L. B. Ray, Focus issue: The signaling skinny on obesity. Sci. STKE 2003, eg2 (2003). [Full Text]
Perspectives
  • K. V. Kandror, A long search for Glut4 activation. Sci. STKE 2003, pe5 (2003). [Summary] [Full Text]
  • D. L. Krebs, D. J. Hilton, A new role for SOCS in insulin action. Sci. STKE 2003, pe6 (2003). [Summary] [Full Text]
  • P. Trayhurn, Leptin--a critical body weight signal and a "master" hormone? Sci. STKE 2003, pe7 (2003). [Summary] [Full Text]
Protocol
  • A. Tengholm, M. N. Teruel, T. Meyer, Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy. Sci. STKE, 2003, pl4 (2003). [Summary] [Full Text]
Connections Map
  • M. White, Insulin signaling pathway. Sci. STKE (Connections Map as seen January 2003), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_12069. [Canonical Pathway]

Science Exploring the Human Kinome (6 December 2002)

Editorial Guide

  • L. B. Ray, N. R. Gough, Focus issue: The kinome--Techniques and methods for analysis. Sci. STKE 2002, eg13 (2002). [ Full Text]

Perspectives

  • B. D. Manning, L. C. Cantley, Hitting the target: Emerging technologies in the search for kinase substrates. Sci. STKE 2002, pe49 (2002). [Summary] [Full Text]
  • S. Pelech, H. Zhang, Plastisticity of the kinomes in monkey and rat tissues. Sci. STKE 2002, pe50 (2002). [Summary] [Full Text] [Data and Methods]

Protocol

  • S. Eyckerman, I. Lemmens, S. Lievens, J. Van der Heyden, A. Verhee, J. Vandekerckhove, J. Tavernier, Design and use of a mammalian protein-protein interaction trap (MAPPIT). Sci. STKE 2002, pl18 (2002). [Abstract] [Full Text]

Connections Maps

  • R. Lapadat, G. L. Johnson, p38 MAPK pathway. Sci. STKE (Connections Map as seen December 2002), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_10958. [Canonical Pathway]
  • R. Lapadat, G. L. Johnson, JNK MAPK pathway. Sci. STKE (Connections Map as seen December 2002), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_10827. [Canonical Pathway]
  • R. Lapadat, G. L. Johnson, ERK1/ERK2 MAPK pathway. Sci. STKE (Connections Map as seen December 2002), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_10705. [Canonical Pathway]

Science Special Issue: Polarity: From Cell to Organism (6 December 2002)

Editorial Guide

  • L. D. Chong, E. M. Adler, N. R. Gough, Focus issue: Polarity signals--from cell to organism. Sci. STKE 2002, eg12 (2002). [Full Text]

Perspectives

  • C. Gonzalez, Aurora-A in cell fate control. Sci. STKE 2002, pe48 (2002). [Summary] [Full Text]
  • K. R. Robinson, M. A. Messerli, Pulsating ion fluxes and growth at the pollen tube tip. Sci. STKE 2002 pe51 (2002). [Summary] [Full Text]
  • Q. Shen, S. Temple, Creating asymmetric cell divisions by skewing endocytosis.Sci. STKE 2002, pe52 (2002). [Summary] [Full Text]

Science Special Issue: The Dynamic Synapse (25 October 2002)

Editorial Guide

  • L. D. Chong, N. R. Gough, L. B. Ray, The dynamic synapse: Neuronal nexus for signaling. Sci. STKE 2002, eg11 (2002). [Full Text]

Review

Perspective

  • S. deSouza, E. B. Ziff, AMPA receptors do the electric slide. Sci. STKE 2002, pe45 (2002). [Summary] [Full Text]

Science Special Issue: Genome Instability (26 July 2002)

Perspective

  • S. A. Wood, Dubble or nothing? Is HAUSP deubiquitylating enzyme the final arbiter of p53 levels? Sci. STKE 2002, pe34 (2002).[Summary] [Full Text]

Science Special Issue: Reproductive Biology (21 June 2002)

Editorial Guide

  • L. D. Chong, L. B. Ray, Reproductive biology. Sci. STKE 2002, eg9 (2002). [Full Text]

Review

  • A. C. B. Cato, A. Nestl, S. Mink, Rapid actions of steroid receptors in cellular signaling pathways. Sci. STKE 2002, re9 (2002). [Gloss] [Abstract] [Full Text]

