Contents
Vol 1, Issue 16
Contents
Editors' Choice
- Don’t Try This at Home
Genetic rewiring of transcriptional regulatory networks in bacteria is surprisingly well tolerated.
- Just When You Thought It Was Pseudo
The pseudokinase Ca2+/calmodulin-activated serine-threonine kinase (CASK), which was assumed to be catalytically inactive, has kinase activity in vivo.
- Enhancing the Immune Response
Aluminum-containing adjuvants stimulate dendritic cells by means of uric acid.
- Receptor-dsRNA-Receptor
Two horseshoe-shaped monomers of an innate immunity receptor bind to double-stranded RNA through carboxyl-terminal dimerization, ultimately triggering inflammation.
- Little Change, Large Consequence
Flagellar proteins from two bacterial species diverge in their coiled-coil regions; only one triggers an immune response, which may have driven their evolutionary divergence.
- NADPH Sensor Regulates NO Production
When NADPH is decreased, HSCARG appears to inhibit argininosuccinate synthetase to limit nitric oxide production.
- Nuclear Lamin for Gene Silencing
Silencing of the bam gene in Drosophila involves Decapentaplegic (Dpp) signaling and the nuclear membrane protein Otefin.
- Autonomous Tracheal Sprouting
HIF is required for hypoxia-induced tracheal sprouting in Drosophila but not for normal development.
- The Yin and Yang of Neuronal Maintenance
Modeling and experiments show that neurons survive during development when neuronal sensitization to survival signals outweighs antagonistic signals for cell death.
- Thinking Globally, Acting Locally
Localized regulation of translation may be more widespread than previously thought.
- Cellular Orienteering
A developmental signal causes clustering of membrane-associated proteins (including its receptor) at one end of the cell, marking the cell's polarity for directional movement.
- Putting β-Catenin on the Rac
During canonical Wnt signaling, nuclear translocation of β-catenin involves a pathway that includes PI3K, Rac1, and JNK2.
