Contents

Research Articles

• CRAC channels regulate astrocyte Ca²⁺ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

  By Anna B. Toth, Kotaro Hori, Michaela M. Novakovic, Natalie G. Bernstein, Laurie Lambot, Murali Prakriya

  Science Signaling21 May 2019 Full AccessRestricted Access

  Astrocyte store-operated Ca²⁺ entry controls gliotransmitter release to alter hippocampal excitability.

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  • Abstract
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• mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β₁–induced collagen biosynthesis

  By Brintha Selvarajah, Ilan Azuelos, Manuela Platé, Delphine Guillotin, Ellen J. Forty, Greg Contento, Hannah V. Woodcock, Matthew Redding, Adam Taylor, Gino Brunori, Pascal F. Durrenberger, Riccardo Ronzoni, Andy D. Blanchard, Paul F. Mercer, Dimitrios Anastasiou, Rachel C. Chambers

  Science Signaling21 May 2019 Full AccessRestricted Access

  Through mTORC1 signaling, TGF-β₁ stimulates glycine synthesis from glucose to support collagen production in lung fibroblasts.

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• IRF2 transcriptionally induces GSDMD expression for pyroptosis

  By Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O'Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram, Vishva M. Dixit

  Science Signaling21 May 2019 Full AccessRestricted Access

  Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.

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