Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2013 American Association for the Advancement of Science 2013-05-21T10:29:05-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Research Article] Estrogen Reduces Lipid Content in the Liver Exclusively from Membrane Receptor Signaling http://stke.sciencemag.org/cgi/content/abstract/6/276/ra36?rss=1 Membrane-localized estrogen receptor can alter metabolism without translocating to the nucleus. Ali Pedram, Mahnaz Razandi, Fiona O'Mahony, Harry Harvey, Brian J. Harvey, Ellis R. Levin [Research Article] Eukaryotic G Protein Signaling Evolved to Require G Protein-Coupled Receptors for Activation http://stke.sciencemag.org/cgi/content/abstract/6/276/ra37?rss=1 As eukaryotic organisms evolved, their G{alpha} proteins switched from being self-activating to requiring an activating receptor. William Bradford, Adam Buckholz, John Morton, Collin Price, Alan M. Jones, Daisuke Urano [Research Article] Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways http://stke.sciencemag.org/cgi/content/abstract/6/276/ra38?rss=1 Comparing protein-interaction networks of two species of yeast suggests that network rewiring may enable environmental adaptation. Jishnu Das, Tommy V. Vo, Xiaomu Wei, Joseph C. Mellor, Virginia Tong, Andrew G. Degatano, Xiujuan Wang, Lihua Wang, Nicolas A. Cordero, Nathan Kruer-Zerhusen, Akihisa Matsuyama, Jeffrey A. Pleiss, Steven M. Lipkin, Minoru Yoshida, Frederick P. Roth, Haiyuan Yu [Review] Sticky Signaling-Adhesion Class G Protein-Coupled Receptors Take the Stage http://stke.sciencemag.org/cgi/content/abstract/6/276/re3?rss=1 Emerging insight on the structural and functional versatility of Adhesion-GPCRs draws a fascinating picture of the multiple signals these molecules transmit. Tobias Langenhan, Gabriela Aust, J{ouml}rg Hamann [Perspective] Understanding the Determinants of Notch Interactions with Its Ligands http://stke.sciencemag.org/cgi/content/abstract/6/276/pe19?rss=1 Multiple regulatory events govern Notch interactions and response to its ligands. Jose F. de Celis [Glossary] http://stke.sciencemag.org/resources/glossary/update_list.dtl?rss=1 Find out what CNA, Mst1, and Sav mean in the world of cell signaling. [Editors' Choice] Hypoxia Prevents miRNA Processing http://stke.sciencemag.org/cgi/content/abstract/6/276/ec111?rss=1 Phosphorylation of a microRNA-processing protein by the EGF receptor inhibits maturation of tumor-suppressing microRNAs. Database of Cell Signaling http://stke.sciencemag.org/cgi/cm/stkecm;CMP_14620?rss=1 High Osmolarity Glycerol (HOG) Pathway in Yeast