http://stke.sciencemag.org/rss/podcast.xml Periodic audiocasts from Science Signaling, the signal transduction knowledge environment. en-us Tue, 14 Feb 2012 00:01:00 GMT © 2012 American Association for the Advancement of Science swills@aaas.org http://www.sciencemag.org/icons/pic.sub.science-stke.gif http://stke.sciencemag.org/rss/podcast.xml 95 62 Science Signaling Podcast Science Signaling Periodic audiocasts from Science Signaling, the signal transduction knowledge environment. Nancy Gough ngough@aaas.org no http://podcasts.aaas.org/science_signaling/ScienceSignaling_120214.mp3 The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization. Science Signaling The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization. The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120214.mp3 Tue, 14 Feb 2012 00:01:00 GMT no 15:28 Science Signaling, actin depolymerizing factor, Candida albicans, cofilin, immunocompromise, immunosuppression, innate immunity, lung infection, macrophage, pathogen, PGE2, phagocytosis, prostaglandin E2, PTEN http://podcasts.aaas.org/science_signaling/ScienceSignaling_120207.mp3 Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. Science Signaling Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120207.mp3 Tue, 07 Feb 2012 00:01:00 GMT no 15:03 Science Signaling, breast cancer, casein kinase 2, CK2, migration, proliferation, second messenger, zinc transporter, ZIP7 http://podcasts.aaas.org/science_signaling/ScienceSignaling_120131.mp3 Signaling through PAS kinases bypasses the pro-growth requirement of Tor2 in yeast. Science Signaling Signaling through PAS kinases bypasses the pro-growth requirement of Tor2 in yeast. Signaling through PAS kinases bypasses the pro-growth requirement of Tor2 in yeast. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120131.mp3 Tue, 31 Jan 2012 00:01:00 GMT no 16:38 Science Signaling, cell wall synthesis, genetic screen, growth, overexpression, PAS kinase, Psk1, Psk2, Rho1, stress, target of rapamycin, TOR, Tor2, Ugp1, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_120110.mp3 Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies. Science Signaling Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies. Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies. http://podcasts.aaas.org/science_signaling/ScienceSignaling_120110.mp3 Tue, 10 Jan 2012 00:01:00 GMT no 13:48 Science Signaling, apoptosis, beta-catenin, BRAF, cell death, chemotherapy, ERK, extracellular signal-regulated kinase, kinase inhibitor, MAP kinase, mitogen-activated protein kinase, melanocyte, melanoma, metastasis, neural crest, skin cancer, Wnt http://podcasts.aaas.org/science_signaling/ScienceSignaling_11220.mp3 Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor. Science Signaling Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor. Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111220.mp3 Tue, 20 Dec 2011 00:01:00 GMT no 16:25 Science Signaling, autoimmunity, calcium, cancer, conventional T cell, regulatory T cell, suppression, T cell receptor, Tcon, TCR, Treg http://podcasts.aaas.org/science_signaling/ScienceSignaling_111129.mp3 Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling. Science Signaling Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling. Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111129.mp3 Tue, 29 Nov 2011 00:01:00 GMT no 15:05 Science Signaling, calcium-sensing receptor, CaSR, endocytosis, exocytosis, G protein-coupled receptor, GPCR, parathyroid hormone, trafficking http://podcasts.aaas.org/science_signaling/ScienceSignaling_111108.mp3 The vacuolar ATPase is required for amino acid-mediated activation of mTORC1. Science Signaling The vacuolar ATPase is required for amino acid-mediated activation of mTORC1. The vacuolar ATPase is required for amino acid-mediated activation of mTORC1. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111108.mp3 Tue, 08 Nov 2011 00:01:00 GMT no 10:40 Science Signaling, amino acid sensing, GTPase, lysosome, mammalian target of rapamycin complex 1, mTORC1, proton pump, Rag, Ragulator, Rheb, vacuolar ATPase, V-ATPase http://podcasts.aaas.org/science_signaling/ScienceSignaling_111101.mp3 An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor. Science Signaling An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor. An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111101.mp3 Tue, 01 Nov 2011 00:01:00 GMT no 15:14 Science Signaling, Act1, chemokine, cytokine, IL-17, IL-25, inflammation, Interleukin-17, Interleukin-25, peptide, T cell http://podcasts.aaas.org/science_signaling/ScienceSignaling_111025.mp3 A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila. Science Signaling A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila. A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111025.mp3 Tue, 25 Oct 2011 00:01:00 GMT no 16:23 Science Signaling, Drosophila melanogaster, ERK, extracellular signal-regulated kinase, fruit fly, MAPK, MAP kinase, mass spectrometry, mitogen-activated protein kinase, proteomics, Ras, RNAi, RNA interference, screen http://podcasts.aaas.org/science_signaling/ScienceSignaling_111011.mp3 Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling. Science Signaling Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling. Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111011.mp3 Tue, 11 Oct 2011 00:01:00 GMT no 12:32 Science Signaling, antagonism, BMP, bone morphogenetic protein, Decapentaplegic, Dpp, development, glycogen synthase kinase, GSK-3, Mad, morphogen gradient, Mothers against Dpp, phosphorylation, Wg, Wingless, Wnt http://podcasts.aaas.org/science_signaling/ScienceSignaling_111004.mp3 By working together, cells can overcome the loss of information as it flows through a signaling network. Science Signaling By working together, cells can overcome the loss of information as it flows through a signaling network. By working together, cells can overcome the loss of information as it flows through a signaling network. http://podcasts.aaas.org/science_signaling/ScienceSignaling_111004.mp3 Tue, 04 Oct 2011 00:01:00 GMT no 15:50 Science Signaling, biochemical network, bottleneck, information flow, modeling, systems biology, TNF, tumor necrosis factor alpha http://podcasts.aaas.org/science_signaling/ScienceSignaling_110920.mp3 Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells. Science Signaling Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells. Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110920.mp3 Tue, 20 Sep 2011 00:01:00 GMT no 13:43 Science Signaling, breast cancer, chemokine, CXCR4, fasudil, G protein, metastasis, Rho, SDF-1 http://podcasts.aaas.org/science_signaling/ScienceSignaling_110913.mp3 Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade. Science Signaling Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade. Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110913.mp3 Tue, 13 Sep 2011 00:01:00 GMT no 15:49 Science Signaling, differentiation, EGF, epidermal growth factor, ERK, extracellular signal-regulated kinase, methyltransferase, nerve growth factor, NGF, PC12 cells, PRMT5, proliferation, RAF, RAS http://podcasts.aaas.org/science_signaling/ScienceSignaling_110906.mp3 Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation. Science Signaling Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation. Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110906.mp3 Tue, 06 Sep 2011 00:01:00 GMT no 16:03 Science Signaling, adhesion, CD11b/CD18, inflammation, inflammatory disease, injury, integrin, leukocyte, migration http://podcasts.aaas.org/science_signaling/ScienceSignaling_110823.mp3 β2 subunit-containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus. Science Signaling β2 subunit-containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus. β2 subunit-containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110823.mp3 Tue, 23 Aug 2011 00:01:00 GMT no 10:54 Science Signaling, Alzheimer’s disease, attentional focus, cholinergic signaling, cognition, dementia, medial prefrontal cortex, nicotinic acetylcholine receptor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110809.mp3 Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide. Science Signaling Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide. Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110809.mp3 Tue, 09 Aug 2011 00:01:00 GMT no 12:53 Science Signaling, endocytosis, morphine, Mu-type opioid receptor, opiate, partial agonist, phosphorylation http://podcasts.aaas.org/science_signaling/ScienceSignaling_110726.mp3 A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation. Science Signaling A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation. A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110726.mp3 Tue, 26 Jul 2011 00:01:00 GMT no 16:30 Science Signaling, cancer, chemotherapy, Cdk5, cyclin-dependent kinase, invadopodia, invasion, metastasis, paclitaxel, Taxol http://podcasts.aaas.org/science_signaling/ScienceSignaling_110705.mp3 The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling. Science Signaling The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling. The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110705.mp3 Tue, 05 Jul 2011 00:01:00 GMT no 10:49 Science Signaling, asthma, chloroquine, combination therapy, dexamethasone, glucocorticoid receptor, inflammation, inflammatory arthritis http://podcasts.aaas.org/science_signaling/ScienceSignaling_110628.mp3 Two studies shed light on cell cycle-dependent protein phosphorylation during mitosis in yeast. Science Signaling Two studies shed light on cell cycle-dependent protein phosphorylation during mitosis in yeast. Two studies shed light on cell cycle-dependent protein phosphorylation during mitosis in yeast. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110628.mp3 Tue, 28 Jun 2011 00:01:00 GMT no 19:27 Science Signaling, Aurora, cell cycle, centrosome, kinase, mitosis, phosphoproteome, phosphoproteomics, protein phosphorylation, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_110614.mp3 Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes. Science Signaling Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes. Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110614.mp3 Tue, 14 Jun 2011 00:01:00 GMT no 13:03 Science Signaling, crystal structure, F-actin, filamentous, G-actin, MRTF-A, nucleocytoplasmic shuttling, RPEL domain, structural biology, transcriptional coactivator, transcription factor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110524.mp3 Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap. Science Signaling Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap. Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110524.mp3 Tue, 24 May 2011 00:01:00 GMT no 16:24 Science Signaling, alpha-catenin, alphaE-catenin, beta-catenin, cancer, cell proliferation, development, growth control, heart, Hippo, keratinocyte, mouse, organ size, skin cancer, squamous call carcinoma, Wnt, Yap1 http://podcasts.aaas.org/science_signaling/ScienceSignaling_110503.mp3 Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation. Science Signaling Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation. Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110503.mp3 Tue, 03 May 2011 00:01:00 GMT no 15:01 Science Signaling, adjuvant, endotoxin, immune response, inflammasome, inflammation, interleukin-1, IL-1, lipopolysaccharide, LPS, monophosphoryl lipid A, MLA, MyD88, Toll-like receptor 4, TLR4, TRIF, vaccine http://podcasts.aaas.org/science_signaling/ScienceSignaling_110426.mp3 A growth factor that antagonizes signaling by tumor necrosis factor α relieves symptoms of inflammatory arthritis. Science Signaling A growth factor that antagonizes signaling by tumor necrosis factor α relieves symptoms of inflammatory arthritis. A growth factor that antagonizes signaling by tumor necrosis factor α relieves symptoms of inflammatory arthritis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110426.mp3 Tue, 26 Apr 2011 00:01:00 GMT no 11:58 Science Signaling, cytokine, growth factor, inflammation, inflammatory arthritis, progranulin, rheumatoid arthritis, tumor necrosis factor alpha, tumor necrosis factor receptor, TNFalpha, TNFR, TNF inhibitor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110405.mp3 The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors. Science Signaling The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors. The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110405.mp3 Tue, 05 Apr 2011 00:01:00 GMT no 14:32 Science Signaling, autoimmunity, autoreactivity, immune tolerance, lipid draft, major histocompatibility complex class I, microdomain, nanodomain, MHC class I, natural killer cell, NK cell, plasma membrane, receptor, self-tolerance http://podcasts.aaas.org/science_signaling/ScienceSignaling_110329.mp3 Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. Science Signaling Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110329.mp3 Tue, 29 Mar 2011 00:01:00 GMT no 12:39 Science Signaling, B-ALL, B cell acute lymphoblastic leukemia, Bcr-Abl, cancer, chronic myelogenous leukemia, CML, network, phosphoproteomics, Src family kinase, tyrosine kinase inhibitor http://podcasts.aaas.org/science_signaling/ScienceSignaling_110315.mp3 A protein required for light sensation also plays a role in thermosensing in the fruit fly. Science Signaling A protein required for light sensation also plays a role in thermosensing in the fruit fly. A protein required for light sensation also plays a role in thermosensing in the fruit fly. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110315.mp3 Tue, 15 Mar 2011 00:01:00 GMT no 13:58 Science Signaling, Drosophila melanogaster, fruit fly, light, photoreception, rhodopsin, temperature, thermosensation, thermotaxis, transient receptor potential channel, TRP http://podcasts.aaas.org/science_signaling/ScienceSignaling_110308.mp3 Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. Science Signaling Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110308.mp3 Tue, 08 Mar 2011 00:01:00 GMT no 14:59 Science Signaling, Decapentaplegic, disc, Dpp, Drosophila, fly, gradient, mathematical modeling, morphogen, proliferation, wing http://podcasts.aaas.org/science_signaling/ScienceSignaling_110222.mp3 A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli. Science Signaling A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli. A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110222.mp3 Tue, 22 Feb 2011 00:01:00 GMT no 15:03 Science Signaling, antiviral response, innate immunity, interferon response element, interferon regulatory factor, IRE, IRF, NF-kappaB, nuclear factor kappaB http://podcasts.aaas.org/science_signaling/ScienceSignaling_110125.mp3 Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. Science Signaling Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110125.mp3 Tue, 25 Jan 2011 00:01:00 GMT no 12:43 Science Signaling, fasudil, obesity, hypothalamus, inflammation, insulin resistance, mechanical stretch, mechanotransduction, metabolism, osmolarity, Rho, Rho-kinase, vasopressin http://podcasts.aaas.org/science_signaling/ScienceSignaling_110104.mp3 Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. Science Signaling Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_110104.mp3 Tue, 04 Jan 2011 00:01:00 GMT no 13:25 Science Signaling, experiments, research articles, review http://podcasts.aaas.org/science_signaling/ScienceSignaling_101221.mp3 Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast. Science Signaling Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast. Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101221.mp3 Tue, 21 Dec 2010 00:01:00 GMT no 14:01 Science Signaling, kinase, network analysis, phosphatase, phosphoproteome, proteome, systems biology, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_101207.mp3 Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins. Science Signaling Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins. Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101207.mp3 Tue, 07 Dec 2010 00:01:00 GMT no 15:06 Science Signaling, 19S, 20S, 26S, catalytic particle, cell stress, degradation, hydrogen peroxide, oxidation, proteasome, protein damage, regulatory particle, ubiquitin, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_101123.mp3 Targeting interactions between HLA-I and the integrin beta4 subunit is a potential strategy for preventing transplant rejection. Science Signaling Targeting interactions between HLA-I and the integrin beta4 subunit is a potential strategy for preventing transplant rejection. Targeting interactions between HLA-I and the integrin beta4 subunit is a potential strategy for preventing transplant rejection. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101123.mp3 Tue, 23 Nov 2010 00:01:00 GMT no 12:10 Science Signaling, angiogenesis, atherosclerosis, endothelial cell, HLA, human leukocyte antigen, integrin, organ transplant, rejection, vasculopathy http://podcasts.aaas.org/science_signaling/ScienceSignaling_101109.mp3 A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease. Science Signaling A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease. A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101109.mp3 Tue, 09 Nov 2010 00:01:00 GMT no 12:16 Science Signaling, action potential, ATP, axon, glia, neuron, nonvesicular, membrane stretch, swelling, synapse, volume-activated anion channel http://podcasts.aaas.org/science_signaling/ScienceSignaling_101026.mp3 Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy. Science Signaling Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy. Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101026.mp3 Tue, 26 Oct 2010 00:01:00 GMT no 9:51 Science Signaling, angiogenesis, ARAP3, blood vessel, PI3 kinase, vasculature, vascular system, vasculogenesis http://podcasts.aaas.org/science_signaling/ScienceSignaling_101005.mp3 Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke. Science Signaling Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke. Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke. http://podcasts.aaas.org/science_signaling/ScienceSignaling_101005.mp3 Tue, 05 Oct 2010 00:01:00 GMT no 11:29 Science Signaling, apolipoprotein-E, ApoE, ApoE receptor, blood-brain barrier, drug delivery, ischemia, permeability, stroke http://podcasts.aaas.org/science_signaling/ScienceSignaling_100824.mp3 A phosphoprotemic approach identifies potential targets for developing combination therapies to treat cancer. Science Signaling A phosphoprotemic approach identifies potential targets for developing combination therapies to treat cancer. A phosphoprotemic approach identifies potential targets for developing combination therapies to treat cancer. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100824.mp3 Tue, 24 Aug 2010 00:01:00 GMT no 11:42 Science Signaling, cancer, drug targets, proteomics, receptor tyrosine kinase, RTK, screen, yeast http://podcasts.aaas.org/science_signaling/ScienceSignaling_100803.mp3 A virally-encoded G protein-coupled receptor promotes cellular proliferation and vascularization. Science Signaling A virally-encoded G protein-coupled receptor promotes cellular proliferation and vascularization. A virally-encoded G protein-coupled receptor promotes cellular proliferation and vascularization. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100803.mp3 Tue, 03 Aug 2010 00:01:00 GMT no 6:47 Science Signaling, cancer, cell proliferation, chemokine, G protein-coupled receptor, GPCR, HCMV, human cytomegalovirus, tumor, US28, vascularization http://podcasts.aaas.org/science_signaling/ScienceSignaling_100720.mp3 Network redundancies lend robustness to the neuronal injury response. Science Signaling Network redundancies lend robustness to the neuronal injury response. Network redundancies lend robustness to the neuronal injury response. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100720.mp3 Tue, 20 Jul 2010 00:01:00 GMT no 10:07 Science Signaling, growth, injury, network, neurite, neuron, phosphoproteomics, regeneration, repair, retrograde transport http://podcasts.aaas.org/science_signaling/ScienceSignaling_100706.mp3 Lateral inhibition in proneuronal clusters in the fruit fly relies on competition between cis and trans Notch signaling. Science Signaling Lateral inhibition in proneuronal clusters in the fruit fly relies on competition between cis and trans Notch signaling. Lateral inhibition in proneuronal clusters in the fruit fly relies on competition between cis and trans Notch signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100706.mp3 Tue, 6 Jul 2010 00:01:00 GMT no 13:53 Science Signaling, bristle, computational biology, Delta, Drosophila melanogaster, fruit fly, lateral inhibition, mathematical modeling, Notch, proneural cluster, sensory organ precursor, SOP http://podcasts.aaas.org/science_signaling/ScienceSignaling_100629.mp3 Analysis of TOR signaling pathway evolution may shed light on the early divergence of eukaryotic lineages. Science Signaling Analysis of TOR signaling pathway evolution may shed light on the early divergence of eukaryotic lineages. Analysis of TOR signaling pathway evolution may shed light on the early divergence of eukaryotic lineages. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100629.mp3 Tue, 29 Jun 2010 00:01:00 GMT no 15:17 Science Signaling, bikont, Amoebozoa, Archaeplastida, Chromalveolata, eukaryote, evolution, Excavata, Opisthokonta, target of rapamycin, TOR pathway, unikont http://podcasts.aaas.org/science_signaling/ScienceSignaling_100608.mp3 Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating beta-arrestin-dependent signaling. Science Signaling Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating beta-arrestin-dependent signaling. Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating beta-arrestin-dependent signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100608.mp3 Tue, 8 Jun 2010 00:01:00 GMT no 19:32 Science Signaling, angiotensin, AT1R, beta-arrestin, blood pressure, cell survival, G protein-coupled receptor, GPCR, hypertension, mechanical stress, mechanotransduction http://podcasts.aaas.org/science_signaling/ScienceSignaling_100525.mp3 The balance between WNT and FGF signaling influences the mode of bone formation in the skull. Science Signaling The balance between WNT and FGF signaling influences the mode of bone formation in the skull. The balance between WNT and FGF signaling influences the mode of bone formation in the skull. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100525.mp3 Tue, 25 May 2010 00:01:00 GMT no 10:13 Science Signaling, bone, chondrocyte, cranium, craniosynostosis, endochondral bone, FGF, intramembranous ossification, skull suture, WNT http://podcasts.aaas.org/science_signaling/ScienceSignaling_100511.mp3 Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis. Science Signaling Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis. Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100511.mp3 Tue, 11 May 2010 00:01:00 GMT no 16:34 Science Signaling, anchor cell invasion, Caenorhabditis elegans, cell invasion, invadopodia, invasiveness, metastasis, nematode, vulva, worm http://podcasts.aaas.org/science_signaling/ScienceSignaling_100504.mp3 Ammonia induces autophagy, which may help cancer cells survive stressful conditions. Science Signaling Ammonia induces autophagy, which may help cancer cells survive stressful conditions. Ammonia induces autophagy, which may help cancer cells survive stressful conditions. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100504.mp3 Tue, 04 May 2010 00:01:00 GMT no 15:26 Science Signaling, ammonia, autophagy, cancer, glutaminolysis, metabolism, mTOR, starvation, tumor http://podcasts.aaas.org/science_signaling/ScienceSignaling_100420.mp3 Integrating interactome and genetics data allows researchers to predict adverse drug effects. Science Signaling Integrating interactome and genetics data allows researchers to predict adverse drug effects. Integrating interactome and genetics data allows researchers to predict adverse drug effects. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100420.mp3 Tue, 20 Apr 2010 00:01:00 GMT no 14:30 Science Signaling, adverse effects, cardiac arrhythmia, drug, ion channel, long QT syndrome, side effect, single nucleotide polymorphism, SNP http://podcasts.aaas.org/science_signaling/ScienceSignaling_100330.mp3 The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion. Science Signaling The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion. The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100330.mp3 Tue, 30 Mar 2010 00:01:00 GMT no 16:29 Science Signaling, adhesion, AMP kinase, LKB1, myosin phosphatase, NUAK, Peutz-Jeghers syndrome, phosphorylation, proliferation, tumor suppressor http://podcasts.aaas.org/science_signaling/ScienceSignaling_100316.mp3 Reduction of ankyrin-B activity impairs maximal insulin release and is a risk factor for diabetes. Science Signaling Reduction of ankyrin-B activity impairs maximal insulin release and is a risk factor for diabetes. Reduction of ankyrin-B activity impairs maximal insulin release and is a risk factor for diabetes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100316.mp3 Tue, 16 Mar 2010 00:01:00 GMT no 14:42 Science Signaling, acetylcholine, beta cells, cholinergic, glucose, insulin secretion, islet cells, pancreas, parasympathetic nervous system, vagus nerve http://podcasts.aaas.org/science_signaling/ScienceSignaling_100223.mp3 Dying cells release signals that stimulate cellular proliferation in regenerating tissues. Science Signaling Dying cells release signals that stimulate cellular proliferation in regenerating tissues. Dying cells release signals that stimulate cellular proliferation in regenerating tissues. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100223.mp3 Tue, 23 Feb 2010 00:01:00 GMT no 12:40 Science Signaling, apoptosis, proliferation, regeneration, wound healing http://podcasts.aaas.org/science_signaling/ScienceSignaling_100216.mp3 The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk. Science Signaling The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk. The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100216.mp3 Tue, 16 Feb 2010 00:01:00 GMT no 16:26 Science Signaling, atherosclerosis, complement, gingivitis, innate immunity, periodontitis, Porphyromonas gingivalis, Toll-like receptor 2 http://podcasts.aaas.org/science_signaling/ScienceSignaling_100202.mp3 A noncoding RNA competes with DNA for binding to the glucocorticoid receptor. Science Signaling A noncoding RNA competes with DNA for binding to the glucocorticoid receptor. A noncoding RNA competes with DNA for binding to the glucocorticoid receptor. