Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2009 American Association for the Advancement of Science 2009-11-17T18:07:34-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Research Article] Trypanosoma cruzi Targets Akt in Host Cells as an Intracellular Anti-Apoptotic Strategy http://stke.sciencemag.org/cgi/content/abstract/2/97/ra74?rss=1 A surface protein of the intracellular parasite Trypanosoma cruzi directly interacts with Akt to protect infected cells from pro-apoptotic stimuli. Marina V. Chuenkova and Mercio PereiraPerrin [Research Article] Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. http://stke.sciencemag.org/cgi/content/abstract/2/97/ra73?rss=1 Tyrosine phosphorylation of pyruvate kinase M2 gives tumor cells a metabolic advantage. Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, Jing Chen [Perspective] PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect http://stke.sciencemag.org/cgi/content/abstract/2/97/pe75?rss=1 Aerobic glycolysis in cancer cells is associated with tyrosine phosphorylation of a metabolic enzyme. Chi V. Dang [Perspective] Acetylation Goes Global: The Emergence of Acetylation Biology http://stke.sciencemag.org/cgi/content/abstract/2/97/pe76?rss=1 Proteomic analysis shows protein acetylation to be more prevalent than previously appreciated. Kristi L. Norris, Joo-Yong Lee, Tso-Pang Yao [Glossary] Science Signaling Glossary 17 November 2009 http://stke.sciencemag.org/resources/glossary/update_list.dtl?rss=1 Discover what TRPA, GJIC, and miR mean in the world of signaling. [Editors' Choice] Ensuring Efficient Eating http://stke.sciencemag.org/cgi/content/abstract/2/97/ec366?rss=1 PPAR-δ in macrophages is required to efficiently clear apoptotic cells and to prevent autoimmune responses. Funding Sources http://stke.sciencemag.org/resources/funding/?rss=1 Find grants and other funding opportunities for signaling research and training. Database of Cell Signaling http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18511?rss=1 G Protein Regulation of Disease Resistance During Infection of Rice with Rice Blast Fungus