29 April 2008
Vol 1, Issue 17
  • Contents

    • Perspectives

    • Editors' Choice

      • Genetics of Schizophrenia

        Patients with schizophrenia carry multiple small deletions and duplications in their DNA that are associated nonrandomly with neuronal signaling and brain development pathways.

      • How Do Bugs Smell?

        Insect odorant receptors look a bit like GPCRs but appear to function as ligand-gated ion channels.

      • Damage Control

        The bacterial checkpoint protein DisA has diadenylate cyclase activity.

      • From Dendrite to Dendritic

        A scaffold protein well known for its role in neuronal synapse formation is required for efficient activation of naïve CD4+ T cells by dendritic cells.

      • Gamete Interactions

        Sexual reproduction in flowering plants, parasites, and animals has some intriguing similarities.

      • NO Link Between Notch and Inflammation?

        NO is able to reduce the activity of the Notch intracellular domain in an in vitro model of inflammation.

      • Distinctive Individual Smells

        Mice can recognize the pheromones from individual mice through unique patterns of receptor activation in the vomeronasal organ.

      • Keeping the Balance

        The phosphatase SHP-1 inhibits TLR-mediated production of proinflammatory cytokines while enhancing the production of type I interferons.

      • Integrating Different Signals

        GRK2 integrates adhesion- and GPCR-based signals to promote epithelial cell migration.

      • Exploiting Surface Phosphatidylserine

        Precise regulation of phosphatidylserine localization is important for engulfment of both viruses and eukaryotic cells.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that describes how a plant-like signaling pathway in the protozoan pathogen Toxoplasma gondii results in the secretion of proteins involved in its escape from its host cell, a finding that raises hopes for new approaches to combat these parasites. The image depicts T. gondii (in green) during the lytic stage. [Image: Preston Huey, AAAS]