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100202.mp3 Tue, 02 Feb 2010 00:01:00 GMT no 13:47 Science Signaling, DNA binding, glucocorticoid response element, GRE, hormone, noncoding RNA, nuclear receptor, transcription factor http://podcasts.aaas.org/science_signaling/ScienceSignaling_100126.mp3 A single amino acid substitution in a viral protein is sufficient to attenuate rabies virulence. Science Signaling A single amino acid substitution in a viral protein is sufficient to attenuate rabies virulence. A single amino acid substitution in a viral protein is sufficient to attenuate rabies virulence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100126.mp3 Tue, 26 Jan 2010 00:01:00 GMT no 12:36 Science Signaling, apoptosis, attenuation, cell death, neuron, rabies, virulence, virus http://podcasts.aaas.org/science_signaling/ScienceSignaling_100105.mp3 Chief Scientific Editor Michael Yaffe reviews the year in Science Signaling. Science Signaling Chief Scientific Editor Michael Yaffe reviews the year in Science Signaling. Chief Scientific Editor Michael Yaffe reviews the year in Science Signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_100105.mp3 Tue, 05 Jan 2010 00:01:00 GMT no 12:20 Science Signaling, breakthrough, experiments, research articles, technologies http://podcasts.aaas.org/science_signaling/ScienceSignaling_091215.mp3 Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling. Science Signaling Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling. Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091215.mp3 Tue, 15 Dec 2009 00:01:00 GMT no 16:59 Science Signaling, epidermal growth factor receptor (EGFR), glioblastoma, lapatinib, lipid biosynthesis, sterol regulatory element-binding protein 1 (SREBP1) http://podcasts.aaas.org/science_signaling/ScienceSignaling_091201.mp3 Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue. Science Signaling Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue. Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091201.mp3 Tue, 01 Dec 2009 00:01:00 GMT no 14:17 Science Signaling, adipose tissue, brown fat, energy, lipids, preadipocyte, thermogenesis http://podcasts.aaas.org/science_signaling/ScienceSignaling_091124.mp3 Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change. Science Signaling Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change. Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091124.mp3 Tue, 24 Nov 2009 00:01:00 GMT no 19:32 Science Signaling, evolution, modularity, protein domain, proteomics http://podcasts.aaas.org/science_signaling/ScienceSignaling_091110.mp3 The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. Science Signaling The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091110.mp3 Tue, 10 Nov 2009 00:01:00 GMT no 19:01 Science Signaling, gasotransmitter, hydrogen sulfide, posttranslational modification, sulfhydration, vasorelaxant http://podcasts.aaas.org/science_signaling/ScienceSignaling_091027.mp3 Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. Science Signaling Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091027.mp3 Tue, 27 Oct 2009 00:01:00 GMT no 13:37 Science Signaling, aging, cell proliferation, mitogen-activated protein kinase kinase 4, Mek4, MKK4, microRNA, replicative senescence http://podcasts.aaas.org/science_signaling/ScienceSignaling_091013.mp3 Distinct Src kinases regulate the differentiation of embryonic stem cells. Science Signaling Distinct Src kinases regulate the differentiation of embryonic stem cells. Distinct Src kinases regulate the differentiation of embryonic stem cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091013.mp3 Tue, 13 Oct 2009 00:01:00 GMT no 15:32 Science Signaling, c-Src, c-Yes, development, differentiation, embryonic stem cell, primitive ectoderm, Src kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_091006.mp3 Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. Science Signaling Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091006.mp3 Tue, 06 Oct 2009 00:01:00 GMT no 15:46 Science Signaling, cell proliferation, Drosophila, fruit fly, gradient, morphogen, patterning, Wingless http://podcasts.aaas.org/science_signaling/ScienceSignaling_090908.mp3 Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. Science Signaling Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090908.mp3 Tue, 08 Sep 2009 00:01:00 GMT no 15:00 Science Signaling, evolution, multicellular, mutagenesis, PDZ domain, protein-protein interaction network http://podcasts.aaas.org/science_signaling/ScienceSignaling_090818.mp3 Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. Science Signaling Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090818.mp3 Tue, 18 Aug 2009 00:01:00 GMT no 19:27 Science Signaling, phosphoproteomics, phosphorylation, protein-protein interaction, proteomics, systems biology, T cell activation, T cell receptor, TCR http://podcasts.aaas.org/science_signaling/ScienceSignaling_090728.mp3 Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.. Science Signaling Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.. Science Signaling's Chief Scientific Editor discusses complexity in signaling networks. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090728.mp3 Tue, 28 Jul 2009 00:01:00 GMT no 12:43 Science Signaling, complexity, dynamics, interactome, network, protein-protein interaction http://podcasts.aaas.org/science_signaling/ScienceSignaling_090721.mp3 A small G protein may limit the toxicity of mutant huntingtin to the brain. Science Signaling A small G protein may limit the toxicity of mutant huntingtin to the brain. A small G protein may limit the toxicity of mutant huntingtin to the brain. