18 March 2008
Vol 1, Issue 11
  • Contents

    • Editors' Choice

      • Pyruvate Kinase for Cancerous Metabolism

        The M2 isoform of pyruvate kinase, which appears to be required for tumorigenesis, is regulated by interaction with tyrosine-phosphorylated peptides.

      • Unfolding Possible Cancer Target

        The unfolded protein response of the endoplasmic reticulum links signaling pathways controlling metabolism and cell survival.

      • Yorkie’s Elusive Partner

        Two studies identify Scalloped as the transcription factor that activates the expression of genes antagonized by the Hippo pathway.

      • Saved from Destruction

        BAFF promotes B cell survival by stimulating TRAF3 depletion.

      • Keeping Things Moving

        The dynein regulator Nudel facilitates migration by helping to keep Cdc42 active at the front of the cell.

      • Synthetic Biology in Action

        A yeast signaling pathway acquires new regulatory properties (such as adaptation) when additional protein-protein interaction sites are engineered into a scaffolding protein.

      • A Working Model of Working Memory

        Stronger synapses induced by calcium currents are responsible for working memory rather than the more metabolically expensive action potential firing, as had been thought.

      • Stress Relief in Alcoholism

        A drug that inhibits a neural signaling pathway linked to behavioral stress may be a useful therapy in preventing relapse in alcoholics.

About The Cover

COVER This week's issue contains three new entries to ST NetWatch, including DrugBank, a tool to examine the effects of drugs on signaling pathways; MINT, a database of protein-protein interactions; and Ask a Scientist, a Web site at which you can post questions for scientists. [Image: Christopher Bickel, AAAS]