Contents
18 June 2019
Vol 12, Issue 586
Vol 12, Issue 586
Research Articles
- l-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy
Dietary l-serine supplements correct NMDAR deficiency and neurodevelopmental defects in a pediatric patient.
- BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons
The RNA binding protein hnRNP K mediates BDNF-induced proteome remodeling at the neuronal synapse.
Editors' Choice
- New connections: NMDARs in learning and memory
Studies provide critical insight into the roles and regulation of NMDA receptors in learning and memory.
About The Cover
Online Cover This week features a Research Article that shows how dietary ʟ-serine supplementation corrects NMDAR deficiency and neurodevelopmental defects in a pediatric patient with Rett-like syndrome. The image shows immunofluorescent staining of cultured neurons expressing GFP-tagged NMDAR subunit GluN2B. [Image: Soto et al./Science Signaling]