http://stke.sciencemag.org/rss/podcast.xml Periodic audiocasts from Science Signaling, the signal transduction knowledge environment. en-us Tue, 11 Jun 2013 00:01:00 GMT © 2013 American Association for the Advancement of Science swills@aaas.org http://www.sciencemag.org/icons/pic.sub.science-stke.gif http://stke.sciencemag.org/rss/podcast.xml 95 62 Science Signaling Podcast Science Signaling Periodic audiocasts from Science Signaling, the signal transduction knowledge environment. Nancy Gough ngough@aaas.org no http://podcasts.aaas.org/science_signaling/ScienceSignaling_130611.mp3 Brian Button discusses a feedback mechanism for insuring the proper hydration of airway mucus. Science Signaling Brian Button discusses a feedback mechanism for insuring the proper hydration of airway mucus. Brian Button discusses a feedback mechanism for insuring the proper hydration of airway mucus. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130611.mp3 Tue, 11 Jun 2013 00:01:00 GMT no 18:19 Science Signaling, adenosine triphosphate, airway epithelium, ATP, chloride, cilia, hydration, ion channel, mucin, mucus, purine receptor, purinergic signaling, secretion, sodium, viscosity, viscoelasticity http://podcasts.aaas.org/science_signaling/ScienceSignaling_130528.mp3 The tyrosine kinase BMX may act as a global promoter of maximal receptor tyrosine kinase activity. Science Signaling The tyrosine kinase BMX may act as a global promoter of maximal receptor tyrosine kinase activity. The tyrosine kinase BMX may act as a global promoter of maximal receptor tyrosine kinase activity. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130528.mp3 Tue, 28 May 2013 00:01:00 GMT no 16:13 Science Signaling, BMX, peptide library, phosphorylation, phosphotyrosine, protein motif, receptor tyrosine kinase, substrate specificity, tyrosine kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_130514.mp3 A deubiquitinase helps control the inflammatory response. Science Signaling A deubiquitinase helps control the inflammatory response. A deubiquitinase helps control the inflammatory response. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130514.mp3 Tue, 14 May 2013 00:01:00 GMT no 13:18 Science Signaling, adaptor protein, deubiquitinase, deubiquitination, inflammation, inflammatory response, innate immunity, lipopolysaccharide, LPS, septic shock, TLR4, Toll-like receptor 4, ubiquitination, USP25 http://podcasts.aaas.org/science_signaling/ScienceSignaling_130507.mp3 Calcium signaling is required for long-term memory in fruit flies. Science Signaling Calcium signaling is required for long-term memory in fruit flies. Calcium signaling is required for long-term memory in fruit flies. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130507.mp3 Tue, 07 May 2013 00:01:00 GMT no 18:37 Science Signaling, calcium sensor, calcium signaling, Drosophila melanogaster, fruit fly, gene transcription, long-term memory, mushroom body, nucleus, Pavlovian conditioning http://podcasts.aaas.org/science_signaling/ScienceSignaling_130430.mp3 The chemokine scavenging activity of an atypical chemokine receptor requires signaling through β-arrestin. Science Signaling The chemokine scavenging activity of an atypical chemokine receptor requires signaling through β-arrestin. The chemokine scavenging activity of an atypical chemokine receptor requires signaling through β-arrestin. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130430.mp3 Tue, 30 Apr 2013 00:01:00 GMT no 12:26 Science Signaling, beta-arrestin, atypical chemokine receptor D6, biased signaling, cell migration, chemokine gradient, chemokine scavenger, chemotaxis, G protein–coupled receptor, GPCR, immune response, inflammation, leukocyte http://podcasts.aaas.org/science_signaling/ScienceSignaling_130416.mp3 Analysis of VEGF signaling identifies potential therapeutic strategies for treating pathological angiogenesis. Science Signaling Analysis of VEGF signaling identifies potential therapeutic strategies for treating pathological angiogenesis. Analysis of VEGF signaling identifies potential therapeutic strategies for treating pathological angiogenesis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130416.mp3 Tue, 16 Apr 2013 00:01:00 GMT no 16:00 Science Signaling, macular degeneration, angiogenesis, antiangiogenic therapy, blood vessel, cancer, MAP kinase, MAPK, mTOR, pathological angiogenesis, PI 3-kinase, PI3K, vascular endothelial growth factor receptor, vasculogenesis, VEGF, VEGFA, VEGFR http://podcasts.aaas.org/science_signaling/ScienceSignaling_130402.mp3 A multifunctional protein promotes acetylation and activation of the tumor suppressor p53. Science Signaling A multifunctional protein promotes acetylation and activation of the tumor suppressor p53. A multifunctional protein promotes acetylation and activation of the tumor suppressor p53. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130402.mp3 Tue, 02 Apr 2013 00:01:00 GMT no 13:16 Science Signaling, acetyltransferase, apoptosis, cell death, DNA damage, IPMK, inositol polyphosphate multikinase, p300, p53, stress response, transcription, tumor suppressor http://podcasts.aaas.org/science_signaling/ScienceSignaling_130319.mp3 Vitamin E promotes dephosphorylation of the kinase Akt to suppress the growth of prostate cancer cells. Science Signaling Vitamin E promotes dephosphorylation of the kinase Akt to suppress the growth of prostate cancer cells. Vitamin E promotes dephosphorylation of the kinase Akt to suppress the growth of prostate cancer cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130319.mp3 Tue, 19 Mar 2013 00:01:00 GMT no 13:46 Science Signaling, Akt, dephosphorylation, PHLPP1, phosphatase, prostate cancer, PTEN, tocopherol, vitamin E http://podcasts.aaas.org/science_signaling/ScienceSignaling_130312.mp3 Variability in receptor protein abundance affects the sensitivity of T cells to the cytokines IL-2 and IL-7. Science Signaling Variability in receptor protein abundance affects the sensitivity of T cells to the cytokines IL-2 and IL-7. Variability in receptor protein abundance affects the sensitivity of T cells to the cytokines IL-2 and IL-7. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130312.mp3 Tue, 12 Mar 2013 00:01:00 GMT no 18:48 Science Signaling, common gamma chain, cytokine, IL-2, IL-2 receptor alpha, IL-2Ralpha, IL-7, immune response, interleukin-2, interleukin-7, mathematical modeling, protein abundance, T cell differentiation http://podcasts.aaas.org/science_signaling/ScienceSignaling_130219.mp3 Male-type gut microbiota are associated with an increase in testosterone that protects mice from developing type 1 diabetes. Science Signaling Male-type gut microbiota are associated with an increase in testosterone that protects mice from developing type 1 diabetes. Male-type gut microbiota are associated with an increase in testosterone that protects mice from developing type 1 diabetes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130219.mp3 Tue, 19 Feb 2013 00:01:00 GMT no 15:30 Science Signaling, autoimmune disease, autoimmunity, commensal bacteria, gut microbiota, intestinal flora, pancreatic beta cell, testosterone, type 1 diabetes http://podcasts.aaas.org/science_signaling/ScienceSignaling_130212.mp3 In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions. Science Signaling In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions. In addition to mediating the transcriptional response to hypoxia, HIF-1α also inhibits proliferation under oxygen-limiting conditions. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130212.mp3 Tue, 12 Feb 2013 00:01:00 GMT no 13:51 Science Signaling, anoxia, cell proliferation, cell stress, DNA replication, HIF-1alpha, hypoxia, hypoxia-inducible factor 1alpha, transcription factor http://podcasts.aaas.org/science_signaling/ScienceSignaling_130205.mp3 An autophagy receptor specifically targets Salmonella for degradation in infected cells. Science Signaling An autophagy receptor specifically targets Salmonella for degradation in infected cells. An autophagy receptor specifically targets Salmonella for degradation in infected cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130205.mp3 Tue, 05 Feb 2013 00:01:00 GMT no 12:30 Science Signaling, autophagy, cargo receptor, galectin-8, intracellular pathogen, NDP58, Salmonella typhimurium, vesicle, vesicular membrane http://podcasts.aaas.org/science_signaling/ScienceSignaling_130129.mp3 Vemurafenib induces endoplasmic reticulum stress in melanoma cells. Science Signaling Vemurafenib induces endoplasmic reticulum stress in melanoma cells. Vemurafenib induces endoplasmic reticulum stress in melanoma cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130129.mp3 Tue, 29 Jan 2013 00:01:00 GMT no 14:49 Science Signaling, apoptosis, BRAF, BRAFV600E, cancer, cell death, endoplasmic reticulum, ER stress, melanoma, sorafenib, unfolded protein response, UPR, vemurafenib http://podcasts.aaas.org/science_signaling/ScienceSignaling_130115.mp3 Identification of inflammatory response regulators sheds light on disease. Science Signaling Identification of inflammatory response regulators sheds light on disease. Identification of inflammatory response regulators sheds light on disease. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130115.mp3 Tue, 15 Jan 2013 00:01:00 GMT no 15:37 Science Signaling, Blau syndrome, Crohn's disease, inflammation, inflammatory disease, NF-kappaB, NOD2 http://podcasts.aaas.org/science_signaling/ScienceSignaling_130101.mp3 B cell receptor clustering determines which kinases are required for signaling. Science Signaling B cell receptor clustering determines which kinases are required for signaling. B cell receptor clustering determines which kinases are required for signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_130101.mp3 Tue, 01 Jan 2013 00:01:00 GMT no 16:41 Science Signaling, antigen, B cell receptor, BCR, immunoreceptor tyrosine-based activation motif, ITAM, receptor clustering, Src family kinase, SFK, Syk http://podcasts.aaas.org/science_signaling/ScienceSignaling_121127.mp3 A phosphatase implicated in autoiummunity modulates the activities of both effector and regulatory T cells. Science Signaling A phosphatase implicated in autoiummunity modulates the activities of both effector and regulatory T cells. A phosphatase implicated in autoiummunity modulates the activities of both effector and regulatory T cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_121127.mp3 Tue, 27 Nov 2012 00:01:00 GMT no 12:36 Science Signaling, autoimmune disease, autoimmunity, effector T cell, immnuosuppression, phosohatase, PTPN22, regulatory T cell, Treg http://podcasts.aaas.org/science_signaling/ScienceSignaling_121120.mp3 The 2012 Nobel Prize in Chemistry honors research on the function of G protein–coupled receptors. Science Signaling The 2012 Nobel Prize in Chemistry honors research on the function of G protein–coupled receptors. The 2012 Nobel Prize in Chemistry honors research on the function of G protein–coupled receptors. http://podcasts.aaas.org/science_signaling/ScienceSignaling_121120.mp3 Tue, 20 Nov 2012 00:01:00 GMT no 22:02 Science Signaling, adrenergic receptor, beta-arrestin, beta blocker, biased agonism, crystal structure, drug development, G protein–coupled receptor, GPCR, seven transmembrane protein http://podcasts.aaas.org/science_signaling/ScienceSignaling_121106.mp3 A lipid signaling enzyme promotes the growth, vascularization, and metastasis of tumors in mice. Science Signaling A lipid signaling enzyme promotes the growth, vascularization, and metastasis of tumors in mice. A lipid signaling enzyme promotes the growth, vascularization, and metastasis of tumors in mice. http://podcasts.aaas.org/science_signaling/ScienceSignaling_121106.mp3 Tue, 06 Nov 2012 00:01:00 GMT no 14:15 Science Signaling, angiogenesis, blood vessel, cancer, metastasis, phosphatidic acid, phospholipase D1, PLD1, lipid second messenger, tumor microenvironment, vascularization http://podcasts.aaas.org/science_signaling/ScienceSignaling_121030.mp3 Mice lacking an inhibitory receptor have defects in the number, size, and function of platelets. Science Signaling Mice lacking an inhibitory receptor have defects in the number, size, and function of platelets. Mice lacking an inhibitory receptor have defects in the number, size, and function of platelets. http://podcasts.aaas.org/science_signaling/ScienceSignaling_121030.mp3 Tue, 30 Oct 2012 00:01:00 GMT no 16:45 Science Signaling, blood clotting, extracellular matrix, ECM, G6b-B, immunoreceptor tyrosine-based inhibition motif, inhibitory receptor, ITIM, megakaryocyte, platelet http://podcasts.aaas.org/science_signaling/ScienceSignaling_121023.mp3 A growth signal can mediate feedback that reduces cell proliferation and stem cell self-renewal. Science Signaling A growth signal can mediate feedback that reduces cell proliferation and stem cell self-renewal. A growth signal can mediate feedback that reduces cell proliferation and stem cell self-renewal. http://podcasts.aaas.org/science_signaling/ScienceSignaling_121023.mp3 Tue, 23 Oct 2012 00:01:00 GMT no 16:34 Science Signaling, Akt, Bmi1, cancer, chromatin, histone, oncogene, PI3K, PI3-kinase, Polycomb group proteins, self-renewal, stem cell, transcriptional silencing http://podcasts.aaas.org/science_signaling/ScienceSignaling_121009.mp3 The neurotrophic factor BDNF has opposite effects on cocaine- and morphine-induced neuroplasticity. Science Signaling The neurotrophic factor BDNF has opposite effects on cocaine- and morphine-induced neuroplasticity. The neurotrophic factor BDNF has opposite effects on cocaine- and morphine-induced neuroplasticity. http://podcasts.aaas.org/science_signaling/ScienceSignaling_121009.mp3 Tue, 09 Oct 2012 00:01:00 GMT no 13:08 Science Signaling, dopaminergic neuron, drug addiction, BDNF, brain-derived neurotropic factor, cocaine, morphine, neural plasticity, neuroplasticity, synaptic plasticity, TrkB http://podcasts.aaas.org/science_signaling/ScienceSignaling_120911.mp3 The activity of a lipid kinase influences the production of invadopodia by cancer cells. Science Signaling The activity of a lipid kinase influences the production of invadopodia by cancer cells. The activity of a lipid kinase influences the production of invadopodia by cancer cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120911.mp3 Tue, 11 Sep 2012 00:01:00 GMT no 12:32 Science Signaling, cancer, extracellular matrix, focal adhesion, invadopodia, invasion, metastasis, network analysis, phosphatidylinositol 3-kinase, PI3K, PI 3-kinase, PIP3, PKCα, protein kinase C http://podcasts.aaas.org/science_signaling/ScienceSignaling_120828.mp3 A protease can help protect against neurodegeneration by preventing inflammation in microglia. Science Signaling A protease can help protect against neurodegeneration by preventing inflammation in microglia. A protease can help protect against neurodegeneration by preventing inflammation in microglia. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120828.mp3 Tue, 28 Aug 2012 00:01:00 GMT no 14:16 Science Signaling, astrocyte, ERK, MAPK, MEK1, microglia, mnd2 mice, motor neuron degeneration, neurodegeneration, neuroinflammation, Omi, Parkinson's disease, proinflammatory cytokines, protease http://podcasts.aaas.org/science_signaling/ScienceSignaling_120814.mp3 Growth of the male rhinoceros beetle’s horn is more sensitive to insulin signaling than are other body parts. Science Signaling Growth of the male rhinoceros beetle’s horn is more sensitive to insulin signaling than are other body parts. Growth of the male rhinoceros beetle’s horn is more sensitive to insulin signaling than are other body parts. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120814.mp3 Tue, 14 Aug 2012 00:01:00 GMT no 18:31 Science Signaling, growth, horn, insulin pathway, nutrition, rhinoceros beetle, sexual selection, weapon http://podcasts.aaas.org/science_signaling/ScienceSignaling_120807.mp3 Drugs that reduce microtubule density or prevent the production of reactive oxygen species in skeletal muscle might slow the progression of Duchenne muscular dystrophy. Science Signaling Drugs that reduce microtubule density or prevent the production of reactive oxygen species in skeletal muscle might slow the progression of Duchenne muscular dystrophy. Drugs that reduce microtubule density or prevent the production of reactive oxygen species in skeletal muscle might slow the progression of Duchenne muscular dystrophy. