Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2009 American Association for the Advancement of Science 2009-07-01T10:01:23-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Editorial Guide] Challenging Times http://stke.sciencemag.org/cgi/content/abstract/2/77/eg8?rss=1 The deluge of NIH "challenge grants" promises to strain the reviewer pool. Michael B. Yaffe [Research Article] Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis http://stke.sciencemag.org/cgi/content/abstract/2/77/ra31?rss=1 Computational modeling of the ErbB signaling network affirms ErbB3 as a therapeutic target. Birgit Schoeberl, Emily A. Pace, Jonathan B. Fitzgerald, Brian D. Harms, Lihui Xu, Lin Nie, Bryan Linggi, Ashish Kalra, Violette Paragas, Raghida Bukhalid, Viara Grantcharova, Neeraj Kohli, Kip A. West, Magdalena Leszczyniecka, Michael J. Feldhaus, Arthur J. Kudla, and Ulrik B. Nielsen [Research Article] PKCε Regulation of an α5 Integrin-ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells http://stke.sciencemag.org/cgi/content/abstract/2/77/ra32?rss=1 Phosphorylated ZO-1 relocalizes from tight junctions to lamellae to associate with α5 integrin and control migration. Saara Tuomi, Anja Mai, Jonna Nevo, Jukka O. Laine, Vesa Vilkki, Tiina J. Öhman, Carl G. Gahmberg, Peter J. Parker, and Johanna Ivaska [Perspective] AIMing 2 Detect Foreign DNA http://stke.sciencemag.org/cgi/content/abstract/2/77/pe39?rss=1 AIM2 is a receptor for cytoplasmic double-stranded DNA and induces the formation of an IL-1β-secreting inflammasome. Arthur M. Krieg [Podcast] Science Signaling Podcast: 30 June 2009 http://stke.sciencemag.org/cgi/content/abstract/2/77/pc12?rss=1 Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Ulrik B. Nielsen and Annalisa M. VanHook [Glossary] http://stke.sciencemag.org/resources/glossary/update_list.dtl?rss=1 Find out what ERM, FMN, and LH mean in the world of cell signaling. [Editors' Choice] Really Random Receptors http://stke.sciencemag.org/content/vol2/issue77/ec212?rss=1 Observations of single receptor molecules show that random membrane insertion can account for highly organized clusters of receptors in bacteria. Database of Cell Signaling: Specific Pathway http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7918?rss=1 Dictyostelium discoideum cAMP Chemotaxis Pathway