Contents
20 October 2020
Vol 13, Issue 654
Vol 13, Issue 654
Focus
- Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S
Dimerization limits the autoubiquitination-driven breakdown of the E2 UBE2S (Liess et al., in 20 October 2020 issue).
Research Articles
- SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin
Aspirin represses drug efflux pump expression and enhances chemotherapy efficacy in stem-like breast cells.
- Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S
The E2 enzyme UBE2S may be stored as a dimer to prevent its degradation between mitotic cycles.
- Interclass GPCR heteromerization affects localization and trafficking
Serotonin 5-HT2A receptors heterodimerize with mGluR2 and trigger internalization.
Editors' Choice
- Palmitoylation and colitis
Interrupting the palmitoylation-depalmitoylation cycle of the transcriptional regulator STAT3 relieves IBD symptoms in mice.
About The Cover
Online Cover This week features a Research Article that shows that aspirin boosts the efficacy of chemotherapy by repressing the expression of a gene encoding a drug efflux pump in breast cancer stem cells. The image shows an invasive ductal carcinoma infiltrating breast adipose tissue. [Image: Jose Calvo/Science Source]