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120807.mp3 Tue, 07 Aug 2012 00:01:00 GMT no 15:51 Science Signaling, calcium, cytoskeleton, Duchenne muscular dystrophy, dystrophin, mechanotransduction, microtubule, muscle injury, NADPH oxidase 2, Nox2, reactive oxygen species, regeneration, repair, ROS, X-ROS http://podcasts.aaas.org/science_signaling/ScienceSignaling_120731.mp3 A scaffolding protein enables clustering of IgG B cell receptors to promote antibody secretion by memory B cells. Science Signaling A scaffolding protein enables clustering of IgG B cell receptors to promote antibody secretion by memory B cells. A scaffolding protein enables clustering of IgG B cell receptors to promote antibody secretion by memory B cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120731.mp3 Tue, 31 Jul 2012 00:01:00 GMT no 14:45 Science Signaling, antibody, B cell receptor, BCR, IgG, IgM, immunoglobulin, immunological memory, isotype, memory B cell, PDZ domain, SAP97, scaffold http://podcasts.aaas.org/science_signaling/ScienceSignaling_120724.mp3 A transcription factor protects the heart from radiation-induced damage. Science Signaling A transcription factor protects the heart from radiation-induced damage. A transcription factor protects the heart from radiation-induced damage. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120724.mp3 Tue, 24 Jul 2012 00:01:00 GMT no 14:56 Science Signaling, cancer treatment, cardiac endothelial cell, heart, microvasculature, p53, radiation-induced injury, radiation therapy, side effect, vasculature http://podcasts.aaas.org/science_signaling/ScienceSignaling_120703.mp3 Structural analysis reveals how a Wnt binds to its receptor. Science Signaling Structural analysis reveals how a Wnt binds to its receptor. Structural analysis reveals how a Wnt binds to its receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120703.mp3 Tue, 03 Jul 2012 00:01:00 GMT no 16:22 Science Signaling, Frizzled, Fz, ligand-receptor interaction, lipid, structural biology, Wnt, x-ray crystallography http://podcasts.aaas.org/science_signaling/ScienceSignaling_120626.mp3 An inhibitory receptor blocks proliferation of autoreactive T cells to promote tolerance in the periphery. Science Signaling An inhibitory receptor blocks proliferation of autoreactive T cells to promote tolerance in the periphery. An inhibitory receptor blocks proliferation of autoreactive T cells to promote tolerance in the periphery. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120626.mp3 Tue, 26 Jun 2012 00:01:00 GMT no 19:24 Science Signaling, anergy, autoimmunity, autoreactivity, cell cycle, immune tolerance, PD-1, Programmed Death 1, proliferation, regulatory T cell, T cell receptor http://podcasts.aaas.org/science_signaling/ScienceSignaling_120619.mp3 Modification of a bound lipid modulates the activity of a nuclear receptor. Science Signaling Modification of a bound lipid modulates the activity of a nuclear receptor. Modification of a bound lipid modulates the activity of a nuclear receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120619.mp3 Tue, 19 Jun 2012 00:01:00 GMT no 12:31 Science Signaling, lipid kinase, nuclear receptor, phosphatidylinositol bisphosphate, phospholipid, PIP2, SF-1, steroidogenic factor 1, transcription factor http://podcasts.aaas.org/science_signaling/ScienceSignaling_120612.mp3 Regulated nuclear translocation of a transcription factor maintains lysosomal homeostasis. Science Signaling Regulated nuclear translocation of a transcription factor maintains lysosomal homeostasis. Regulated nuclear translocation of a transcription factor maintains lysosomal homeostasis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120612.mp3 Tue, 12 Jun 2012 00:01:00 GMT no 13:00 Science Signaling, 14-3-3, autophagy, homeostasis, lysosomal storage disease, lysosome, mechanistic target of rapamycin, mTOR, neurodegeneration, nuclear translocation, phosphorylation, TFEB http://podcasts.aaas.org/science_signaling/ScienceSignaling_120522.mp3 Interferon-β therapy is only effective in treating a mouse model of multiple sclerosis when the disease is dependent upon the NLRP3 inflammasome. Science Signaling Interferon-β therapy is only effective in treating a mouse model of multiple sclerosis when the disease is dependent upon the NLRP3 inflammasome. Interferon-β therapy is only effective in treating a mouse model of multiple sclerosis when the disease is dependent upon the NLRP3 inflammasome. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120522.mp3 Tue, 22 May 2012 00:01:00 GMT no 11:22 Science Signaling, autoimmunity, demyelination, IFN-β, inflammasome, inflammation, interferon-β, MS, multiple sclerosis, myelin, neuron, NLRP3 http://podcasts.aaas.org/science_signaling/ScienceSignaling_120508.mp3 Maximal blood vessel dilation can be induced by calcium influx through a just few channel molecules in vascular endothelial cells. Science Signaling Maximal blood vessel dilation can be induced by calcium influx through a just few channel molecules in vascular endothelial cells. Maximal blood vessel dilation can be induced by calcium influx through a just few channel molecules in vascular endothelial cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120508.mp3 Tue, 8 May 2012 00:01:00 GMT no 14:21 Science Signaling, acetylcholine, blood pressure, blood vessel, calcium sparklet, endothelial cell, cation channel, transient receptor potential vanniloid 4, TRPV4, vascular smooth muscle, vascular tone, vasodilation http://podcasts.aaas.org/science_signaling/ScienceSignaling_120501.mp3 Receptor tyrosine kinases existed in the unicellular ancestors of multicellular animals and underwent diversification in the metazoan lineage. Science Signaling Receptor tyrosine kinases existed in the unicellular ancestors of multicellular animals and underwent diversification in the metazoan lineage. Receptor tyrosine kinases existed in the unicellular ancestors of multicellular animals and underwent diversification in the metazoan lineage. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120501.mp3 Tue, 1 May 2012 00:01:00 GMT no 14:13 Science Signaling, animal evolution, choanoflagellate, filasterean, metazoa, multicellularity, protists, tyrosine kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_120410.mp3 New findings elucidate mechanisms by which astrocytes can modulate neuronal activity. Science Signaling New findings elucidate mechanisms by which astrocytes can modulate neuronal activity. New findings elucidate mechanisms by which astrocytes can modulate neuronal activity. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120410.mp3 Tue, 10 Apr 2012 00:01:00 GMT no 20:38 Science Signaling, astrocyte, calcium signaling, diffusion barrier, glia, metabotropic glutamate receptor, mGluR5, neuroglia http://podcasts.aaas.org/science_signaling/ScienceSignaling_120403.mp3 Rapamycin’s effects on longevity and insulin sensitivity are mediated by different molecular targets. Science Signaling Rapamycin’s effects on longevity and insulin sensitivity are mediated by different molecular targets. Rapamycin’s effects on longevity and insulin sensitivity are mediated by different molecular targets. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120403.mp3 Tue, 03 Apr 2012 00:01:00 GMT no 15:02 Science Signaling, glucose tolerance, insulin sensitivity, metabolism, mTOR, mTOR complex, mTORC1, mTORC2, rapamycin, target of rapamycin, TOR http://podcasts.aaas.org/science_signaling/ScienceSignaling_120327.mp3 Regulated protein synthesis and degradation mediate skeletal muscle homeostasis. Science Signaling Regulated protein synthesis and degradation mediate skeletal muscle homeostasis. Regulated protein synthesis and degradation mediate skeletal muscle homeostasis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120327.mp3 Tue, 27 Mar 2012 00:01:00 GMT no 14:37 Science Signaling, atrophy, cachexia, Galphai2, G protein, homeostasis, hypertrophy, MNK2, mTOR, mTORC1, muscle wasting, protein translation, regeneration, target of rapamycin http://podcasts.aaas.org/science_signaling/ScienceSignaling_120306.mp3 Signaling from two growth factors converges on the cell cycle inhibitor p57 to regulate proliferation and limit oncogenesis. Science Signaling Signaling from two growth factors converges on the cell cycle inhibitor p57 to regulate proliferation and limit oncogenesis. Signaling from two growth factors converges on the cell cycle inhibitor p57 to regulate proliferation and limit oncogenesis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120306.mp3 Tue, 06 Mar 2012 00:01:00 GMT no 12:06 Science Signaling, Akt, breast cancer, cell cycle inhibitor, EGF, epidermal growth factor, ERK, IGF-1, insulin-like growth factor 1, mammalian target of rapamycin, mammary epithelial cells, mTOR, p57, PI3 kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_120214.mp3 The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization. Science Signaling The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization. The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120214.mp3 Tue, 14 Feb 2012 00:01:00 GMT no 15:28 Science Signaling, actin depolymerizing factor, Candida albicans, cofilin, immunocompromise, immunosuppression, innate immunity, lung infection, macrophage, pathogen, PGE2, phagocytosis, prostaglandin E2, PTEN http://podcasts.aaas.org/science_signaling/ScienceSignaling_120207.mp3 Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. Science Signaling Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120207.mp3 Tue, 07 Feb 2012 00:01:00 GMT no 15:03 Science Signaling, breast cancer, casein kinase 2, CK2, migration, proliferation, second messenger, zinc transporter, ZIP7 http://podcasts.aaas.org/science_signaling/ScienceSignaling_120131.mp3 Signaling through PAS kinases bypasses the pro-growth requirement of Tor2 in yeast. Science Signaling Signaling through PAS kinases bypasses the pro-growth requirement of Tor2 in yeast. Signaling through PAS kinases bypasses the pro-growth requirement of Tor2 in yeast. