Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2012 American Association for the Advancement of Science 2012-02-07T10:22:38-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Research Article] Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7 http://stke.sciencemag.org/cgi/content/abstract/5/210/ra11?rss=1 Phosphorylation of the zinc channel ZIP7 releases zinc from the endoplasmic reticulum and promotes signals associated with proliferation and migration. Kathryn M. Taylor, Stephen Hiscox, Robert I. Nicholson, Christer Hogstrand, Peter Kille [Research Article] PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE2-Mediated Inhibition of Phagocytosis of Fungi http://stke.sciencemag.org/cgi/content/abstract/5/210/ra12?rss=1 By promoting actin depolymerization, the protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen. C. Henrique Serezani, Steve Kane, Alexandra I. Medeiros, Ashley M. Cornett, Sang-Hoon Kim, Mariana Morato Marques, Sang-Pyo Lee, Casey Lewis, Emilie Bourdonnay, Megan N. Ballinger, Eric S. White, Marc Peters-Golden [Perspective] An "Inordinate Fondness for Transporters" Explained? http://stke.sciencemag.org/cgi/content/abstract/5/210/pe5?rss=1 The presence of low- and high-affinity transporters enables cells to adequately prepare for nutrient fluctuations. David J. Eide [Podcast] Science Signaling Podcast: 7 February 2012 http://stke.sciencemag.org/cgi/content/abstract/5/210/pc3?rss=1 The kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. Kathryn M. Taylor and Annalisa M. VanHook [Forum] Highlights of Selected Talks Related to Posttranslational Modifications in Cell Signaling http://stke.sciencemag.org/cgi/forum-display/short/stke_el;662?rss=1 These are summaries of presentations from the Cell Signaling Networks 2011 meeting. Nancy R. Gough [Editors' Choice] Starting a Beneficial Path http://stke.sciencemag.org/cgi/content/abstract/5/210/ec40?rss=1 Resveratrol acts as competitive phosphodiesterase inhibitor to initiate pathways that mediate its beneficial effects on metabolic disorders. Database of Cell Signaling http://stke.sciencemag.org/cgi/cm/stkecm;CMP_13296?rss=1 Drosophila Circadian Pathway