27 May 2008
Vol 1, Issue 21
  • Contents

    • Editorial Guide

    • Perspectives

    • Editors' Choice

      • Determining Pathway Bandwidth

        A microfluidic device allows calculation of the frequency at which a pathway can faithfully reproduce an input and above which the pathway integrates the input.

      • Getting the Numbers Right

        The large number of CD3 ITAM motifs contained within the T cell receptor complex is needed to prevent autoimmunity.

      • Stages of TLR Signaling

        IRAK4 initiates the response to Toll-like receptor (TLR) signaling, then IRAK1 mediates a transient early phase and IRAK2 mediates a prolonged late phase.

      • Degrading Polyamines for Migration

        Polyamine regulation of a potassium channel is implicated in migration mediated by α9-containing integrins.

      • Reorganizing Dendrites

        The effects of estradiol on hypothalamic dendritic morphology involve enhancement of presynaptic glutamate release through nongenomic mechanisms.

      • Traffic Control for Oocytes

        Altered intracellular trafficking of a receptor for sperm protein is implicated in control of meiotic maturation of oocytes in C. elegans.

      • Route to Specificity

        Activation of Gln3 occurs by two distinct mechanisms, one of which depends on its intracellular localization.

      • Two Clocks Are Better Than One

        When hungry, rodents may optimize their chances of finding food by engaging a food-entrained circadian clock in the brain that takes over from the light-driven clock.

      • Unmasking the Sensor of Iron Deficiency

        A cell-surface enzyme that cleaves proteins is unexpectedly necessary for sensing when iron levels are low and thereby triggering compensatory absorption of iron from food.

      • Regulating S-Nitrosylation

        Thioredoxins--known to be antioxidants--also remove nitrosyl groups from a protease to activate it and may also function in this way in other cellular regulatory systems.

About The Cover

Cover image expansion

COVER This week's Focus Issue, in conjunction with Science's Special Issue on Microbial Ecology, features an Editorial Guide and three Perspectives that discuss how interactions between microbes and their hosts affect signaling pathways in the host. The image shows grape leaves suffering from Pierce's disease, which is caused by the bacterium Xylella fastidiosa. [Image: Fritz Westover, Texas A & M University, Texas Cooperative Extension.]