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Cover story: Cell damage without inflammation

A multifunctional Vibrio cholerae toxin simultaneously damages cells and suppresses inflammation

James Cavallini/Science Source
Oligomerizing for optimal activity

Ligand binding triggers the oligomerization of TNFR1 into trimers and higher-order oligomers

Karathanasis et al./Science Signaling
Free this week: An accessory protein skews signaling

An accessory protein suppresses β-arrestin–dependent signaling and constitutive activity of the ghrelin receptor

Ramón Andrade, 3Dciencia/Science Source

Contents

14 January 2020
Vol 13, Issue 614

Research Articles
- The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapse
  
  By Patrick J. Woida, Karla J. F. Satchell
  
  Science Signaling14 Jan 2020 Full AccessRestricted Access
  
  The multifunctional MARTX toxin of Vibrio cholerae damages host cells and suppresses the innate response to that damage.
  
  Editor's Summary
  
  Abstract
  
  Full Text
  
  PDF
  
  Supplementary Materials
- Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells
  
  By Christos Karathanasis, Juliane Medler, Franziska Fricke, Sonja Smith, Sebastian Malkusch, Darius Widera, Simone Fulda, Harald Wajant, Sjoerd J. L. van Wijk, Ivan Dikic, Mike Heilemann
  
  Science Signaling14 Jan 2020 Full AccessRestricted Access
  
  Ligand binding triggers the oligomerization of TNFR1 monomers and dimers into trimers and higher-order oligomers.
  
  Editor's Summary
  
  Abstract
  
  Full Text
  
  PDF
  
  Supplementary Materials
Editors' Choice
- Predicting resistance to KRAS inhibitors
  
  By Leslie K. Ferrarelli
  
  Science Signaling14 Jan 2020 Full AccessRestricted Access
  
  Studies identify common targets for preventing resistance to KRAS inhibitors.
  
  Abstract
  
  Full Text

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows how a multifunctional Vibrio cholerae toxin simultaneously damages cells and suppresses inflammation. The image is a colorized light micrograph of V. cholerae. [Image: James Cavallini/Science Source]