Glossary: D
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D
- DAG:
- stands for diacylglycerol; also known as 1,2-diacylglycerol; an intracellular signaling lipid produced by hydrolysis of membrane lipids; Connections Map Component -- 1,2-Diacylglycerol
- DAPI:
- stands for 4′,6-diamidino-2-phenylindole; a dye that binds nucleic acid and is used to label nuclei
- DARK:
- stands for Drosophila Apaf-1 related killer, part of a complex that activates the initiator caspase DRONC, which leads to apoptosis
- DARPP-32:
- stands for dopamine- and an adenosine 3′,5′-monophosphate (cAMP)-regulated phospho-protein of 32 kilodaltons; cytosolic protein that has been implicated in the regulation of kinase-phosphatase signaling cascades that are modulated by dopamine, glutamate and serotonin
- DCP-1:
- stands for Drosophila caspase 1, an effector caspase involved in apoptosis, is similar in sequence to mammalian caspase-3
- DD:
- stands for death domain; Connections Map Component -- Fas-associated protein with death domain
- DDB1:
- stands for damaged DNA-binding protein 1; a component of ubiquitin ligase complexes
- DDR:
- stands for discoidin domain receptors; Connections Map Component -- Receptor tyrosine protein kinase
- DED:
- stands for death effector domain; Connections Map Component -- Death effector domain-containing DNA binding protein
- DGK:
- stands for diacylglycerol (DAG) kinase; an enzyme that converts DAG to phosphatidic acid; Connections Map Component -- Diacylglycerol kinase
- DGPP:
- stands for diacylglycerol pyrophosphate
- DHA:
- stands for docosahexaenoic acid; an n-3 polyunsaturated fatty acid
- DHHC-CRD:
- stands for Asp-His-His-Cys (DHHC), cysteine-rich domain (CRD); a motif found in a family of proteins with palmitoyl acyl transferase activity and 4 to 6 transmembrane domains
- Dia2:
- a Diaphanous-related formin; formins contribute to actin nucleation and Dia2 is involved in filopodium formation
- DIAP1:
- stands for Drosophila inhibitor of apoptosis protein 1, a fly protein that inhibits the activity of the initiator caspase DRONC and the effector caspases DRICE and DCP-1
- DISC:
- stands for death-inducing signaling complex; a protein complex that is initiated by binding of Fas ligand to its receptor, which ultimately triggers apoptosis
- Dkk:
- stands for Dickkopf; an inhibitor of Wnt signaling; Connections Map Component -- Dickkopf
- DLK:
- stands for dual-leucine-zipper-bearing kinases, a class of mixed lineage kinases (MLKs); Connections Map Components -- Mitogen-activated protein kinase kinase kinase 12 | Mitogen-activated protein kinase kinase kinases
- DLP1:
- stands for dynamin-like protein 1; member of the dynamin family of large GTPases
- DMEM:
- stands for Dulbecco's Modified Eagle's Medium
- DOCK180:
- a member of the CDM (Ced-5 of Caenorhabditis elegans, DOCK180 of mammals, Mbc of Drosophila melanogaster) family of proteins that function as Rac guanine nucleotide exchange factors; Connections Map Component -- DOCK180
- Dpp:
- stands for decapentaplegic; a member of the bone morphogenetic protein family
- DRAM:
- stands for damage-regulated autophagy modulator; a lysosomal transmembrane protein that is involved in autophagy and contributes to p53-mediated cell death
- DRASIC:
- stands for dorsal root acid sensing ion channel; a cation channel that has been implicated in the detection of cutaneous touch
- DREDD:
- stands for death related CED-3/Nedd2-like protein; a caspase in Drosophila melanogaster that may not be critical for apoptosis, but appears to be involved in innate immunity and sperm differentiation
- DRG:
- stands for dorsal root ganglion
- DRICE:
- stands for Drosophila ICE, which is a fly homolog of the interleukin-1β converting enzyme (ICE) and may be an effector caspase in apoptosis
- DRONC:
- stands for Drosophila Nedd2-like caspase, a cysteine protease that participates in apoptosis and is the only initiator caspase in flies
- Drp1:
- stands for dynamin-related protein1; a protein implicated in the regulation of mitochondrial morphology
- dsRBD:
- stands for double-stranded RNA binding domain; Connections Map Component -- Ubiquitin-activating enzyme E1-like
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