06 May 2008
Vol 1, Issue 18
  • Contents

    • Perspectives

    • Podcast

    • Editors' Choice

      • Toxin Targets T Cells

        The aryl hydrocarbon receptor, known for binding environmental toxins, regulates the balance of pro- and anti-inflammatory responses in the immune system.

      • Kinases in the Polyadenylation Complex

        The noncanonical poly(A) polymerase Star-PAP is part of an RNA processing complex that includes both lipid and protein kinases.

      • Alternative Activation

        The activation of Ca2+/CaM-dependent protein kinase II (CaMKII) by reactive oxygen species has important implications for cardiac function.

      • Mitochondria as Drivers of Metastasis

        Mutations in mitochondrial DNA that cause enhanced production of reactive oxygen species can increase the propensity of tumor cells to metastasize.

      • Notching Up Tumor Progression

        Tumor cell epithelial-mesenchymal transition in response to hypoxia depends on Notch signaling.

      • Bipolar Order

        The Frizzled planar cell polarity pathway patterns elements oriented along different axes in the same polarized tissue.

      • Synaptojanin Protects Synaptic Function

        Treatment of neurons with oligomeric Aβ42 reduces the abundance of membrane PtdIns(4,5)P2, an effect that is mediated in part by a synaptic phosphatase.

      • Common Senses

        Experiments in a sea anemone suggest that one of the ancestral functions of the FGF pathway may have been inducing sensory organs.

      • A Sense of Danger in the Air

        A large multiprotein complex detects particulate airborne pollutants that have been taken up by immune cells in the lung and initiates a potent inflammatory response.

      • Signaling Survival Strategies

        A well-studied kinase is shown to be unexpectedly phosphorylated and inhibited by mitogen-activated protein kinase, and this modification activates cell-survival pathways.

      • Unintentional Uptake

        A lipoprotein in human blood protects against an African parasite by binding to a parasite receptor and triggering uptake of the lipoprotein, which contains a toxic component.