Contents
10 December 2019
Vol 12, Issue 611
Vol 12, Issue 611
Research Article
- A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to β-catenin
Interactions between the DIX domains of Dishevelled and Axin drive repression of the β-catenin destruction complex.
Research Resource
- Metabolic rewiring of the hypertensive kidney
Multi-omics analyses reveal that metabolic changes occur early in hypertension-induced kidney disease.
Editors' Choice
- Mutations that TANK a kinase
ALS-associated mutations in the kinase TBK1 with the same pathological outcome affect distinct signaling pathways.
About The Cover
Online Cover This week features a Research Article that shows that metabolic changes occur early in hypertension-induced kidney disease, as revealed by metabolomics, phosphoproteomics, and proteomics analyses, suggesting that metabolic interventions could be potentially useful in treating this disease. The image shows a kidney section from a hypertensive rat. [Image: Rinschen et al./Science Signaling]
