Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2012 American Association for the Advancement of Science 2012-05-15T11:02:49-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Research Resource] MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma http://stke.sciencemag.org/cgi/content/abstract/5/224/rs4?rss=1 Miniaturized functional genomics uncovers potentially useful combination therapies and drug targets for melanoma. Kris C. Wood, David J. Konieczkowski, Cory M. Johannessen, Jesse S. Boehm, Pablo Tamayo, Olga B. Botvinnik, Jill P. Mesirov, William C. Hahn, David E. Root, Levi A. Garraway, David M. Sabatini [Perspective] The Structure of the Full-Length Tetrameric PKA Regulatory Ri{beta} Complex Reveals the Mechanism of Allosteric PKA Activation http://stke.sciencemag.org/cgi/content/abstract/5/224/pe21?rss=1 The conformational changes caused by cAMP binding to the regulatory subunit in the PKA holoenzyme are shown. Jonathan M. Elkins and Stefan Knapp [Perspective] The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling http://stke.sciencemag.org/cgi/content/abstract/5/224/pe22?rss=1 Structural analysis indicates that the binding sites on a receptor for ligand and inhibitor partially overlap. Ju Bao, Jie J. Zheng, Dianqing Wu [Presentation] Roles of GRK2 in Cell Signaling Beyond GPCR Desensitization: GRK2-HDAC6 Interaction Modulates Cell Spreading and Motility http://stke.sciencemag.org/cgi/content/abstract/5/224/pt3?rss=1 GRK2 modulates tubulin acetylation dynamics in an HDAC6-dependent manner to affect epithelial cell spreading and motility. Petronila Penela, Vanesa Lafarga, Olga Tapia, Veronica Rivas, Laura Nogues, Elisa Lucas, Rocio Vila-Bedmar, Cristina Murga, Federico Mayor Jr. [Glossary] http://stke.sciencemag.org/resources/glossary/update_list.dtl?rss=1 Find out what DSP, K2P, and TAPI mean in the world of cell signaling. [Editors' Choice] A Coactivator Divided http://stke.sciencemag.org/cgi/content/abstract/5/224/ec134?rss=1 A gene encoding a nuclear receptor coactivator split into two separate genes in the fly lineage. Database of Cell Signaling http://stke.sciencemag.org/cgi/cm/stkecm;CMP_6031?rss=1 Xenopus Egg Wnt/{beta}-catenin Pathway