Contents
03 August 2021
Vol 14, Issue 694
Vol 14, Issue 694
Research Articles
- β-Arrestin–dependent ERK signaling reduces anxiety-like and conditioned fear–related behaviors in mice
β-Arrestin signaling may mediate the fear- and anxiety-relieving effects as well as adverse events of opioids.
- A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation
The enzyme NDPK-D promotes changes in mitochondrial function that support inflammasome activation.
Review
- Emerging roles of PLCγ1 in endothelial biology
The enzyme PLCγ1 is an important effector of key signaling pathways in endothelial cells.
Editors' Choice
- Intercellular cross-talk curbs Alzheimer’s disease
Astrocyte-derived IL-3 activates microglia to clear β-amyloid aggregates in a mouse model of Alzheimer’s disease.
About The Cover
Online Cover This week features a Research Article that shows that opioids may suppress fear and anxiety through β-arrestin signaling. The image shows immunofluorescent staining for phosphorylated ERK (red) in brain slices from mice treated with saline or an opioid receptor agonist. [Image: Ko et al./Science Signaling]
