Glossary: H
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H
- HDAC:
- stands for histone deacetylase; Connections Map Component -- Histone deacetylase
- HEAT:
- stands for Huntington-elongation factor 1A-protein phosphatase 2A (PP2A) A subunit-TOR repeats; each ~39 amino-acid repeat is believed to form antiparallel a helices that stack in parallel with other repeats to form an ordered array, which may serve to mediate protein-protein interactions
- HECT:
- stands for homology to the papillomavirus E6-associated protein C terminus; defines a family of E3 ubiquitin ligases; Connections Map Component -- Smad ubiquitin regulatory factor
- HER2:
- a member of the family of epidermal growth factor (EGF) receptors, also known as ErbB2 or Neu; Connections Map Component -- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
- HGF:
- stands for hepatocyte growth factor; also known as scatter factor; a secreted protein ligand; Connections Map Component -- Met
- Hhip:
- stands for Hedgehog interacting protein (also abbreviated Hhip1 or Hip1); a transmembrane protein that interacts with Hedgehog to diminish Hedgehog signaling
- HHL:
- stands for N-hexanoyl-L-homoserine; a diffusible quorum signal
- HID:
- stands for head involution defective; a Drosophila antagonist of inhibitor of apoptosis proteins (IAPs), promotes caspase activation, leading to programmed cell death
- HIF-1:
- stands for hypoxia-inducible factor 1; a transcription factor that regulates the expression of target genes in response to hypoxic conditions; Connections Map Component -- Hypoxia-inducible factor 1
- HIPK:
- stands for homeodomain-interacting protein kinase; a serine-threonine protein kinase
- HK:
- stands for histidine kinase; His-containing catalytic protein kinase that mediate His to Asp phosphorelay signaling; Connections Map Component -- Histidine protein kinase
- hKIS:
- stands for human kinase interacting with stathmin; one substrate is the cyclin-dependent kinase inhibitor p27
- HMG:
- stands for high mobility group; an HMG box is a motif found in certain transcription factors; Connections Map Components -- T cell factor | Lymphoid-enhancing factor 1 | Sox
- HNF:
- stands for hepatocyte nuclear factor; a family of transcription factors
- hnRNA:
- stands for heterogeneous nuclear ribonucleic acids; unspliced pre-messenger RNA (pre-mRNA)
- hnRNP:
- stands for heterogeneous nuclear ribonucleoproteins; RNA binding proteins that complex with heterogeneous nuclear ribonucleic acids (hnRNA); Connections Map Component -- Ribonucleoprotein K
- HO-1:
- stands for heme oxygenase 1, an inducible isoform of the enzyme that converts heme to biliverdin-IX
and also produces the signaling gas carbon monoxide (CO)
- HO-2:
- stands for heme oxygenase 2, a constitutively expressed isoform of the enzyme that converts heme to biliverdin-IX and also produces the signaling gas carbon monoxide (CO)
- HPK1:
- stands for hematopoietic progenitor kinase 1
- HPLC:
- stands for high-pressure liquid chromatography
- HPt:
- stands for histidine-containing phosphotransfer protein, also abbreviated HPT; mediates the transfer of phosphate to histidine in His-Asp-His-Asp phosphorelay signaling systems; Connections Map Component -- Histidine phosphotransfer protein
- HRG:
- stands for heregulin; a secreted ligand that binds members of the epidermal growth factor receptor family
- HRI:
- stands for heme-regulated inhibitor; a hemin binding kinase activated by autophosphorylation in response to hemin deficiency
- HSE:
- stands for heat shock element
- HSF-1:
- stands for heat shock factor 1; a transcription factor activated in response to heat shock that stimulates expression of heat shock genes
- HSP:
- stands for heat shock protein; proteins in this family participate in cellular responses to heat and other stresses; Connections Map Components -- Heat shock protein 27 kD | Heat shock protein 90 kD
- HSR1:
- stands for heat shock RNA 1; a noncoding RNA involved in activation of heat shock genes
- HUVEC:
- stands for human umbilical vascular (or vein) endothelial cells
- HVEM:
- stands for herpes virus entry mediator
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