http://stke.sciencemag.org/rss/podcast.xml Periodic audiocasts from Science Signaling, the signal transduction knowledge environment. en-us Tue, 10 Nov 2009 00:01:00 GMT © 2009 American Association for the Advancement of Science swills@aaas.org http://www.sciencemag.org/icons/pic.sub.science-stke.gif http://stke.sciencemag.org/rss/podcast.xml 95 62 Science Signaling Podcast Science Signaling Periodic audiocasts from Science Signaling, the signal transduction knowledge environment. Nancy Gough ngough@aaas.org no http://podcasts.aaas.org/science_signaling/ScienceSignaling_091110.mp3 The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. Science Signaling The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. The gasotransmitter hydrogen sulfide signals by sulfhydrating target proteins. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091110.mp3 Tue, 10 Nov 2009 00:01:00 GMT no 19:01 Science Signaling, gasotransmitter, hydrogen sulfide, posttranslational modification, sulfhydration, vasorelaxant http://podcasts.aaas.org/science_signaling/ScienceSignaling_091027.mp3 Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. Science Signaling Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091027.mp3 Tue, 27 Oct 2009 00:01:00 GMT no 13:37 Science Signaling, aging, cell proliferation, mitogen-activated protein kinase kinase 4, Mek4, MKK4, microRNA, replicative senescence http://podcasts.aaas.org/science_signaling/ScienceSignaling_091013.mp3 Distinct Src kinases regulate the differentiation of embryonic stem cells. Science Signaling Distinct Src kinases regulate the differentiation of embryonic stem cells. Distinct Src kinases regulate the differentiation of embryonic stem cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091013.mp3 Tue, 13 Oct 2009 00:01:00 GMT no 15:32 Science Signaling, c-Src, c-Yes, development, differentiation, embryonic stem cell, primitive ectoderm, Src kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_091006.mp3 Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. Science Signaling Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. http://podcasts.aaas.org/science_signaling/ScienceSignaling_091006.mp3 Tue, 06 Oct 2009 00:01:00 GMT no 15:46 Science Signaling, cell proliferation, Drosophila, fruit fly, gradient, morphogen, patterning, Wingless http://podcasts.aaas.org/science_signaling/ScienceSignaling_090908.mp3 Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. Science Signaling Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090908.mp3 Tue, 08 Sep 2009 00:01:00 GMT no 15:00 Science Signaling, evolution, multicellular, mutagenesis, PDZ domain, protein-protein interaction network http://podcasts.aaas.org/science_signaling/ScienceSignaling_090818.mp3 Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. Science Signaling Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. Serine-threonine phosphorylation events regulate protein-protein interactions downstream of T cell receptor activation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090818.mp3 Tue, 18 Aug 2009 00:01:00 GMT no 19:27 Science Signaling, phosphoproteomics, phosphorylation, protein-protein interaction, proteomics, systems biology, T cell activation, T cell receptor, TCR http://podcasts.aaas.org/science_signaling/ScienceSignaling_090728.mp3 Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.. Science Signaling Science Signaling's Chief Scientific Editor discusses complexity in signaling networks.. Science Signaling's Chief Scientific Editor discusses complexity in signaling networks. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090728.mp3 Tue, 28 Jul 2009 00:01:00 GMT no 12:43 Science Signaling, complexity, dynamics, interactome, network, protein-protein interaction http://podcasts.aaas.org/science_signaling/ScienceSignaling_090721.mp3 A small G protein may limit the toxicity of mutant huntingtin to the brain. Science Signaling A small G protein may limit the toxicity of mutant huntingtin to the brain. A small G protein may limit the toxicity of mutant huntingtin to the brain. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090721.mp3 Tue, 21 Jul 2009 00:01:00 GMT no 5:53 Science Signaling, Alzheimer's disease, huntingtin, Huntington's disease, neurodegeneration, Parkinson's disease http://podcasts.aaas.org/science_signaling/ScienceSignaling_090630.mp3 Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Science Signaling Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090630.mp3 Tue, 30 Jun 2009 00:01:00 GMT no 14:13 Science Signaling, cancer, drug target, EGFR, ErbB, mathematical modeling, systems biology http://podcasts.aaas.org/science_signaling/ScienceSignaling_090623.mp3 A microfluidic device enables high-throughput analysis of signaling in individual cells. Science Signaling A microfluidic device enables high-throughput analysis of signaling in individual cells. A microfluidic device enables high-throughput analysis of signaling in individual cells. