25 March 2008
Vol 1, Issue 12
  • Contents

    • Editorial Guide

    • Meeting Report

    • Presentations

    • Podcasts

    • Editors' Choice

      • An Inside Job?

        TLR4 appears to stimulate TIRAP-MyD88 signaling from the cell surface and to initiate TRAM-TRIF signaling only after internalization.

      • Paradoxical Signaling

        A cell cycle–associated kinase phosphorylates the transcription factor FOXO1, which activates transcription of a regulator of mitosis.

      • The SKNy on Old Worms

        The C. elegans transcription factor SKN-1, whose activity is inhibited by insulin-like signaling, turns on pathways that lead to a longer life span.

      • Signaling Who Does Which Chores

        Insulin/insulin-like growth factor signaling is associated with regulation of social behavior in honey bees.

      • Hh and BMP Converge on Atoh1

        Atoh1 regulation is central to granule cell development and medulloblastoma.

      • BDNF + Protein Synthesis = Synaptic Plasticity

        Pairing of stimuli in hippocampal cells induces secretion of the growth factor BDNF, causing enlargement of individual spines and strengthening of synapses.

      • Faulty Scaffolding and Cancer

        One type of non-Hodgkin’s lymphoma is caused by mutations in a scaffolding protein that inappropriately activate an inflammatory signaling pathway.

      • Glutamate at the Clot

        The neurotransmitter glutamate contributes to arterial blockage by thrombosis.

About The Cover

Cover image expansion

COVER This week, Science Signaling launches four new Sections and features a Meeting Report and three Presentations that highlight talks from the 11th Joint Meeting of the Signal Transduction Society (STS), Signal Transduction: Receptors, Mediators and Genes, which took place from the 1st to the 3rd of November 2007 in Weimar, Germany. [Image: L. Bryan Ray, AAAS]