Contents
Vol 1, Issue 1
Contents
Editorial Guide
- 2007: Signaling Breakthroughs of the Year
This year's advances span research into the signals that regulate the state of chromatin in the cell nucleus to those signals that modulate the social behavior of organisms.
Perspective
- Nuclear Ubiquitin Ligases, NF-κB Degradation, and the Control of Inflammation
The ubiquitination and degradation of NF-κB complexes in the nucleus provides a mechanism by which pro-inflammatory responses are terminated.
Editors' Choice
- An RGS for PI3K
Regulator of G protein signaling 13 (RGS13) interacts with the p85 subunit of PI3K to inhibit mast cell degranulation.
- Absence Makes the Wnt Go Stronger
Cells deficient in cilia exhibit enhanced responses to Wnt3a.
- Contraction-Mediated Release of TGF-β1
Integrin-mediated release of latent TGF-β1 from the extracellular matrix involves the mechanical stress of cell contraction.
- Reduced to Activation
Extracellular thioredoxin activates TRPC5 channels and heteromultimers by breaking a disulphide bridge.
- A STIM for Resting Cells
A key regulatory protein helps hold constant basal concentrations of calcium in the cell.
- Akirins Clarify NF-κB Signaling
A new nuclear player, Akirin, is discovered for the NF-κB pathway.
- Transporting Behavior?
Glial modulation of extracellular glutamate concentration and glutamatergic transmission affects male Drosophila courtship behavior.
- Changing Her Ways
Sex peptide receptor, a GPCR, mediates postmating changes in female behavior.
- Invasion Signal
GEP100, an activator of the small GTPase Arf6, mediates EGF-dependent tumor cell invasiveness.
- Synaptic Metaplasticity
During continuous sensory stimulation, NMDA receptors in the mouse cortex switch from enhancing synaptic potentiation to opposing it.
- The Ant and the Butterfly
Because they are coated with a specific chemical, the larvae of a butterfly are adopted and cared for by an ant species, a relationship that shows signs of ongoing coevolution.
