11 March 2008
Vol 1, Issue 10
  • Contents

    • Perspective

    • Editors' Choice

      • Responding to DNA

        Viral, bacterial, and even host DNA trigger processing and release of the proinflammatory mediator interleukin-1β by activating the inflammasome.

      • Alzheimer’s Signals

        A ligand is identified that activates processing of the β-amyloid precursor protein to control neurogenesis.

      • Bone Notches

        Mesenchymal progenitor cells in the bone marrow are kept in check by Notch signaling, which inhibits their differentiation into osteoblasts.

      • Predisposed to a Long Life?

        Human IGF-1 receptor mutations may be associated with a predisposition toward long life.

      • Satisfied Worms

        Worms stop eating and start resting because of signals such as insulin, cGMP, and TGF-β.

      • Directly Modulating Glucose Homeostasis

        Competing glycosylation and phosphorylation of a single amino acid in a transcriptional coactivator regulate nutrient and energy sensing pathways and may contribute to diabetes.

      • Mitochondrial Proteases Required for Survival

        Activation of a mitochondrial protease localized to the intermembrane space appears to be important for survival of immune cells and neurons.

      • Plants Going TOPLESS

        A transcriptional corepressor is part of the protein complex that inhibits developmental gene activation in Arabidopsis until the growth hormone auxin triggers its degradation.

      • Toward a Designer GAS Vaccine

        Mutating a cell-surface virulence protein on strep bacteria stabilizes its structure, minimizing its inflammatory side effects and potentially making it a better vaccine.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses the importance of cell-generated mechanical tension in the release of matrix-bound growth factors. The image depicts the release of transforming growth factor-β from a myofibroblast on a stiff matrix. [Image: Christopher Bickel, AAAS]