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090721.mp3 Tue, 21 Jul 2009 00:01:00 GMT no 5:53 Science Signaling, Alzheimer's disease, huntingtin, Huntington's disease, neurodegeneration, Parkinson's disease http://podcasts.aaas.org/science_signaling/ScienceSignaling_090630.mp3 Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Science Signaling Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090630.mp3 Tue, 30 Jun 2009 00:01:00 GMT no 14:13 Science Signaling, cancer, drug target, EGFR, ErbB, mathematical modeling, systems biology http://podcasts.aaas.org/science_signaling/ScienceSignaling_090623.mp3 A microfluidic device enables high-throughput analysis of signaling in individual cells. Science Signaling A microfluidic device enables high-throughput analysis of signaling in individual cells. A microfluidic device enables high-throughput analysis of signaling in individual cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090623.mp3 Tue, 23 Jun 2009 00:01:00 GMT no 17:27 Science Signaling, engineering, microfabrication, microfluidic device, protocol http://podcasts.aaas.org/science_signaling/ScienceSignaling_090609.mp3 Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. Science Signaling Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090609.mp3 Tue, 09 Jun 2009 00:01:00 GMT no 24:14 Science Signaling, allergy, degranulation, mast cell, phosphatidylinositol. phosphoinositide, PIP2, PIP3, PI3 kinase, second messenger http://podcasts.aaas.org/science_signaling/ScienceSignaling_090519.mp3 TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. Science Signaling TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090519.mp3 Tue, 19 May 2009 00:01:00 GMT no 14:26 Science Signaling, TRP channel, TRPM1, melanin, melanocyte, melanoma, melastatin, pigment http://podcasts.aaas.org/science_signaling/ScienceSignaling_090421.mp3 Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. Science Signaling Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090421.mp3 Tue, 21 Apr 2009 00:01:00 GMT no 22:55 Science Signaling, mammalian target of rapamycin, mTOR, mTORC1, mTORC2, cancer, immunology, inhibitors, kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_090407.mp3 The sets of kinases required by different cancer cell lines are highly divergent. Science Signaling The sets of kinases required by different cancer cell lines are highly divergent. The sets of kinases required by different cancer cell lines are highly divergent. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090407.mp3 Tue, 07 Apr 2009 00:01:00 GMT no 11:59 Science Signaling, kinome, kinase, cancer, screen http://podcasts.aaas.org/science_signaling/ScienceSignaling_090324.mp3 The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. Science Signaling The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090324.mp3 Tue, 24 Mar 2009 00:01:00 GMT no 14:10 Science Signaling, Mycobacterium tuberculosis, forkhead-associated domain, FHA, phosphorylation, phosphothreonine, kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_090303.mp3 Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. Science Signaling Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090303.mp3 Tue, 03 Mar 2009 00:01:00 GMT no 14:50 Science Signaling, fibroblast growth factor receptor, FGFR, glioblastoma, kinase, kinetics, autophosphorylation http://podcasts.aaas.org/science_signaling/ScienceSignaling_090217.mp3 The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. Science Signaling The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090217.mp3 Tue, 17 Feb 2009 00:01:00 GMT no 15:21 Science Signaling, lymphocyte, osmotic stress, hyperosmolarity, guanine nucleotide exchange factor, Brx, NFAT5, spleen http://podcasts.aaas.org/science_signaling/ScienceSignaling_090203.mp3 Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. Science Signaling Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090203.mp3 Tue, 03 Feb 2009 00:01:00 GMT no 9:54 Science Signaling, mTOR, prostate cancer, rapamycin, TORC, cell growth, kinase inhibitor http://podcasts.aaas.org/science_signaling/ScienceSignaling_090127.mp3 Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Science Signaling Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090127.mp3 Tue, 27 Jan 2009 00:01:00 GMT no 9:50 Science Signaling, adipocyte, insulin, leptin, bone, fat, sympathetic nervous system, epinephrine, hormone, osteoblast, islet cells, pancreas, osteocalcin, adrenaline http://podcasts.aaas.org/science_signaling/ScienceSignaling_090113.mp3 The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. Science Signaling The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090113.mp3 Tue, 13 Jan 2009 00:01:00 GMT no 13:16 Science Signaling, hypoxia, HIF-1α, compartmentalization, oxygen, mAKAP, nuclear envelope, scaffold protein http://podcasts.aaas.org/science_signaling/ScienceSignaling_081216.mp3 Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. Science Signaling Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081216.mp3 Tue, 16 Dec 2008 00:01:00 GMT no 9:40 Science Signaling, CD3ε, T cell receptor, TCR, immunology, major histocompatibilty complex, MHC, antigen, immunoreceptor tyrosine-based activation motif, ITAM http://podcasts.aaas.org/science_signaling/ScienceSignaling_081202.mp3 Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. Science Signaling Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081202.mp3 Tue, 02 Dec 2008 00:01:00 GMT no 12:30 