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Meeting Reports

Highlights from cell signaling meetings and conferences
Cell Biology
The Emergence of the Conserved AAA+ ATPases Pontin and Reptin on the Signaling Landscape
Jean Rosenbaum, Sung Hee Baek, Anindya Dutta, Walid A. Houry, Otmar Huber, Ted R. Hupp, and Pedro M. Matias (12 March 2013)
Sci. Signal. 6 (266), mr1. [DOI: 10.1126/scisignal.2003906]

The AAA+ ATPases Pontin and Reptin play a diverse role in cell biology and signaling.

Wnt signaling
Celebrating 30 Years of Wnt Signaling
Folkert Verkaar, Ken M. Cadigan, and Renée van Amerongen (11 December 2012)
Sci. Signal. 5 (254), mr2. [DOI: 10.1126/scisignal.2003714]

Researchers gathered to share the latest findings on Wnt signaling in development and disease.

Presentations

Slideshows and notes from talks on cell signaling
Cancer
SCF-Mediated Degradation of p100 (NF-κB2): Mechanisms and Relevance in Multiple Myeloma
Luca Busino, Scott E. Millman, and Michele Pagano (4 December 2012)
Sci. Signal. 5 (253), pt14. [DOI: 10.1126/scisignal.2003408]

Ubiquitin-mediated degradation of an inhibitor of noncanonical NF-κB signaling promotes cell survival.

Molecular Biology
Protein Complexes and Target Genes Identification by in Vivo Biotinylation: The STAT5 Paradigm
Eleni Katsantoni (30 October 2012)
Sci. Signal. 5 (248), pt13. [DOI: 10.1126/scisignal.2003622]

Identification of a transcription factor’s interacting partners and target genes can reveal context-specific signaling and transcriptional outputs.

Teaching Resources

Multimedia educational resources for students and instructors
Calcium signaling
CalDyx: An interactive self-study teaching program on calcium dynamics during excitation-contraction coupling in skeletal muscle cells
Stephen M. Baylor (3 February 2015)
Sci. Signal. 8 (362), tr1. [DOI: 10.1126/scisignal.2005839]

Students can explore calcium signaling in slow-twitch, fast-twitch, and superfast-twitch skeletal muscle in response to action potentials.

COMPUTATIONAL BIOLOGY
Using Partial Least Squares Regression to Analyze Cellular Response Data
Pamela K. Kreeger (16 April 2013)
Sci. Signal. 6 (271), tr7. [DOI: 10.1126/scisignal.2003849]

Multivariate data and context-dependent signaling can be analyzed with the computational approach of PLSR.

Podcasts

Conversations with scientists or editors about current research
Cell Migration
Science Signaling Podcast: 26 May 2015
Min Zhao, Peter N. Devreotes, and Annalisa M. VanHook (26 May 2015)
Sci. Signal. 8 (378), pc13. [DOI: 10.1126/scisignal.aac4866]

A genetic screen identifies signaling pathways important for electrotaxis in the slime mold Dictyostelium discoideum.

NEURODEGENERATION
Science Signaling Podcast: 12 May 2015
Kathleen A. Maguire-Zeiss, Stefano G. Daniele, Hang Yin, and Annalisa M. VanHook (12 May 2015)
Sci. Signal. 8 (376), pc12. [DOI: 10.1126/scisignal.aac4242]

Drugs that inhibit signaling by pattern recognition receptors on microglia reduce neuroinflammation associated with synucleinopathies such as Parkinson's disease.

Glossary

An evolving list of acronyms, abbreviations, and other cell signaling terminology
Look up a word by entering the first few characters:

Jobs

Careers in signal transduction from Science Careers
Wed, 27 May 2015
ONJCRI: ONJCRI is recruiting Group Leaders with established track records in fundamental cancer research to strengthen our clinical and laboratory partnership programs. Other
Wed, 27 May 2015
INSERM: Junior postdoctoral positions in Cellular Biophysics/Biochemistry available. France
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