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090623.mp3 Tue, 23 Jun 2009 00:01:00 GMT no 17:27 Science Signaling, engineering, microfabrication, microfluidic device, protocol http://podcasts.aaas.org/science_signaling/ScienceSignaling_090609.mp3 Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. Science Signaling Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090609.mp3 Tue, 09 Jun 2009 00:01:00 GMT no 24:14 Science Signaling, allergy, degranulation, mast cell, phosphatidylinositol. phosphoinositide, PIP2, PIP3, PI3 kinase, second messenger http://podcasts.aaas.org/science_signaling/ScienceSignaling_090519.mp3 TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. Science Signaling TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090519.mp3 Tue, 19 May 2009 00:01:00 GMT no 14:26 Science Signaling, TRP channel, TRPM1, melanin, melanocyte, melanoma, melastatin, pigment http://podcasts.aaas.org/science_signaling/ScienceSignaling_090421.mp3 Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. Science Signaling Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090421.mp3 Tue, 21 Apr 2009 00:01:00 GMT no 22:55 Science Signaling, mammalian target of rapamycin, mTOR, mTORC1, mTORC2, cancer, immunology, inhibitors, kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_090407.mp3 The sets of kinases required by different cancer cell lines are highly divergent. Science Signaling The sets of kinases required by different cancer cell lines are highly divergent. The sets of kinases required by different cancer cell lines are highly divergent. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090407.mp3 Tue, 07 Apr 2009 00:01:00 GMT no 11:59 Science Signaling, kinome, kinase, cancer, screen http://podcasts.aaas.org/science_signaling/ScienceSignaling_090324.mp3 The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. Science Signaling The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. The activity of a bacterial FHA domain-containing protein is regulated intramolecularly. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090324.mp3 Tue, 24 Mar 2009 00:01:00 GMT no 14:10 Science Signaling, Mycobacterium tuberculosis, forkhead-associated domain, FHA, phosphorylation, phosphothreonine, kinase http://podcasts.aaas.org/science_signaling/ScienceSignaling_090303.mp3 Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. Science Signaling Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090303.mp3 Tue, 03 Mar 2009 00:01:00 GMT no 14:50 Science Signaling, fibroblast growth factor receptor, FGFR, glioblastoma, kinase, kinetics, autophosphorylation http://podcasts.aaas.org/science_signaling/ScienceSignaling_090217.mp3 The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. Science Signaling The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090217.mp3 Tue, 17 Feb 2009 00:01:00 GMT no 15:21 Science Signaling, lymphocyte, osmotic stress, hyperosmolarity, guanine nucleotide exchange factor, Brx, NFAT5, spleen http://podcasts.aaas.org/science_signaling/ScienceSignaling_090203.mp3 Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. Science Signaling Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090203.mp3 Tue, 03 Feb 2009 00:01:00 GMT no 9:54 Science Signaling, mTOR, prostate cancer, rapamycin, TORC, cell growth, kinase inhibitor http://podcasts.aaas.org/science_signaling/ScienceSignaling_090127.mp3 Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Science Signaling Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090127.mp3 Tue, 27 Jan 2009 00:01:00 GMT no 9:50 Science Signaling, adipocyte, insulin, leptin, bone, fat, sympathetic nervous system, epinephrine, hormone, osteoblast, islet cells, pancreas, osteocalcin, adrenaline http://podcasts.aaas.org/science_signaling/ScienceSignaling_090113.mp3 The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. Science Signaling The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia. http://podcasts.aaas.org/science_signaling/ScienceSignaling_090113.mp3 Tue, 13 Jan 2009 00:01:00 GMT no 13:16 Science Signaling, hypoxia, HIF-1α, compartmentalization, oxygen, mAKAP, nuclear envelope, scaffold protein http://podcasts.aaas.org/science_signaling/ScienceSignaling_081216.mp3 Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. Science Signaling Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081216.mp3 Tue, 16 Dec 2008 00:01:00 GMT no 9:40 Science Signaling, CD3ε, T cell receptor, TCR, immunology, major histocompatibilty complex, MHC, antigen, immunoreceptor tyrosine-based activation motif, ITAM http://podcasts.aaas.org/science_signaling/ScienceSignaling_081202.mp3 Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. Science Signaling Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081202.mp3 Tue, 02 Dec 2008 00:01:00 GMT no 12:30 Science Signaling, signal transduction, ultraviolet light, UVB, radiation, DNA damage, apoptosis, JNK, ROCK1, Rho, kinase, JIP-3, MAPK http://podcasts.aaas.org/science_signaling/ScienceSignaling_081125.mp3 Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. Science Signaling Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. Petra May discusses new findings about a role for LRP1 in inhibiting inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081125.mp3 Tue, 25 Nov 2008 00:01:00 GMT no 11:03 Science Signaling, signal transduction, inflammation, immune system, immunity, secretase, protease, proteolytic processing, LRP, liproprotein receptor, LDL receptor, lipopolysaccharide, LPS http://podcasts.aaas.org/science_signaling/ScienceSignaling_081111.mp3 Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. Science Signaling Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081111.mp3 Tue, 11 Nov 2008 00:01:00 GMT no 10:35 Science Signaling, signal transduction, genetic screen, Wnt, Wingless, RNAi, proteomics, colon cancer http://podcasts.aaas.org/science_signaling/ScienceSignaling_081028.mp3 Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players. Science Signaling Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players. Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players.. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081028.mp3 Tue, 28 Oct 2008 00:01:00 GMT no 8:57 Science Signaling, signal transduction, NetPhorest, NetworKIN, kinome, database, phorphorylation, kinase, phosphatase, network http://podcasts.aaas.org/science_signaling/ScienceSignaling_081007.mp3 The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. Science Signaling The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response. http://podcasts.aaas.org/science_signaling/ScienceSignaling_081007.mp3 Tue, 07 Oct 2008 00:01:00 GMT no 7:07 Science Signaling, signal transduction, microbiology, periodontitis, gingivitis, virulence, fimbriae, CXCR4, TLR, bacteria http://podcasts.aaas.org/science_signaling/ScienceSignaling_080923.mp3 Bacteria secrete factors that regulate genes that contribute to virulence. Science Signaling Bacteria secrete factors that regulate genes that contribute to virulence. Bacteria secrete factors that regulate genes that contribute to virulence. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080923.mp3 Tue, 23 Sep 2008 00:01:00 GMT no 12:16 science signaling, signal transduction, microbiology, cholera, virulence, flagellum, secretion, tuberculosis, transcription, gene expression http://podcasts.aaas.org/science_signaling/ScienceSignaling_080805.mp3 Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. Science Signaling Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080805.mp3 Tue, 05 Aug 2008 00:01:00 GMT no 11:00 science, science signaling, signal transduction, nociception, ion channels, anesthetic, anesthesia, peripheral nervous system, pain http://podcasts.aaas.org/science_signaling/ScienceSignaling_080715.mp3 Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. Science Signaling Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080715.mp3 Tue, 15 Jul 2008 00:01:00 GMT no 10:54 science, science signaling, signal transduction, macrophage, immunity, cancer, bacterial infection, NF-kappaB, IKKbeta http://podcasts.aaas.org/science_signaling/ScienceSignaling_080617.mp3 Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. Science Signaling Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080617.mp3 Tue, 17 Jun 2008 00:01:00 GMT no 8:08 science, science signaling, signal transduction, neurobiology, glioma, brain, cancer, microvesicle, epidermal growth factor receptor, EGFR http://podcasts.aaas.org/science_signaling/ScienceSignaling_080506.mp3 Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Science Signaling Some glial cells can generate action potentials and are hypersensitive to ischemic injury. Some glial cells can generate action potentials and are hypersensitive to ischemic injury. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080506.mp3 Tue, 06 May 2008 00:01:00 GMT no 5:42 science, science signaling, signal transduction, neurobiology, neuroscience, glia, neuron, action potential, ischemia, myelin, NG2, oligodendrocyte http://podcasts.aaas.org/science_signaling/ScienceSignaling_080408.mp3 Mutations in the IGF-1 receptor are associated with longer life span in humans. Science Signaling Mutations in the IGF-1 receptor are associated with longer life span in humans. Mutations in the IGF-1 receptor are associated with longer life span in humans. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080408.mp3 Tue, 08 Apr 2008 00:01:00 GMT no 7:11 science, science signaling, signal transduction, life span, aging, longevity, growth hormone, genetics, insulin-like growth factor 1, centenarian http://podcasts.aaas.org/science_signaling/ScienceSignaling_080222.mp3 Glucose may stimulate the formation of fat tissue in muscle. Science Signaling Glucose may stimulate the formation of fat tissue in muscle. Glucose may stimulate the formation of fat tissue in muscle. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080222.mp3 Thu, 21 Feb 2008 23:59:00 GMT no 7:12 science, science signaling, signal transduction, stem cells, fat, adipose, diabetes, metabolism, glucose, cultured cells, cell biology http://podcasts.aaas.org/science_signaling/ScienceSignaling_080118.mp3 Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. Science Signaling Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. Visual activity decreases the abundance of a polymer that regulates cell adhesion during brain development. http://podcasts.aaas.org/science_signaling/ScienceSignaling_080118.mp3 Thu, 17 Jan 2008 23:59:00 GMT no 9:13 science, science signaling, signal transduction, neuroscience, GABA, critical period, brain, plasticity, polysialic acid, inhibitory neuron, development, mouse