Contents
Vol 1, Issue 20
Contents
Perspective
- Focal Adhesion Kinase Versus p53: Apoptosis or Survival?
Focal adhesion kinase acts as a scaffold protein to target p53 for degradation in the nucleus, leading to cell proliferation.
Editors' Choice
- G Protein-Coupled Receptor Signaling in the Nucleus
Metabotropic glutamate receptors may trigger nuclear calcium signals through a G protein signaling pathway completely localized in the nucleus.
- Shaping Signals
Variations in cell shape can translate into distinct signaling patterns within a cell.
- Interfering with Inflammation
Interferon-β produced locally in the central nervous system acts on myeloid cells to protect against inflammation.
- Cadherins and Guidepost Neurons
A cadherin molecule on the surface of guidepost neurons in the developing brain marks the pathway for axons to follow from the thalamus to the cortex.
- Positive and Negative Glypicans
Glypican-3 in mammals appears to inhibit Hedgehog signaling, whereas in flies glypicans are required for Hedgehog signaling.
- A Polarized Viewpoint?
The crystal structure of squid rhodopsin sheds light on signaling through GPCRs that interact with Gq.
- Patterned by Smell
The morphology of primary cilia in a C. elegans olfactory neuron is shaped by sensory input.
- Notch Presents a Challenge
Notch signaling in CD8+ T cells increases inflammation and airway hyperresponsiveness in a mouse model of asthma.
- The Logic of Neurite Outgrowth
Analysis of transcription data and known signaling networks predicts two previously unrecognized regulators of neuronal growth, which were experimentally confirmed.
- Two-Way Adaptor
A focal adhesion component is required for both outside-in and inside-out integrin signaling.
- Signaling Clock Timing
Signaling through cyclic adenosine monophosphate determines the amplitude, phase, and period of the mammalian circadian clock and so may be an integral part of the pacemaker.
- Plant Responses to Salt Stress
In Arabidopsis root tips exposed to high salinity or iron deficiency, clusters of genes are induced that are unique to one or both of these stress responses.