Science Signaling, signal transduction, ultraviolet light, UVB, radiation, DNA damage, apoptosis, JNK, ROCK1, Rho, kinase, JIP-3, MAPK http://podcasts.aaas.org/science_signaling/ScienceSignaling_081125.mp3 Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. Science Signaling Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081125.mp3 Tue, 25 Nov 2008 00:01:00 GMT no 11:03 Science Signaling, signal transduction, inflammation, immune system, immunity, secretase, protease, proteolytic processing, LRP, liproprotein receptor, LDL receptor, lipopolysaccharide, LPS http://podcasts.aaas.org/science_signaling/ScienceSignaling_081111.mp3 Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. Science Signaling Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081111.mp3 Tue, 11 Nov 2008 00:01:00 GMT no 10:35 Science Signaling, signal transduction, genetic screen, Wnt, Wingless, RNAi, proteomics, colon cancer http://podcasts.aaas.org/science_signaling/ScienceSignaling_081028.mp3 Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players. Science Signaling Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players. Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players.. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081028.mp3 Tue, 28 Oct 2008 00:01:00 GMT no 8:57 Science Signaling, signal transduction, NetPhorest, NetworKIN, kinome, database, phorphorylation, kinase, phosphatase, network http://podcasts.aaas.org/science_signaling/ScienceSignaling_081007.mp3 The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. Science Signaling The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081007.mp3 Tue, 07 Oct 2008 00:01:00 GMT no 7:07 Science Signaling, signal transduction, microbiology, periodontitis, gingivitis, virulence, fimbriae, CXCR4, TLR, bacteria http://podcasts.aaas.org/science_signaling/ScienceSignaling_080923.mp3 Bacteria secrete factors that regulate genes that contribute to virulence. Science Signaling Bacteria secrete factors that regulate genes that contribute to virulence. Bacteria secrete factors that regulate genes that contribute to virulence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080923.mp3 Tue, 23 Sep 2008 00:01:00 GMT no 12:16 Science Signaling, signal transduction, microbiology, cholera, virulence, flagellum, secretion, tuberculosis, transcription, gene expression http://podcasts.aaas.org/science_signaling/ScienceSignaling_080805.mp3 Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. Science Signaling Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080805.mp3 Tue, 05 Aug 2008 00:01:00 GMT no 11:00 Science Signaling, signal transduction, nociception, ion channels, anesthetic, anesthesia, peripheral nervous system, pain http://podcasts.aaas.org/science_signaling/ScienceSignaling_080715.mp3 Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. Science Signaling Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080715.mp3 Tue, 15 Jul 2008 00:01:00 GMT no 10:54 Science Signaling, signal transduction, macrophage, immunity, cancer, bacterial infection, NF-kappaB, IKKbeta http://podcasts.aaas.org/science_signaling/ScienceSignaling_080617.mp3 Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. Science Signaling Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080617.mp3 Tue, 17 Jun 2008 00:01:00 GMT no 8:08 Science Signaling, signal transduction, neurobiology, glioma, brain, cancer, microvesicle, epidermal growth factor receptor, EGFR http://podcasts.aaas.org/science_signaling/ScienceSignaling_080506.mp3 Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Science Signaling Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Some glial cells can generate action potentials and are hypersensitive to ischemic injury. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080506.mp3 Tue, 06 May 2008 00:01:00 GMT no 5:42 Science Signaling, signal transduction, neurobiology, neuroscience, glia, neuron, action potential, ischemia, myelin, NG2, oligodendrocyte http://podcasts.aaas.org/science_signaling/ScienceSignaling_080408.mp3 Mutations in the IGF-1 receptor are associated with longer life span in humans. Science Signaling Mutations in the IGF-1 receptor are associated with longer life span in humans. Mutations in the IGF-1 receptor are associated with longer life span in humans. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080408.mp3 Tue, 08 Apr 2008 00:01:00 GMT no 7:11 Science Signaling, signal transduction, life span, aging, longevity, growth hormone, genetics, insulin-like growth factor 1, centenarian http://podcasts.aaas.org/science_signaling/ScienceSignaling_080222.mp3 Glucose may stimulate the formation of fat tissue in muscle. Science Signaling Glucose may stimulate the formation of fat tissue in muscle. Glucose may stimulate the formation of fat tissue in muscle. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080222.mp3 Thu, 21 Feb 2008 23:59:00 GMT no 7:12 Science Signaling, signal transduction, stem cells, fat, adipose, diabetes, metabolism, glucose, cultured cells, cell biology http://podcasts.aaas.org/science_signaling/ScienceSignaling_080118.mp3 Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. Science Signaling Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080118.mp3 Thu, 17 Jan 2008 23:59:00 GMT no 9:13 Science Signaling, signal transduction, neuroscience, GABA, critical period, brain, plasticity, polysialic acid, inhibitory neuron, development, mouse