15 January 2008
Vol 1, Issue 2
  • Contents

    • Perspectives

    • Editors' Choice

      • Protons Keep Worms Regular

        Protons mediate signaling from intestinal cells to surrounding muscle in the worm.

      • NGF Targets Synaptotagmin 4

        JNK activation mediates nerve growth factor-enhanced secretion in PC12 cells.

      • Vision from Afar

        Ceramidase regulation of fly photoreceptor function is cell nonautonomous.

      • Controlling Tremor with Adenosine

        Deep brain stimulation appears to trigger nonsynaptic release of ATP, which when converted to adenosine contributes to the tremor-reducing effects of this treatment.

      • Expressing Estrogen-Responsive Genes

        Estrogens trigger histone demethylation, which elicits a local DNA oxidative burst that guides initial assembly of the transcription/repair complex.

      • Where the PS Is

        A fluorescent tag specific for a negatively charged lipid shows that its higher concentration in endosomes and lysosomes attracts cationic proteins within the cell.

      • EPCs at the Switch

        Experiments in mice show that certain bone marrow cells promote the development of lung cancers by helping blood vessels form within the tumors.

      • Cancer Antigens Uncovered

        In mice, a common histone protein that coats DNA is unexpectedly detected within prostate tumors by the immune system, suggesting a potential therapeutic approach.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on clustering of acetylcholine receptors at the developing neuromuscular junction. The image depicts the signals that organize acetylcholine receptors. [Image: Christopher Bickel, AAAS]