Contents
19 January 2021
Vol 14, Issue 666
Vol 14, Issue 666
Focus
- The double life of TLR2
TLR2 located in the endothelium promotes angiogenesis and inflammation.
Research Articles
- Endothelial TLR2 promotes proangiogenic immune cell recruitment and tumor angiogenesis
Toll-like receptor 2 contributes to innate immune responses in endothelial cells as well as in immune cells.
- NF-κB responds to absolute differences in cytokine concentrations
The behavior of the NF-κB pathway as a differentiator circuit enables the pathway to track changes in cytokine dose.
- Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation
Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.
Editors' Choice
- Refining precision immunotherapy
Two studies show why some, but not all, MMR-deficient tumors are sensitive to immunotherapy.
About The Cover
Online Cover This week features a Research Article that shows that the Toll-like receptor TLR2 in endothelial cells contributes to innate immune responses. The image shows endothelial cell–specific TLR2 staining in thymus tissue from reporter mice. [Image: McCoy et al./Science Signaling]
