Contents
23 April 2019
Vol 12, Issue 578
Vol 12, Issue 578
Research Article
- Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization
SOCE mediated by ORAI1 affects the metabolism, redox status, and function of enamel cells in teeth.
Research Resources
- Tracing the origin and evolution of pseudokinases across the tree of life
Pseudokinases are prevalent across species and contribute diverse, noncatalytic signaling functions.
- Proximity biotinylation identifies a set of conformation-specific interactions between Merlin and cell junction proteins
The tumor suppressor Merlin interacts with cell junction–associated proteins and with the proapoptotic protein ASPP2.
Editors' Choice
- Driving expression of leptin
The transcriptional regulator Egr1 mediates the insulin-dependent production of leptin by adipocytes.
About The Cover
Online Cover This week features a Research Article that reveals that SOCE mediated by ORAI1 affects the metabolism, redox status, and function of enamel cells in teeth. The image is a high-magnification micrograph of the enamel of teeth from an OraiK14 mouse after acid etching. [Image: Eckstein et al./Science Signaling]