Perspective

  • L. Wang, S. Andersson, M. Warner, J.-Å. Gustafsson, Estrogen actions in the brain. Sci. STKE 2002, pe29 (2002). [ Summary] [Full Text]

Science Special Issue: Mapping Cellular Signaling (31 May 2002)

Editorial Guide

  • N. R. Gough, L. B. Ray, Mapping cellular signaling. Sci. STKE 2002, eg8 (2002). [Full Text]

Science Special Issue: RNA Silencing and Noncoding RNA (17 May 2002)

Editorial Guide

  • L. D. Chong, L. B. Ray, N. R. Gough, Coding and noncoding RNA: An expanding RNA world. Sci. STKE 2002, eg6 (2002). [Full Text]

Perspective

  • C. Schmauss, J. R. Howe, RNA editing of neurotransmitter receptors in the mammalian brain. Sci. STKE 2002, pe26 (2002). [Summary] [Full Text]

Science Special Issue: Environmental Microbiology (10 May 2002)

Editorial Guide

  • L. D. Chong, L. B. Ray, N. R. Gough, Focus issue on environmental microbiology: The microbial signaling frontier. Sci. STKE 2002, eg6 (2002). [Full Text]

Review

  • M. A. Schembri, M. Givskov, P. Klemm, An attractive surface: Gram-negative bacterial biofilms. Sci. STKE 2002, re6 (2002).[Gloss] [Abstract] [Full Text]

Perspectives

  • F. W. Dahlquist, Amplification of signaling events in bacteria. Sci. STKE 2002, pe24 (2002). [Summary] [Full Text]
  • J. B. Stock, M. N. Levit, P. M. Wolanin, Information processing in bacterial chemotaxis. Sci. STKE 2002, pe25 (2002).[Summary] [Full Text]

Science Special Issue: The Puzzle of Complex Diseases (26 April 2002)

Editorial Guide

  • L. D. Chong, The puzzle of complex disease: The signaling piece. Sci. STKE 2002, eg5 (2002). [Full Text]

Perspectives

  • H. A. Fozzard, J. W. Kyle, Do defects in ion channel glycosylation set the stage for lethal cardiac arrhythmias? Sci. STKE 2002, pe19 (2002). [Summary] [Full Text]
  • M. N. Liebman, Opening Pandora's box: Clinical data and the study of complex disease. Sci. STKE 2002, pe20 (2002). [Summary] [Full Text]
  • K. J. Tracey, Lethal weight loss: The focus shifts to signal transduction. Sci. STKE 2002, pe21 (2002). [Summary] [Full Text]

Protocol

  • Z. Dong, J. L. Cmarik, Harvesting cells under Anchorage-independent cell transformation conditions for biochemical analyses. Sci. STKE 2002, pl7 (2002). [Abstract] [Full Text]

Science Special Issue: Reflections on Self: Immunity and Beyond (12 April 2002)

Editorial Guide

  • L. D. Chong, Reflections on self--Self-serving signals. Sci. STKE 2002, eg4 (2002). [Full Text]

Review

  • G. Bismuth, L. Boumsell, Controlling the immune system through semaphorins. Sci. STKE 2002, re4 (2002). [Gloss] [Abstract] [Full Text]

Perspective

  • C. E. Rudd, M. Martín, H. Schneider, CTLA-4 negative signaling via lipid rafts: A new perspective. Sci. STKE 2002, pe18 (2002). [Summary] [Full Text]

Protocol

  • T. Zell and Marc K. Jenkins, Flow cytometric analysis of T cell receptor signal transduction. Sci. STKE 2002, pl15 (2002). [Abstract] [Full Text]

Science Special Issue: Systems Biology (1 March 2002)

Editorial Guide

  • L. Chong, STKE focus issue on systems biology: Painting the signaling picture. Sci. STKE 2002, eg2 (2002). [Full Text]

Perspectives

  • A. K. Chakraborty, How and why does the immunological synapse form? Physical chemistry meets cell biology. Sci. STKE 2002, pe10 (2002). [Summary] [Full Text]
  • L. Lok. Software for signaling networks, electronic and cellular. Sci. STKE 2002, pe11 (2002). [Summary] [Full Text]

Science Special Issue: Bodybuilding--The Bionic Human (8 February 2002)

Editorial Guide

  • L. D. Chong, STKE focus issue on the bionic human: The molecular signaling of tissue repair
    Sci. STKE 2002, eg1 (2002). [Full Text]

Review

  • Z. He, K. C. Wang, V. Koprivica, G. Ming and H.-J. Song, Knowing how to navigate: Mechanisms of semaphorin signaling in the nervous system. Sci. STKE 2002, re1 (2002). [Gloss] [Abstract] [Full Text]

Perspectives

  • F. J. Alenghat, D. E. Ingber, Mechanotransduction: All signals point to cytoskeleton, matrix, and integrins. Sci. STKE 2002, pe6 (2002). [Summary] [Full Text]
  • D. G. Stupack, D. A. Cheresh, ECM remodeling regulates angiogenesis: Endothelial integrins look for new ligands. Sci. STKE 2002, pe7 (2002). [Summary] [Full Text]

Science Special Issue: Lipid Biology (30 November 2001)

Editorial Guide

  • L. D. Chong, STKE focus issue on lipid biology: Lipids, partners in cellular signaling.
    Sci. STKE 2001, eg5 (2001). [Full Text]

Review

  • D. W. Hilgemann, S. Feng, C. Nasuhoglu, The complex and intriguing lives of PIP2 with ion channels and transporters. Sci. STKE 2001 re19 (2001). [Gloss] [Abstract] [Full Text]

Perspective

  • T. Munnik, A. Musgrave, Phospholipid signaling in plants: Holding on to phospholipase D. Sci. STKE 2001, pe42 (2001). [ Summary] [Full Text]

Forum

  • Lipid Rafts: Real or Artifact? With an opening statement by M. Edidin. [Discussion]

Science Special Issue: Sleep, Dreams, and Memory (2 November 2001)

Editorial Guide

  • J. Nelson, L. Chong, N. Gough, Focus issue on neuroscience: Molecular components of circadian rhythms and oscillations. Sci. STKE 2001, eg4 (2001). [Full Text]

Perspective

  • M. I. Masana, M. L. Dubocovich, Melatonin receptor signaling: Finding the path in the dark. Sci. STKE 2001, pe39 (2001). [Summary] [Full Text]

Review

  • M. P. Pando, P. Sassone-Corsi, Signaling to the mammalian circadian clocks: In pursuit of the primary mammalian circadian photoreceptor. Sci. STKE 2001, re16 (2001). [Gloss] [Abstract] [Full Text]

Science Special Issue: Genome--Unlocking Biology's Storehouse (5 October 2001)

Editorial Guide

  • L. B. Ray, Introduction: STKE focus issue on genomics. Sci. STKE 2001, eg2 (2001). [Full Text]

Perspective

  • K. Ashman, F. Sicheri, T. Pawson, M. Tyers, Cell signaling--The proteomics of it all. Sci. STKE 2001, pe33. [Summary] [Full Text]

Protocol

  • M. L. Matter, M. H. Ginsberg, J. W. Ramos, Identification of cell signaling molecules by expression cloning. Sci. STKE 2001, pl9 (2001). [Abstract] [Full Text]

Science Special Issue: Epigenetics (10 August 2001)

Protocol

  • C. A. Worby, N. Simonson-Leff, J. E. Dixon, RNA interference of gene expression (RNAi) in cultured Drosophila cells. Sci. STKE 2001 pl1 (2001). [Abstract] [Full Text]

Science Special Issue: Vaccines and Immunity (13 July 2001)

Editorial Guide

  • J. W. Nelson, Introduction: STKE focus issue on signaling in the immune system. Sci. STKE 2001, eg1 (2001). [Full Text]

Perspectives

  • A. Z. Fernandis, R. K. Ganju, Slit: A roadblock for chemotaxis. Sci. STKE 2001, pe1 (2001). [Summary] [Full Text]
  • J. W. Nelson, A call to arms: The cytokine selection service. Sci. STKE 2001, pe2 (2001). [Summary] [Full Text]

Connections Maps

  • G. Koretzky, A. L. Singer, T cell signal transduction. Sci. STKE (as seen July 2001), http://stke.sciencemag.org/cgi/cm/CMP_7019. [Canonical Pathway]

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