Contents

Research Articles

• TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis

  By Mary L. Uribe, Maik Dahlhoff, Rajbir N. Batra, Nishanth B. Nataraj, Yuya Haga, Diana Drago-Garcia, Ilaria Marrocco, Arunachalam Sekar, Soma Ghosh, Itay Vaknin, Sacha Lebon, Lior Kramarski, Yasuo Tsutsumi, Inpyo Choi, Oscar M. Rueda, Carlos Caldas, Yosef Yarden

  Science Signaling22 Jun 2021 Full AccessRestricted Access

  Examination of genes repressed hours after exposure to the growth factor EGF reveals that TSHZ2 restricts mitosis.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Combinatorial phosphorylation modulates the structure and function of the G protein γ subunit in yeast

  By Zahra Nassiri Toosi, Xinya Su, Ruth Austin, Shilpa Choudhury, Wei Li, Yui Tik Pang, James C. Gumbart, Matthew P. Torres

  Science Signaling22 Jun 2021 Full AccessRestricted Access

  Distinct phosphorylation patterns in the intrinsically disordered N terminus of Gγ have functional consequences in yeast.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation

  By Sarah E. Minnis-Lyons, Sofía Ferreira-González, Niya Aleksieva, Tak Yung Man, Victoria L. Gadd, Michael J. Williams, Rachel V. Guest, Wei-Yu Lu, Benjamin J. Dwyer, Tam Jamieson, Colin Nixon, Noemi Van Hul, Frederic P. Lemaigre, John McCafferty, Isabelle A. Leclercq, Owen J. Sansom, Luke Boulter, Stuart J. Forbes

  Science Signaling22 Jun 2021 Full AccessRestricted Access

  Notch signaling promotes progenitor cell proliferation but inhibits hepatocyte differentiation during liver repair.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials