Glossary: E

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E

E1:

ubiquitin-activating enzyme; Connections Map Components -- Ubiquitin E2 | APOLLON

E2:

ubiquitin-conjugating enzyme

E3:

ubiquitin ligase

E4BP4:

stands for adenovirus E4 promoter-binding protein 4; a mammalian basic leucine zipper (bZIP) transcription factor

ECFP:

stands for enhanced cyan fluorescent protein

ECM:

stands for extracellular matrix

ECSIT:

stands for evolutionarily conserved signaling intermediate in Toll pathways

EEAC1:

stands for excitatory amino acid carrier 1, a glutamate transporter

eEF2K:

stands for elongation factor-2 kinase; a cytosolic serine-threonine protein kinase involved in translation; Connections Map Component -- Elongation factor-2 kinase

EGF:

stands for epidermal growth factor; Connections Map Components -- Epidermal growth factor | Heparin-binding epidermal growth factor-like growth factor

EGFR:

stands for epidermal growth factor receptor; a receptor tyrosine kinase; Connections Map Component -- Epidermal growth factor receptor

EGR:

stands for early growth response; a transcription factor; Connections Map Component -- Early growth response

EH:

stands for Eps15 homology (EH) domain; a protein interaction domain that binds to peptides containing the amino acid sequence Asp-Pro-Phe (NPF)

eIF2:

stands for eukaryotic translation initiation factor 2; a protein involved in translation

eIF4E:

stands for eukaryotic translation initiation factor 4E; a protein that binds the cap structure of mRNAs and initiates translation; Connections Map Component -- Eukaryotic initiation factor 4E

eIF4G:

stands for eukaryotic translation initiation factor 4 γ; a protein involved in mRNA translation that is sequestered into stress granules in response to certain nonlethal cellular stresses, such as heat or sodium arsenite; Connections Map Component -- eIF4E-binding protein 1

ELC:

stands for essential light chain; a component of filament-forming myosin

ELISA:

stands for enzyme-linked immunosorbent assay; an analytical technique to detect the presence of antigens or antibodies in a sample

ELMO:

stands for engulfment and cell motility, also known as Ced-12; a protein involved in regulation of the cytoskeleton

ENaC:

stands for epithelial sodium channel

eNOS:

stands for endothelial nitric oxide synthase (NOS); an inducible form of NOS

ENTH:

stands for Epsin N-terminal homology; a protein motif that binds phosphoinositide 4,5-bisphosphate (PI(4,5)P₂)

EPAC:

stands for exchange protein directly activated by cAMP (adenosine 3,5-monophosphate); a guanine nucleotide exchange factor for the guanosine triphosphatase Rap that is activated by cAMP; Connections Map Component -- Epac

Epo:

erythropoietin; a hormone that stimulates red blood cell production

EPSC:

stands for excitatory postsynaptic current; postsynaptic response to stimulation of a presynaptic neuron

EREBP:

stands for ethylene response element binding protein; a transcription factor regulated by the plant hormone ethylene; Connections Map Component -- Ethylene Signaling Pathway

ERK:

stands for extracellular signal-regulated kinase; a member of the mitogen-activated protein kinase (MAPK) family of serine-threonine kinases; Connections Map Component -- Mitogen-activated protein kinase

ERK1:

stands for extracellular signal-regulated kinase 1; also known as p42 MAPK; a member of the mitogen-activated protein kinase (MAPK) family of serine-threonine kinases; Connections Map Component -- Extracellular signal-regulated kinase 1

ERK1/2:

stands for extracellular signal-regulated kinase (ERK) 1 and 2; also known as p42/p44 MAPK; members of the mitogen-activated protein kinase (MAPK) family of serine-threonine kinases

ERK2:

stands for extracellular signal-regulated kinase 2; also known as p44 MAPK; a member of the mitogen-activated protein kinase (MAPK) family of serine-threonine kinases; Connections Map Component -- Extracellular signal regulated kinase 2

ESCRT:

stands for endosomal sorting complex required for transport; a macromolecular complex involved in targeting vesicles to multivesicular endosomes

ESE:

stands for exon splicing enhancer; short repeated purine-rich motifs that bind serine-arginine rich (SR) proteins and enhance RNA splicing

ESI:

stands for electrospray ionization; a method for generating intact molecular ions of polar biomolecules directly from solution

ESS:

stands for exon splicing silencer; a sequence that decreases RNA splicing efficiency

EST:

stands for expressed sequence tag; the sequence of a short complementary DNA (cDNA) that represents a portion of a messenger RNA or expressed gene

EVH1:

stands for Ena-VASP homology 1; an ~110 amino-acid domain found in Ena, VASP, WASP, and Homer (also known as Ves1) protein families that binds proteins containing a (D/E)FPPPPX(D/E) motif; Connections Map Component -- Vasodilator-stimulated phosphoprotein

EYFP:

stands for enhanced yellow fluorescent protein

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