Contents
Vol 1, Issue 19
Contents
Perspective
- TCR Triggering by the pMHC Complex: Valency, Affinity, and Dynamics
Multiple models compete to explain T cell receptor activation.
Review
- Is Zinc a Neuromodulator?
Experiments with metal chelators and genetically modified mice provide the best means for determining whether zinc acts as a regulator of synaptic activity.
Editors' Choice
- A Deadly Gift
Membrane microvesicles provide a mechanism for horizontal transfer of the transformed phenotype.
- Balancing Act
The phosphatase Prl-3, previously associated with metastasis, is encoded by a p53-inducible gene that has opposing effects on the cell cycle depending on its abundance.
- Prion Protein Protection
Mice null for the gene that encodes prion protein show altered electrophysiological properties of NMDA-type glutamate receptors.
- Faster Than a Speeding Molecule
Cytoplasmic proteins can be activated by mechanical stress faster than by pathways that rely on diffusion of intracellular molecules.
- A Window into the Dynamics of Rab5 Activity
Live-cell imaging of Rab5 activation during phagocytosis enables development of a model of its activation through the delivery by microtubules of Gapex-5.
- ACEing Lipid Metabolism
The renin-angiotensin system regulates fat accumulation by altering global metabolism.
- Home Is Where the Hearth Is
An olfactory neuron in Caenorhabditis elegans also senses the ambient temperature and is necessary for worms’ propensity to seek out the temperature at which they were raised.
- Identifying Receptor-Ligand Pairs
A systematic, functional screen of extracellular proteins in yeast identified a previously unknown receptor-ligand pair: the cytokine interleukin-34 and its receptor.
- Wholesale Heat Shock
Activation of a heat-sensitive sensory neuron in the worm Caenorhabditis elegans unexpectedly triggers a heat-shock response throughout the animal.
