Contents
Vol 1, Issue 10
Contents
Perspective
- Matrix Elasticity, Cytoskeletal Tension, and TGF-β: The Insoluble and Soluble Meet
Extracellular matrix stiffness regulates the equilibrium between storage and release of matrix-bound transforming growth factor-β.
Editors' Choice
- Responding to DNA
Viral, bacterial, and even host DNA trigger processing and release of the proinflammatory mediator interleukin-1β by activating the inflammasome.
- Alzheimer’s Signals
A ligand is identified that activates processing of the β-amyloid precursor protein to control neurogenesis.
- Bone Notches
Mesenchymal progenitor cells in the bone marrow are kept in check by Notch signaling, which inhibits their differentiation into osteoblasts.
- Predisposed to a Long Life?
Human IGF-1 receptor mutations may be associated with a predisposition toward long life.
- Satisfied Worms
Worms stop eating and start resting because of signals such as insulin, cGMP, and TGF-β.
- Directly Modulating Glucose Homeostasis
Competing glycosylation and phosphorylation of a single amino acid in a transcriptional coactivator regulate nutrient and energy sensing pathways and may contribute to diabetes.
- Mitochondrial Proteases Required for Survival
Activation of a mitochondrial protease localized to the intermembrane space appears to be important for survival of immune cells and neurons.
- Plants Going TOPLESS
A transcriptional corepressor is part of the protein complex that inhibits developmental gene activation in Arabidopsis until the growth hormone auxin triggers its degradation.
- Toward a Designer GAS Vaccine
Mutating a cell-surface virulence protein on strep bacteria stabilizes its structure, minimizing its inflammatory side effects and potentially making it a better vaccine.
