Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2008 American Association for the Advancement of Science 2008-05-06T16:46:58-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Perspective] VGF, a New Player in Antidepressant Action? http://stke.sciencemag.org/cgi/content/abstract/1/18/pe19?rss=1 The neuropeptide VGF appears to play a role in the antidepressant effects of exercise, the neurotrophic factor BDNF, and the neurotransmitter serotonin. Jessica E. Malberg and Lisa M. Monteggia [Perspective] Synaptic Patterning by Morphogen Signaling http://stke.sciencemag.org/cgi/content/abstract/1/18/pe20?rss=1 The morphogen Activin acts as a permissive and local motility restriction signal around individual photoreceptor terminals. W. Ryan Williamson and P. Robin Hiesinger [Podcast] http://stke.sciencemag.org/cgi/content/abstract/1/18/pc4?rss=1 Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Elizabeth M. Adler and Annalisa M. VanHook [Editors' Choice] Toxin Targets T Cells http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/18/ec159?rss=1 The aryl hydrocarbon receptor, known for binding environmental toxins, regulates the balance of pro- and anti-inflammatory responses in the immune system. Database of Cell Signaling: Canonical Pathway http://stke.sciencemag.org/cgi/cm/stkecm;CMP_8762?rss=1 Adrenergic Pathway