13 May 2008
Vol 1, Issue 19
  • Contents

    • Perspective

    • Review

      • Is Zinc a Neuromodulator?

        Experiments with metal chelators and genetically modified mice provide the best means for determining whether zinc acts as a regulator of synaptic activity.

    • Editors' Choice

      • A Deadly Gift

        Membrane microvesicles provide a mechanism for horizontal transfer of the transformed phenotype.

      • Balancing Act

        The phosphatase Prl-3, previously associated with metastasis, is encoded by a p53-inducible gene that has opposing effects on the cell cycle depending on its abundance.

      • Prion Protein Protection

        Mice null for the gene that encodes prion protein show altered electrophysiological properties of NMDA-type glutamate receptors.

      • Faster Than a Speeding Molecule

        Cytoplasmic proteins can be activated by mechanical stress faster than by pathways that rely on diffusion of intracellular molecules.

      • A Window into the Dynamics of Rab5 Activity

        Live-cell imaging of Rab5 activation during phagocytosis enables development of a model of its activation through the delivery by microtubules of Gapex-5.

      • ACEing Lipid Metabolism

        The renin-angiotensin system regulates fat accumulation by altering global metabolism.

      • Home Is Where the Hearth Is

        An olfactory neuron in Caenorhabditis elegans also senses the ambient temperature and is necessary for worms’ propensity to seek out the temperature at which they were raised.

      • Identifying Receptor-Ligand Pairs

        A systematic, functional screen of extracellular proteins in yeast identified a previously unknown receptor-ligand pair: the cytokine interleukin-34 and its receptor.

      • Wholesale Heat Shock

        Activation of a heat-sensitive sensory neuron in the worm Caenorhabditis elegans unexpectedly triggers a heat-shock response throughout the animal.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses a number of models that describe how interactions between various molecules on the surfaces of antigen-presenting cells (APCs) and T lymphocytes cause T cell receptor (TCR) triggering. The image shows the clustering of receptors at the immunological synapse formed between an APC and a T cell. [Image: Chris Bickel, AAAS]