Contents
Vol 1, Issue 21
Contents
Editorial Guide
- Focus Issue: A Niche of One’s Own
The nature of microbe-host relationships often depends on signaling pathways in the host.
Perspectives
- Diversification of the Function of Cell-to-Cell Signaling in Regulation of Virulence Within Plant Pathogenic Xanthomonads
Different plant pathogens use similar signaling molecules in distinct ways.
- Bacterial-Modulated Signaling Pathways in Gut Homeostasis
Stimulation of the production of reactive oxygen species in gut epithelial cells by commensal bacteria dampens the host immune response.
- ETosis: A Novel Cell Death Pathway
Pathogenic microbes are trapped and killed by mast cell– and neutrophil-derived extracellular traps.
Editors' Choice
- Determining Pathway Bandwidth
A microfluidic device allows calculation of the frequency at which a pathway can faithfully reproduce an input and above which the pathway integrates the input.
- Getting the Numbers Right
The large number of CD3 ITAM motifs contained within the T cell receptor complex is needed to prevent autoimmunity.
- Stages of TLR Signaling
IRAK4 initiates the response to Toll-like receptor (TLR) signaling, then IRAK1 mediates a transient early phase and IRAK2 mediates a prolonged late phase.
- Degrading Polyamines for Migration
Polyamine regulation of a potassium channel is implicated in migration mediated by α9-containing integrins.
- Reorganizing Dendrites
The effects of estradiol on hypothalamic dendritic morphology involve enhancement of presynaptic glutamate release through nongenomic mechanisms.
- Traffic Control for Oocytes
Altered intracellular trafficking of a receptor for sperm protein is implicated in control of meiotic maturation of oocytes in C. elegans.
- Route to Specificity
Activation of Gln3 occurs by two distinct mechanisms, one of which depends on its intracellular localization.
- Two Clocks Are Better Than One
When hungry, rodents may optimize their chances of finding food by engaging a food-entrained circadian clock in the brain that takes over from the light-driven clock.
- Unmasking the Sensor of Iron Deficiency
A cell-surface enzyme that cleaves proteins is unexpectedly necessary for sensing when iron levels are low and thereby triggering compensatory absorption of iron from food.
- Regulating S-Nitrosylation
Thioredoxins--known to be antioxidants--also remove nitrosyl groups from a protease to activate it and may also function in this way in other cellular regulatory systems.