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120131.mp3 Tue, 31 Jan 2012 00:01:00 GMT no 16:38 Science Signaling, cell wall synthesis, genetic screen, growth, overexpression, PAS kinase, Psk1, Psk2, Rho1, stress, target of rapamycin, TOR, Tor2, Ugp1, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_120110.mp3 Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies. Science Signaling Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies. Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120110.mp3 Tue, 10 Jan 2012 00:01:00 GMT no 13:48 Science Signaling, apoptosis, beta-catenin, BRAF, cell death, chemotherapy, ERK, extracellular signal-regulated kinase, kinase inhibitor, MAP kinase, mitogen-activated protein kinase, melanocyte, melanoma, metastasis, neural crest, skin cancer, Wnt http://podcasts.aaas.org/science_signaling/ScienceSignaling_11220.mp3 Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor. Science Signaling Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor. Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111220.mp3 Tue, 20 Dec 2011 00:01:00 GMT no 16:25 Science Signaling, autoimmunity, calcium, cancer, conventional T cell, regulatory T cell, suppression, T cell receptor, Tcon, TCR, Treg http://podcasts.aaas.org/science_signaling/ScienceSignaling_111129.mp3 Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling. Science Signaling Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling. Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111129.mp3 Tue, 29 Nov 2011 00:01:00 GMT no 15:05 Science Signaling, calcium-sensing receptor, CaSR, endocytosis, exocytosis, G protein-coupled receptor, GPCR, parathyroid hormone, trafficking http://podcasts.aaas.org/science_signaling/ScienceSignaling_111108.mp3 The vacuolar ATPase is required for amino acid-mediated activation of mTORC1. Science Signaling The vacuolar ATPase is required for amino acid-mediated activation of mTORC1. The vacuolar ATPase is required for amino acid-mediated activation of mTORC1. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111108.mp3 Tue, 08 Nov 2011 00:01:00 GMT no 10:40 Science Signaling, amino acid sensing, GTPase, lysosome, mammalian target of rapamycin complex 1, mTORC1, proton pump, Rag, Ragulator, Rheb, vacuolar ATPase, V-ATPase http://podcasts.aaas.org/science_signaling/ScienceSignaling_111101.mp3 An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor. Science Signaling An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor. An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111101.mp3 Tue, 01 Nov 2011 00:01:00 GMT no 15:14 Science Signaling, Act1, chemokine, cytokine, IL-17, IL-25, inflammation, Interleukin-17, Interleukin-25, peptide, T cell http://podcasts.aaas.org/science_signaling/ScienceSignaling_111025.mp3 A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila. Science Signaling A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila. A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111025.mp3 Tue, 25 Oct 2011 00:01:00 GMT no 16:23 Science Signaling, Drosophila melanogaster, ERK, extracellular signal-regulated kinase, fruit fly, MAPK, MAP kinase, mass spectrometry, mitogen-activated protein kinase, proteomics, Ras, RNAi, RNA interference, screen http://podcasts.aaas.org/science_signaling/ScienceSignaling_111011.mp3 Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling. Science Signaling Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling. Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111011.mp3 Tue, 11 Oct 2011 00:01:00 GMT no 12:32 Science Signaling, antagonism, BMP, bone morphogenetic protein, Decapentaplegic, Dpp, development, glycogen synthase kinase, GSK-3, Mad, morphogen gradient, Mothers against Dpp, phosphorylation, Wg, Wingless, Wnt http://podcasts.aaas.org/science_signaling/ScienceSignaling_111004.mp3 By working together, cells can overcome the loss of information as it flows through a signaling network. Science Signaling By working together, cells can overcome the loss of information as it flows through a signaling network. By working together, cells can overcome the loss of information as it flows through a signaling network. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111004.mp3 Tue, 04 Oct 2011 00:01:00 GMT no 15:50 Science Signaling, biochemical network, bottleneck, information flow, modeling, systems biology, TNF, tumor necrosis factor alpha http://podcasts.aaas.org/science_signaling/ScienceSignaling_110920.mp3 Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells. Science Signaling Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells. Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110920.mp3 Tue, 20 Sep 2011 00:01:00 GMT no 13:43 Science Signaling, breast cancer, chemokine, CXCR4, fasudil, G protein, metastasis, Rho, SDF-1 http://podcasts.aaas.org/science_signaling/ScienceSignaling_110913.mp3 Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade. Science Signaling Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade. Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110913.mp3 Tue, 13 Sep 2011 00:01:00 GMT no 15:49 Science Signaling, differentiation, EGF, epidermal growth factor, ERK, extracellular signal-regulated kinase, methyltransferase, nerve growth factor, NGF, PC12 cells, PRMT5, proliferation, RAF, RAS http://podcasts.aaas.org/science_signaling/ScienceSignaling_110906.mp3 Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation. Science Signaling Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation. Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110906.mp3 Tue, 06 Sep 2011 00:01:00 GMT no 16:03 Science Signaling, adhesion, CD11b/CD18, inflammation, inflammatory disease, injury, integrin, leukocyte, migration http://podcasts.aaas.org/science_signaling/ScienceSignaling_110823.mp3 β2 subunit-containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus. Science Signaling β2 subunit-containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus. β2 subunit-containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110823.mp3 Tue, 23 Aug 2011 00:01:00 GMT no 10:54 Science Signaling, Alzheimer’s disease, attentional focus, cholinergic signaling, cognition, dementia, medial prefrontal cortex, nicotinic acetylcholine receptor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110809.mp3 Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide. Science Signaling Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide. Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110809.mp3 Tue, 09 Aug 2011 00:01:00 GMT no 12:53 Science Signaling, endocytosis, morphine, Mu-type opioid receptor, opiate, partial agonist, phosphorylation http://podcasts.aaas.org/science_signaling/ScienceSignaling_110726.mp3 A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation. Science Signaling A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation. A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110726.mp3 Tue, 26 Jul 2011 00:01:00 GMT no 16:30 Science Signaling, cancer, chemotherapy, Cdk5, cyclin-dependent kinase, invadopodia, invasion, metastasis, paclitaxel, Taxol http://podcasts.aaas.org/science_signaling/ScienceSignaling_110705.mp3 The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling. Science Signaling The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling. The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110705.mp3 Tue, 05 Jul 2011 00:01:00 GMT no 10:49 Science Signaling, asthma, chloroquine, combination therapy, dexamethasone, glucocorticoid receptor, inflammation, inflammatory arthritis http://podcasts.aaas.org/science_signaling/ScienceSignaling_110628.mp3 Two studies shed light on cell cycle-dependent protein phosphorylation during mitosis in yeast. Science Signaling Two studies shed light on cell cycle-dependent protein phosphorylation during mitosis in yeast. Two studies shed light on cell cycle-dependent protein phosphorylation during mitosis in yeast. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110628.mp3 Tue, 28 Jun 2011 00:01:00 GMT no 19:27 Science Signaling, Aurora, cell cycle, centrosome, kinase, mitosis, phosphoproteome, phosphoproteomics, protein phosphorylation, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_110614.mp3 Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes. Science Signaling Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes. Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110614.mp3 Tue, 14 Jun 2011 00:01:00 GMT no 13:03 Science Signaling, crystal structure, F-actin, filamentous, G-actin, MRTF-A, nucleocytoplasmic shuttling, RPEL domain, structural biology, transcriptional coactivator, transcription factor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110524.mp3 Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap. Science Signaling Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap. Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110524.mp3 Tue, 24 May 2011 00:01:00 GMT no 16:24 Science Signaling, alpha-catenin, alphaE-catenin, beta-catenin, cancer, cell proliferation, development, growth control, heart, Hippo, keratinocyte, mouse, organ size, skin cancer, squamous call carcinoma, Wnt, Yap1 http://podcasts.aaas.org/science_signaling/ScienceSignaling_110503.mp3 Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation. Science Signaling Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation. Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110503.mp3 Tue, 03 May 2011 00:01:00 GMT no 15:01 Science Signaling, adjuvant, endotoxin, immune response, inflammasome, inflammation, interleukin-1, IL-1, lipopolysaccharide, LPS, monophosphoryl lipid A, MLA, MyD88, Toll-like receptor 4, TLR4, TRIF, vaccine http://podcasts.aaas.org/science_signaling/ScienceSignaling_110426.mp3 A growth factor that antagonizes signaling by tumor necrosis factor α relieves symptoms of inflammatory arthritis. Science Signaling A growth factor that antagonizes signaling by tumor necrosis factor α relieves symptoms of inflammatory arthritis. A growth factor that antagonizes signaling by tumor necrosis factor α relieves symptoms of inflammatory arthritis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110426.mp3 Tue, 26 Apr 2011 00:01:00 GMT no 11:58 Science Signaling, cytokine, growth factor, inflammation, inflammatory arthritis, progranulin, rheumatoid arthritis, tumor necrosis factor alpha, tumor necrosis factor receptor, TNFalpha, TNFR, TNF inhibitor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110405.mp3 The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors. Science Signaling The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors. The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110405.mp3 Tue, 05 Apr 2011 00:01:00 GMT no 14:32 Science Signaling, autoimmunity, autoreactivity, immune tolerance, lipid draft, major histocompatibility complex class I, microdomain, nanodomain, MHC class I, natural killer cell, NK cell, plasma membrane, receptor, self-tolerance http://podcasts.aaas.org/science_signaling/ScienceSignaling_110329.mp3 Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. Science Signaling Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110329.mp3 Tue, 29 Mar 2011 00:01:00 GMT no 12:39 Science Signaling, B-ALL, B cell acute lymphoblastic leukemia, Bcr-Abl, cancer, chronic myelogenous leukemia, CML, network, phosphoproteomics, Src family kinase, tyrosine kinase inhibitor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110315.mp3 A protein required for light sensation also plays a role in thermosensing in the fruit fly. Science Signaling A protein required for light sensation also plays a role in thermosensing in the fruit fly. A protein required for light sensation also plays a role in thermosensing in the fruit fly. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110315.mp3 Tue, 15 Mar 2011 00:01:00 GMT no 13:58 Science Signaling, Drosophila melanogaster, fruit fly, light, photoreception, rhodopsin, temperature, thermosensation, thermotaxis, transient receptor potential channel, TRP http://podcasts.aaas.org/science_signaling/ScienceSignaling_110308.mp3 Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. Science Signaling Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110308.mp3 Tue, 08 Mar 2011 00:01:00 GMT no 14:59 Science Signaling, Decapentaplegic, disc, Dpp, Drosophila, fly, gradient, mathematical modeling, morphogen, proliferation, wing http://podcasts.aaas.org/science_signaling/ScienceSignaling_110222.mp3 A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli. Science Signaling A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli. A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110222.mp3 Tue, 22 Feb 2011 00:01:00 GMT no 15:03 Science Signaling, antiviral response, innate immunity, interferon response element, interferon regulatory factor, IRE, IRF, NF-kappaB, nuclear factor kappaB http://podcasts.aaas.org/science_signaling/ScienceSignaling_110125.mp3 Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. Science Signaling Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110125.mp3 Tue, 25 Jan 2011 00:01:00 GMT no 12:43 Science Signaling, fasudil, obesity, hypothalamus, inflammation, insulin resistance, mechanical stretch, mechanotransduction, metabolism, osmolarity, Rho, Rho-kinase, vasopressin http://podcasts.aaas.org/science_signaling/ScienceSignaling_110104.mp3 Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. Science Signaling Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110104.mp3 Tue, 04 Jan 2011 00:01:00 GMT no 13:25 Science Signaling, experiments, research articles, review http://podcasts.aaas.org/science_signaling/ScienceSignaling_101221.mp3 Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast. Science Signaling Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast. Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101221.mp3 Tue, 21 Dec 2010 00:01:00 GMT no 14:01 Science Signaling, kinase, network analysis, phosphatase, phosphoproteome, proteome, systems biology, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_101207.mp3 Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins. Science Signaling Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins. Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101207.mp3 Tue, 07 Dec 2010 00:01:00 GMT no 15:06 Science Signaling, 19S, 20S, 26S, catalytic particle, cell stress, degradation, hydrogen peroxide, oxidation, proteasome, protein damage, regulatory particle, ubiquitin, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_101123.mp3 Targeting interactions between HLA-I and the integrin beta4 subunit is a potential strategy for preventing transplant rejection. Science Signaling Targeting interactions between HLA-I and the integrin beta4 subunit is a potential strategy for preventing transplant rejection. Targeting interactions between HLA-I and the integrin beta4 subunit is a potential strategy for preventing transplant rejection. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101123.mp3 Tue, 23 Nov 2010 00:01:00 GMT no 12:10 Science Signaling, angiogenesis, atherosclerosis, endothelial cell, HLA, human leukocyte antigen, integrin, organ transplant, rejection, vasculopathy http://podcasts.aaas.org/science_signaling/ScienceSignaling_101109.mp3 A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease. Science Signaling A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease. A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101109.mp3 Tue, 09 Nov 2010 00:01:00 GMT no 12:16 Science Signaling, action potential, ATP, axon, glia, neuron, nonvesicular, membrane stretch, swelling, synapse, volume-activated anion channel http://podcasts.aaas.org/science_signaling/ScienceSignaling_101026.mp3 Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy. Science Signaling Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy. Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101026.mp3 Tue, 26 Oct 2010 00:01:00 GMT no 9:51 Science Signaling, angiogenesis, ARAP3, blood vessel, PI3 kinase, vasculature, vascular system, vasculogenesis http://podcasts.aaas.org/science_signaling/ScienceSignaling_101005.mp3 Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke. Science Signaling Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke. Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101005.mp3 Tue, 05 Oct 2010 00:01:00 GMT no 11:29 Science Signaling, apolipoprotein-E, ApoE, ApoE receptor, blood-brain barrier, drug delivery, ischemia, permeability, stroke http://podcasts.aaas.org/science_signaling/ScienceSignaling_100824.mp3 A phosphoprotemic approach identifies potential targets for developing combination therapies to treat cancer. Science Signaling A phosphoprotemic approach identifies potential targets for developing combination therapies to treat cancer. A phosphoprotemic approach identifies potential targets for developing combination therapies to treat cancer. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100824.mp3 Tue, 24 Aug 2010 00:01:00 GMT no 11:42 Science Signaling, cancer, drug targets, proteomics, receptor tyrosine kinase, RTK, screen, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_100803.mp3 A virally-encoded G protein-coupled receptor promotes cellular proliferation and vascularization. Science Signaling A virally-encoded G protein-coupled receptor promotes cellular proliferation and vascularization. A virally-encoded G protein-coupled receptor promotes cellular proliferation and vascularization. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100803.mp3 Tue, 03 Aug 2010 00:01:00 GMT no 6:47 Science Signaling, cancer, cell proliferation, chemokine, G protein-coupled receptor, GPCR, HCMV, human cytomegalovirus, tumor, US28, vascularization http://podcasts.aaas.org/science_signaling/ScienceSignaling_100720.mp3 Network redundancies lend robustness to the neuronal injury response. Science Signaling Network redundancies lend robustness to the neuronal injury response. Network redundancies lend robustness to the neuronal injury response. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100720.mp3 Tue, 20 Jul 2010 00:01:00 GMT no 10:07 Science Signaling, growth, injury, network, neurite, neuron, phosphoproteomics, regeneration, repair, retrograde transport http://podcasts.aaas.org/science_signaling/ScienceSignaling_100706.mp3 Lateral inhibition in proneuronal clusters in the fruit fly relies on competition between cis and trans Notch signaling. Science Signaling Lateral inhibition in proneuronal clusters in the fruit fly relies on competition between cis and trans Notch signaling. Lateral inhibition in proneuronal clusters in the fruit fly relies on competition between cis and trans Notch signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100706.mp3 Tue, 6 Jul 2010 00:01:00 GMT no 13:53 Science Signaling, bristle, computational biology, Delta, Drosophila melanogaster, fruit fly, lateral inhibition, mathematical modeling, Notch, proneural cluster, sensory organ precursor, SOP http://podcasts.aaas.org/science_signaling/ScienceSignaling_100629.mp3 Analysis of TOR signaling pathway evolution may shed light on the early divergence of eukaryotic lineages. Science Signaling Analysis of TOR signaling pathway evolution may shed light on the early divergence of eukaryotic lineages. Analysis of TOR signaling pathway evolution may shed light on the early divergence of eukaryotic lineages. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100629.mp3 Tue, 29 Jun 2010 00:01:00 GMT no 15:17 Science Signaling, bikont, Amoebozoa, Archaeplastida, Chromalveolata, eukaryote, evolution, Excavata, Opisthokonta, target of rapamycin, TOR pathway, unikont http://podcasts.aaas.org/science_signaling/ScienceSignaling_100608.mp3 Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating beta-arrestin-dependent signaling. Science Signaling Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating beta-arrestin-dependent signaling. Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating beta-arrestin-dependent signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100608.mp3 Tue, 8 Jun 2010 00:01:00 GMT no 19:32 Science Signaling, angiotensin, AT1R, beta-arrestin, blood pressure, cell survival, G protein-coupled receptor, GPCR, hypertension, mechanical stress, mechanotransduction http://podcasts.aaas.org/science_signaling/ScienceSignaling_100525.mp3 The balance between WNT and FGF signaling influences the mode of bone formation in the skull. Science Signaling The balance between WNT and FGF signaling influences the mode of bone formation in the skull. The balance between WNT and FGF signaling influences the mode of bone formation in the skull. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100525.mp3 Tue, 25 May 2010 00:01:00 GMT no 10:13 Science Signaling, bone, chondrocyte, cranium, craniosynostosis, endochondral bone, FGF, intramembranous ossification, skull suture, WNT http://podcasts.aaas.org/science_signaling/ScienceSignaling_100511.mp3 Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis. Science Signaling Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis. Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100511.mp3 Tue, 11 May 2010 00:01:00 GMT no 16:34 Science Signaling, anchor cell invasion, Caenorhabditis elegans, cell invasion, invadopodia, invasiveness, metastasis, nematode, vulva, worm http://podcasts.aaas.org/science_signaling/ScienceSignaling_100504.mp3 Ammonia induces autophagy, which may help cancer cells survive stressful conditions. Science Signaling Ammonia induces autophagy, which may help cancer cells survive stressful conditions. Ammonia induces autophagy, which may help cancer cells survive stressful conditions. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100504.mp3 Tue, 04 May 2010 00:01:00 GMT no 15:26 Science Signaling, ammonia, autophagy, cancer, glutaminolysis, metabolism, mTOR, starvation, tumor http://podcasts.aaas.org/science_signaling/ScienceSignaling_100420.mp3 Integrating interactome and genetics data allows researchers to predict adverse drug effects. Science Signaling Integrating interactome and genetics data allows researchers to predict adverse drug effects. Integrating interactome and genetics data allows researchers to predict adverse drug effects. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100420.mp3 Tue, 20 Apr 2010 00:01:00 GMT no 14:30 Science Signaling, adverse effects, cardiac arrhythmia, drug, ion channel, long QT syndrome, side effect, single nucleotide polymorphism, SNP http://podcasts.aaas.org/science_signaling/ScienceSignaling_100330.mp3 The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion. Science Signaling The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion. The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100330.mp3 Tue, 30 Mar 2010 00:01:00 GMT no 16:29 Science Signaling, adhesion, AMP kinase, LKB1, myosin phosphatase, NUAK, Peutz-Jeghers syndrome, phosphorylation, proliferation, tumor suppressor http://podcasts.aaas.org/science_signaling/ScienceSignaling_100316.mp3 Reduction of ankyrin-B activity impairs maximal insulin release and is a risk factor for diabetes. Science Signaling Reduction of ankyrin-B activity impairs maximal insulin release and is a risk factor for diabetes. Reduction of ankyrin-B activity impairs maximal insulin release and is a risk factor for diabetes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100316.mp3 Tue, 16 Mar 2010 00:01:00 GMT no 14:42 Science Signaling, acetylcholine, beta cells, cholinergic, glucose, insulin secretion, islet cells, pancreas, parasympathetic nervous system, vagus nerve http://podcasts.aaas.org/science_signaling/ScienceSignaling_100223.mp3 Dying cells release signals that stimulate cellular proliferation in regenerating tissues. Science Signaling Dying cells release signals that stimulate cellular proliferation in regenerating tissues. Dying cells release signals that stimulate cellular proliferation in regenerating tissues. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100223.mp3 Tue, 23 Feb 2010 00:01:00 GMT no 12:40 Science Signaling, apoptosis, proliferation, regeneration, wound healing http://podcasts.aaas.org/science_signaling/ScienceSignaling_100216.mp3 The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk. Science Signaling The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk. The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100216.mp3 Tue, 16 Feb 2010 00:01:00 GMT no 16:26 Science Signaling, atherosclerosis, complement, gingivitis, innate immunity, periodontitis, Porphyromonas gingivalis, Toll-like receptor 2 http://podcasts.aaas.org/science_signaling/ScienceSignaling_100202.mp3 A noncoding RNA competes with DNA for binding to the glucocorticoid receptor. Science Signaling A noncoding RNA competes with DNA for binding to the glucocorticoid receptor. A noncoding RNA competes with DNA for binding to the glucocorticoid receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100202.mp3 Tue, 02 Feb 2010 00:01:00 GMT no 13:47 Science Signaling, DNA binding, glucocorticoid response element, GRE, hormone, noncoding RNA, nuclear receptor, transcription factor http://podcasts.aaas.org/science_signaling/ScienceSignaling_100126.mp3 A single amino acid substitution in a viral protein is sufficient to attenuate rabies virulence. Science Signaling A single amino acid substitution in a viral protein is sufficient to attenuate rabies virulence. A single amino acid substitution in a viral protein is sufficient to attenuate rabies virulence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100126.mp3 Tue, 26 Jan 2010 00:01:00 GMT no 12:36 Science Signaling, apoptosis, attenuation, cell death, neuron, rabies, virulence, virus http://podcasts.aaas.org/science_signaling/ScienceSignaling_100105.mp3 Chief Scientific Editor Michael Yaffe reviews the year in Science Signaling. Science Signaling Chief Scientific Editor Michael Yaffe reviews the year in Science Signaling. Chief Scientific Editor Michael Yaffe reviews the year in Science Signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100105.mp3 Tue, 05 Jan 2010 00:01:00 GMT no 12:20 Science Signaling, breakthrough, experiments, research articles, technologies http://podcasts.aaas.org/science_signaling/ScienceSignaling_091215.mp3 Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling. Science Signaling Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling. Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091215.mp3 Tue, 15 Dec 2009 00:01:00 GMT no 16:59 Science Signaling, epidermal growth factor receptor (EGFR), glioblastoma, lapatinib, lipid biosynthesis, sterol regulatory element-binding protein 1 (SREBP1) http://podcasts.aaas.org/science_signaling/ScienceSignaling_091201.mp3 Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue. Science Signaling Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue. Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091201.mp3 Tue, 01 Dec 2009 00:01:00 GMT no 14:17 Science Signaling, adipose tissue, brown fat, energy, lipids, preadipocyte, thermogenesis http://podcasts.aaas.org/science_signaling/ScienceSignaling_091124.mp3 Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change. Science Signaling Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change. Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091124.mp3 Tue, 24 Nov 2009 00:01:00 GMT no 19:32 Science Signaling, evolution, modularity, protein domain, proteomics http://podcasts.aaas.org/science_signaling/ScienceSignaling_091110.mp3 The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. Science Signaling The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091110.mp3 Tue, 10 Nov 2009 00:01:00 GMT no 19:01 Science Signaling, gasotransmitter, hydrogen sulfide, posttranslational modification, sulfhydration, vasorelaxant http://podcasts.aaas.org/science_signaling/ScienceSignaling_091027.mp3 Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. Science Signaling Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091027.mp3 Tue, 27 Oct 2009 00:01:00 GMT no 13:37 Science Signaling, aging, cell proliferation, mitogen-activated protein kinase kinase 4, Mek4, MKK4, microRNA, replicative senescence http://podcasts.aaas.org/science_signaling/ScienceSignaling_091013.mp3 Distinct Src kinases regulate the differentiation of embryonic stem cells. Science Signaling Distinct Src kinases regulate the differentiation of embryonic stem cells. Distinct Src kinases regulate the differentiation of embryonic stem cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091013.mp3 Tue, 13 Oct 2009 00:01:00 GMT no 15:32 Science Signaling, c-Src, c-Yes, development, differentiation, embryonic stem cell, primitive ectoderm, Src kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_091006.mp3 Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. Science Signaling Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091006.mp3 Tue, 06 Oct 2009 00:01:00 GMT no 15:46 Science Signaling, cell proliferation, Drosophila, fruit fly, gradient, morphogen, patterning, Wingless http://podcasts.aaas.org/science_signaling/ScienceSignaling_090908.mp3 Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. Science Signaling Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090908.mp3 Tue, 08 Sep 2009 00:01:00 GMT no 15:00 Science Signaling, evolution, multicellular, mutagenesis, PDZ domain, protein-protein interaction network http://podcasts.aaas.org/science_signaling/ScienceSignaling_090818.mp3 Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. Science Signaling Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090818.mp3 Tue, 18 Aug 2009 00:01:00 GMT no 19:27 Science Signaling, phosphoproteomics, phosphorylation, protein-protein interaction, proteomics, systems biology, T cell activation, T cell receptor, TCR http://podcasts.aaas.org/science_signaling/ScienceSignaling_090728.mp3 Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.. Science Signaling Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.. Science Signaling's Chief Scientific Editor discusses complexity in signaling networks. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090728.mp3 Tue, 28 Jul 2009 00:01:00 GMT no 12:43 Science Signaling, complexity, dynamics, interactome, network, protein-protein interaction http://podcasts.aaas.org/science_signaling/ScienceSignaling_090721.mp3 A small G protein may limit the toxicity of mutant huntingtin to the brain. Science Signaling A small G protein may limit the toxicity of mutant huntingtin to the brain. A small G protein may limit the toxicity of mutant huntingtin to the brain. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090721.mp3 Tue, 21 Jul 2009 00:01:00 GMT no 5:53 Science Signaling, Alzheimer's disease, huntingtin, Huntington's disease, neurodegeneration, Parkinson's disease http://podcasts.aaas.org/science_signaling/ScienceSignaling_090630.mp3 Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Science Signaling Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090630.mp3 Tue, 30 Jun 2009 00:01:00 GMT no 14:13 Science Signaling, cancer, drug target, EGFR, ErbB, mathematical modeling, systems biology http://podcasts.aaas.org/science_signaling/ScienceSignaling_090623.mp3 A microfluidic device enables high-throughput analysis of signaling in individual cells. Science Signaling A microfluidic device enables high-throughput analysis of signaling in individual cells. A microfluidic device enables high-throughput analysis of signaling in individual cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090623.mp3 Tue, 23 Jun 2009 00:01:00 GMT no 17:27 Science Signaling, engineering, microfabrication, microfluidic device, protocol http://podcasts.aaas.org/science_signaling/ScienceSignaling_090609.mp3 Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. Science Signaling Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090609.mp3 Tue, 09 Jun 2009 00:01:00 GMT no 24:14 Science Signaling, allergy, degranulation, mast cell, phosphatidylinositol. phosphoinositide, PIP2, PIP3, PI3 kinase, second messenger http://podcasts.aaas.org/science_signaling/ScienceSignaling_090519.mp3 TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. Science Signaling TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090519.mp3 Tue, 19 May 2009 00:01:00 GMT no 14:26 Science Signaling, TRP channel, TRPM1, melanin, melanocyte, melanoma, melastatin, pigment http://podcasts.aaas.org/science_signaling/ScienceSignaling_090421.mp3 Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. Science Signaling Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090421.mp3 Tue, 21 Apr 2009 00:01:00 GMT no 22:55 Science Signaling, mammalian target of rapamycin, mTOR, mTORC1, mTORC2, cancer, immunology, inhibitors, kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_090407.mp3 The sets of kinases required by different cancer cell lines are highly divergent. Science Signaling The sets of kinases required by different cancer cell lines are highly divergent. The sets of kinases required by different cancer cell lines are highly divergent. