Contents

Research Articles

• Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

  By Lisa M. Grove, Maradumane L. Mohan, Susamma Abraham, Rachel G. Scheraga, Brian D. Southern, James F. Crish, Sathyamangla V. Naga Prasad, Mitchell A. Olman

  Science Signaling12 Nov 2019 Full AccessRestricted Access

  Profibrotic signaling by the mechanosensitive ion channel TRPV4 requires TRPV4-PI3Kγ complexes at the plasma membrane.

  • Editor's Summary
  • Abstract
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• The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

  By Masato Morikawa, Yoshihide Mitani, Katarina Holmborn, Taichi Kato, Daizo Koinuma, Junko Maruyama, Eleftheria Vasilaki, Hirofumi Sawada, Mai Kobayashi, Takayuki Ozawa, Yasuyuki Morishita, Yasumasa Bessho, Shingo Maeda, Johan Ledin, Hiroyuki Aburatani, Ryoichiro Kageyama, Kazuo Maruyama, Carl-Henrik Heldin, Kohei Miyazono

  Science Signaling12 Nov 2019 Full AccessRestricted Access

  BMP signaling induces a transcription factor that may block pulmonary arterial hypertension from developing.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production

  By Sumbul Afroz, Shama, Srikanth Battu, Shaikh Matin, Sabrina Solouki, Jessica P. Elmore, Gillipsie Minhas, Weishan Huang, Avery August, Nooruddin Khan

  Science Signaling12 Nov 2019 Full AccessRestricted Access

  The amino acid starvation mimetic halofuginone augments the neutralizing antibody response to dengue virus vaccination.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials