08 January 2008
Vol 1, Issue 1
  • Contents

    • Editorial Guide

      • 2007: Signaling Breakthroughs of the Year

        This year's advances span research into the signals that regulate the state of chromatin in the cell nucleus to those signals that modulate the social behavior of organisms.

    • Perspective

    • Editors' Choice

      • An RGS for PI3K

        Regulator of G protein signaling 13 (RGS13) interacts with the p85 subunit of PI3K to inhibit mast cell degranulation.

      • Contraction-Mediated Release of TGF-β1

        Integrin-mediated release of latent TGF-β1 from the extracellular matrix involves the mechanical stress of cell contraction.

      • Reduced to Activation

        Extracellular thioredoxin activates TRPC5 channels and heteromultimers by breaking a disulphide bridge.

      • A STIM for Resting Cells

        A key regulatory protein helps hold constant basal concentrations of calcium in the cell.

      • Transporting Behavior?

        Glial modulation of extracellular glutamate concentration and glutamatergic transmission affects male Drosophila courtship behavior.

      • Changing Her Ways

        Sex peptide receptor, a GPCR, mediates postmating changes in female behavior.

      • Invasion Signal

        GEP100, an activator of the small GTPase Arf6, mediates EGF-dependent tumor cell invasiveness.

      • Synaptic Metaplasticity

        During continuous sensory stimulation, NMDA receptors in the mouse cortex switch from enhancing synaptic potentiation to opposing it.

      • The Ant and the Butterfly

        Because they are coated with a specific chemical, the larvae of a butterfly are adopted and cared for by an ant species, a relationship that shows signs of ongoing coevolution.

About The Cover

Cover image expansion

COVER This week's issue introduces a new name, Science Signaling, and a new volume number to the Signal Transduction Knowledge Environment, and features an Editorial Guide on breakthroughs in cell signaling of 2007. [Image: Christopher Bickel, AAAS]