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090407.mp3 Tue, 07 Apr 2009 00:01:00 GMT no 11:59 Science Signaling, kinome, kinase, cancer, screen http://podcasts.aaas.org/science_signaling/ScienceSignaling_090324.mp3 The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. Science Signaling The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090324.mp3 Tue, 24 Mar 2009 00:01:00 GMT no 14:10 Science Signaling, Mycobacterium tuberculosis, forkhead-associated domain, FHA, phosphorylation, phosphothreonine, kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_090303.mp3 Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. Science Signaling Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090303.mp3 Tue, 03 Mar 2009 00:01:00 GMT no 14:50 Science Signaling, fibroblast growth factor receptor, FGFR, glioblastoma, kinase, kinetics, autophosphorylation http://podcasts.aaas.org/science_signaling/ScienceSignaling_090217.mp3 The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. Science Signaling The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090217.mp3 Tue, 17 Feb 2009 00:01:00 GMT no 15:21 Science Signaling, lymphocyte, osmotic stress, hyperosmolarity, guanine nucleotide exchange factor, Brx, NFAT5, spleen http://podcasts.aaas.org/science_signaling/ScienceSignaling_090203.mp3 Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. Science Signaling Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090203.mp3 Tue, 03 Feb 2009 00:01:00 GMT no 9:54 Science Signaling, mTOR, prostate cancer, rapamycin, TORC, cell growth, kinase inhibitor http://podcasts.aaas.org/science_signaling/ScienceSignaling_090127.mp3 Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Science Signaling Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090127.mp3 Tue, 27 Jan 2009 00:01:00 GMT no 9:50 Science Signaling, adipocyte, insulin, leptin, bone, fat, sympathetic nervous system, epinephrine, hormone, osteoblast, islet cells, pancreas, osteocalcin, adrenaline http://podcasts.aaas.org/science_signaling/ScienceSignaling_090113.mp3 The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. Science Signaling The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090113.mp3 Tue, 13 Jan 2009 00:01:00 GMT no 13:16 Science Signaling, hypoxia, HIF-1α, compartmentalization, oxygen, mAKAP, nuclear envelope, scaffold protein http://podcasts.aaas.org/science_signaling/ScienceSignaling_081216.mp3 Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. Science Signaling Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081216.mp3 Tue, 16 Dec 2008 00:01:00 GMT no 9:40 Science Signaling, CD3ε, T cell receptor, TCR, immunology, major histocompatibilty complex, MHC, antigen, immunoreceptor tyrosine-based activation motif, ITAM http://podcasts.aaas.org/science_signaling/ScienceSignaling_081202.mp3 Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. Science Signaling Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081202.mp3 Tue, 02 Dec 2008 00:01:00 GMT no 12:30 Science Signaling, signal transduction, ultraviolet light, UVB, radiation, DNA damage, apoptosis, JNK, ROCK1, Rho, kinase, JIP-3, MAPK http://podcasts.aaas.org/science_signaling/ScienceSignaling_081125.mp3 Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. Science Signaling Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081125.mp3 Tue, 25 Nov 2008 00:01:00 GMT no 11:03 Science Signaling, signal transduction, inflammation, immune system, immunity, secretase, protease, proteolytic processing, LRP, liproprotein receptor, LDL receptor, lipopolysaccharide, LPS http://podcasts.aaas.org/science_signaling/ScienceSignaling_081111.mp3 Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. Science Signaling Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081111.mp3 Tue, 11 Nov 2008 00:01:00 GMT no 10:35 Science Signaling, signal transduction, genetic screen, Wnt, Wingless, RNAi, proteomics, colon cancer http://podcasts.aaas.org/science_signaling/ScienceSignaling_081028.mp3 Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players. Science Signaling Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players. Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players.. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081028.mp3 Tue, 28 Oct 2008 00:01:00 GMT no 8:57 Science Signaling, signal transduction, NetPhorest, NetworKIN, kinome, database, phorphorylation, kinase, phosphatase, network http://podcasts.aaas.org/science_signaling/ScienceSignaling_081007.mp3 The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. Science Signaling The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081007.mp3 Tue, 07 Oct 2008 00:01:00 GMT no 7:07 Science Signaling, signal transduction, microbiology, periodontitis, gingivitis, virulence, fimbriae, CXCR4, TLR, bacteria http://podcasts.aaas.org/science_signaling/ScienceSignaling_080923.mp3 Bacteria secrete factors that regulate genes that contribute to virulence. Science Signaling Bacteria secrete factors that regulate genes that contribute to virulence. Bacteria secrete factors that regulate genes that contribute to virulence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080923.mp3 Tue, 23 Sep 2008 00:01:00 GMT no 12:16 Science Signaling, signal transduction, microbiology, cholera, virulence, flagellum, secretion, tuberculosis, transcription, gene expression http://podcasts.aaas.org/science_signaling/ScienceSignaling_080805.mp3 Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. Science Signaling Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080805.mp3 Tue, 05 Aug 2008 00:01:00 GMT no 11:00 Science Signaling, signal transduction, nociception, ion channels, anesthetic, anesthesia, peripheral nervous system, pain http://podcasts.aaas.org/science_signaling/ScienceSignaling_080715.mp3 Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. Science Signaling Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080715.mp3 Tue, 15 Jul 2008 00:01:00 GMT no 10:54 Science Signaling, signal transduction, macrophage, immunity, cancer, bacterial infection, NF-kappaB, IKKbeta http://podcasts.aaas.org/science_signaling/ScienceSignaling_080617.mp3 Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. Science Signaling Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080617.mp3 Tue, 17 Jun 2008 00:01:00 GMT no 8:08 Science Signaling, signal transduction, neurobiology, glioma, brain, cancer, microvesicle, epidermal growth factor receptor, EGFR http://podcasts.aaas.org/science_signaling/ScienceSignaling_080506.mp3 Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Science Signaling Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Some glial cells can generate action potentials and are hypersensitive to ischemic injury. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080506.mp3 Tue, 06 May 2008 00:01:00 GMT no 5:42 Science Signaling, signal transduction, neurobiology, neuroscience, glia, neuron, action potential, ischemia, myelin, NG2, oligodendrocyte http://podcasts.aaas.org/science_signaling/ScienceSignaling_080408.mp3 Mutations in the IGF-1 receptor are associated with longer life span in humans. Science Signaling Mutations in the IGF-1 receptor are associated with longer life span in humans. Mutations in the IGF-1 receptor are associated with longer life span in humans. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080408.mp3 Tue, 08 Apr 2008 00:01:00 GMT no 7:11 Science Signaling, signal transduction, life span, aging, longevity, growth hormone, genetics, insulin-like growth factor 1, centenarian http://podcasts.aaas.org/science_signaling/ScienceSignaling_080222.mp3 Glucose may stimulate the formation of fat tissue in muscle. Science Signaling Glucose may stimulate the formation of fat tissue in muscle. Glucose may stimulate the formation of fat tissue in muscle. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080222.mp3 Thu, 21 Feb 2008 23:59:00 GMT no 7:12 Science Signaling, signal transduction, stem cells, fat, adipose, diabetes, metabolism, glucose, cultured cells, cell biology http://podcasts.aaas.org/science_signaling/ScienceSignaling_080118.mp3 Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. Science Signaling Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080118.mp3 Thu, 17 Jan 2008 23:59:00 GMT no 9:13 Science Signaling, signal transduction, neuroscience, GABA, critical period, brain, plasticity, polysialic acid, inhibitory neuron, development, mouse