Contents
Vol 1, Issue 17
Contents
Perspectives
- Notch Signaling in Osteoblasts
Notch signaling plays a role in bone remodeling by inhibiting the differentiation of osteoblasts and osteoclasts.
- Back from the Dormant Stage: Second Messenger Cyclic ADP-Ribose Essential for Toxoplasma gondii Pathogenicity
The protozoan parasite Toxoplasma gondii uses a plant-like signaling pathway to exit host cells.
Editors' Choice
- Genetics of Schizophrenia
Patients with schizophrenia carry multiple small deletions and duplications in their DNA that are associated nonrandomly with neuronal signaling and brain development pathways.
- How Do Bugs Smell?
Insect odorant receptors look a bit like GPCRs but appear to function as ligand-gated ion channels.
- From Dendrite to Dendritic
A scaffold protein well known for its role in neuronal synapse formation is required for efficient activation of naïve CD4+ T cells by dendritic cells.
- Gamete Interactions
Sexual reproduction in flowering plants, parasites, and animals has some intriguing similarities.
- NO Link Between Notch and Inflammation?
NO is able to reduce the activity of the Notch intracellular domain in an in vitro model of inflammation.
- Distinctive Individual Smells
Mice can recognize the pheromones from individual mice through unique patterns of receptor activation in the vomeronasal organ.
- Keeping the Balance
The phosphatase SHP-1 inhibits TLR-mediated production of proinflammatory cytokines while enhancing the production of type I interferons.
- Integrating Different Signals
GRK2 integrates adhesion- and GPCR-based signals to promote epithelial cell migration.
- Exploiting Surface Phosphatidylserine
Precise regulation of phosphatidylserine localization is important for engulfment of both viruses and eukaryotic cells.
