Contents

Research Articles

• BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1

  By Cyril Anastasi, Patricia Rousselle, Maya Talantikite, Agnès Tessier, Caroline Cluzel, Alice Bachmann, Natacha Mariano, Mélissa Dussoyer, Lindsay B. Alcaraz, Laëtitia Fortin, Alexandre Aubert, Frédéric Delolme, Naïma El Kholti, Jean Armengaud, Pierre Fournié, Céline Auxenfans, Ulrich Valcourt, Sandrine Vadon-Le Goff, Catherine Moali

  Science Signaling07 Jul 2020 Full AccessRestricted Access

  BMP-1–mediated cleavage of TSP-1 reduces cell adhesion and promotes TGF-β signaling.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity

  By Dominic P. Byrne, Safal Shrestha, Martin Galler, Min Cao, Leonard A. Daly, Amy E. Campbell, Claire E. Eyers, Elizabeth A. Veal, Natarajan Kannan, Patrick A. Eyers

  Science Signaling07 Jul 2020 Full AccessRestricted Access

  The catalytic activity of multiple Ser/Thr kinases is regulated through a conserved Cys-based redox mechanism.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

  By Safal Shrestha, Samiksha Katiyar, Carlos E. Sanz-Rodriguez, Nolan R. Kemppinen, Hyun W. Kim, Renuka Kadirvelraj, Charalampos Panagos, Neda Keyhaninejad, Maxwell Colonna, Pradeep Chopra, Dominic P. Byrne, Geert J. Boons, Esther van der Knaap, Patrick A. Eyers, Arthur S. Edison, Zachary A. Wood, Natarajan Kannan

  Science Signaling07 Jul 2020 Full AccessRestricted Access

  Evolutionarily conserved cysteine residues mediate the sensitivity of the metabolic kinase FN3K to shifts in redox status.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials