20 May 2008
Vol 1, Issue 20
  • Contents

    • Perspective

    • Editors' Choice

      • Shaping Signals

        Variations in cell shape can translate into distinct signaling patterns within a cell.

      • Interfering with Inflammation

        Interferon-β produced locally in the central nervous system acts on myeloid cells to protect against inflammation.

      • Cadherins and Guidepost Neurons

        A cadherin molecule on the surface of guidepost neurons in the developing brain marks the pathway for axons to follow from the thalamus to the cortex.

      • Positive and Negative Glypicans

        Glypican-3 in mammals appears to inhibit Hedgehog signaling, whereas in flies glypicans are required for Hedgehog signaling.

      • A Polarized Viewpoint?

        The crystal structure of squid rhodopsin sheds light on signaling through GPCRs that interact with Gq.

      • Patterned by Smell

        The morphology of primary cilia in a C. elegans olfactory neuron is shaped by sensory input.

      • Notch Presents a Challenge

        Notch signaling in CD8+ T cells increases inflammation and airway hyperresponsiveness in a mouse model of asthma.

      • The Logic of Neurite Outgrowth

        Analysis of transcription data and known signaling networks predicts two previously unrecognized regulators of neuronal growth, which were experimentally confirmed.

      • Two-Way Adaptor

        A focal adhesion component is required for both outside-in and inside-out integrin signaling.

      • Signaling Clock Timing

        Signaling through cyclic adenosine monophosphate determines the amplitude, phase, and period of the mammalian circadian clock and so may be an integral part of the pacemaker.

      • Plant Responses to Salt Stress

        In Arabidopsis root tips exposed to high salinity or iron deficiency, clusters of genes are induced that are unique to one or both of these stress responses.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses how the tyrosine kinase focal adhesion kinase (FAK) acts in a kinase-independent manner as a scaffold protein to lead to the degradation of the tumor suppressor protein p53 in the nucleus. The image depicts the degradation of p53 (in orange) by the nuclear proteasome. [Image: Chris Bickel, AAAS]