Contents

Contents

• Review

  • Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?

    By Martin Lackmann, Andrew W. Boyd

    Science Signaling15 Apr 2008 : re2 Full AccessRestricted Access

    Eph receptors and their ephrin ligands coordinate cell-positioning programs during development and oncogenesis.

    • Abstract
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• Journal Club

  • GABA Effects on Neurogenesis: An Arsenal of Regulation

    By Ti-Fei Yuan

    Science Signaling15 Apr 2008 : jc1 Full AccessRestricted Access

    GABA regulates neurogenesis in various circumstances.

    • Abstract
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• Editors' Choice

  • Bacterial TIR Domains

    By Nancy R. Gough

    Science Signaling15 Apr 2008 : ec129 Full AccessRestricted Access

    Bacteria interfere with Toll-like receptor signaling by secreting proteins with TIR domains that compete with the MyD88 adaptor.

    • Abstract

  • Follow the Endothelin

    By L. Bryan Ray

    Science Signaling15 Apr 2008 : ec130 Full AccessRestricted Access

    Endothelin derived from blood vessels helps direct sympathetic neurons to their target organs.

    • Abstract

  • Keeping Axons on Track

    By Pamela J. Hines

    Science Signaling15 Apr 2008 : ec131 Full AccessRestricted Access

    In mice, axons carrying signals from spinal cord to muscle are kept separate from those going in the opposite direction by ephrin signaling between them.

    • Abstract

  • Slow Breathing

    By Elizabeth M. Adler

    Science Signaling15 Apr 2008 : ec132 Full AccessRestricted Access

    AKAP121 degradation leads to decreased mitochondrial metabolism under hypoxic conditions.

    • Abstract

  • Balancing Stability and Dynamics

    By Annalisa M. VanHook

    Science Signaling15 Apr 2008 : ec133 Full AccessRestricted Access

    Precise control of adhesive properties is essential for collective migration.

    • Abstract

  • Bcl2 Blocks DNA Repair

    By Nancy R. Gough

    Science Signaling15 Apr 2008 : ec134 Full AccessRestricted Access

    In the nucleus, Bcl2 interacts with apurinic/apyrimidinic endonuclease 1 (APE1) to inhibit DNA repair.

    • Abstract

  • Radioprotection: Taking the Toll Road

    By Paula A. Kiberstis

    Science Signaling15 Apr 2008 : ec135 Full AccessRestricted Access

    A drug that triggers the pathway that cancer cells use to avoid death can protect healthy cells from the harmful effects of radiation treatment.

    • Abstract

  • Fast Receptors in Every Respect

    By Peter Stern

    Science Signaling15 Apr 2008 : ec136 Full AccessRestricted Access

    Desensitized glutamate receptors are exchanged for functional ones through lateral movement within membranes to help maintain fast excitatory neurotransmission.

    • Abstract