Contents
14 May 2019
Vol 12, Issue 581
Vol 12, Issue 581
Focus
- The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
Interaction with membrane phospholipids restricts the localization of the DNA sensor cGAS and limits its activity.
Research Articles
- Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells
Single-cell data reveal the major transcriptional regulators for distinct macrophage states.
- The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1
The PI3K signaling adaptor BCAP limits inflammasome activation by interacting with the caspase-1 inhibitor Flightless-1.
Editors' Choice
- Turning off cellular stress
Independently of autophagy, the kinases ULK1/2 promote stress granule disassembly and prevent the development of skeletal muscle disease.
About The Cover
Online Cover This week features a Research Article that describes the transcriptional regulators responsible for determining distinct macrophage states. Single-cell analyses of mRNA and proteins characterized the pro- and anti-inflammatory macrophage states induced by the microbial product LPS and the free fatty acid palmitate, both of which act through the receptor TLR4. The image shows immunofluorescence detection of various pro- and anti-inflammatory factors in primary human macrophages. [Image: Fischer et al./Science Signaling]