Contents
10 August 2021
Vol 14, Issue 695
Vol 14, Issue 695
Focus
- Outside in and brakes off for lymphatic growth
Blocking the intracellular brakes on VEGFR3 signaling yields functional lymphatic growth (Kataru et al., in 10 August 2021 issue).
Research Articles
- Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function
The lymphatic network can be expanded in size and function by enhancing intracellular VEGFR3 signaling.
- Differential regulation of G protein signaling in Arabidopsis through two distinct pathways that internalize AtRGS1
Segregated pathways enable AtRGS1 endocytosis to transduce signal-specific responses in Arabidopsis.
Editors' Choice
- An alternative to mitophagy
Cancer cells can recycle mitochondrial components through a pathway that does not require autophagosomes.
About The Cover
Online Cover This week features a Research Article that shows that the lymphatic network can be expanded in size and function by deleting the gene encoding PTEN, a lipid phosphatase that inhibits signaling downstream of the lymphangiogenic receptor VEGFR3 (see also the associated Focus). The image shows the long-lasting effects of PTEN deficiency in lymphatic endothelial cells on the density of lymphatic vessels (green) in mouse intestine. [Image: Kataru et al./Science Signaling]
