Contents
Vol 1, Issue 22
Contents
Perspective
- Steering in Quadruplet: The Complex Signaling Pathways Directing Chemotaxis
Multiple pathways act in concert to direct a cell's migration.
Review
- Pharmacological PKA Inhibition: All May Not Be What It Seems
Widely used inhibitors of cAMP-dependent protein kinase (PKA) have nonspecific side effects.
Editors' Choice
- Antisense Boosts EPO Receptors
The production of erythropoietin receptors appears to be enhanced in the presence of antisense transcripts from the receptor-encoding gene.
- Allies from Within
A bacterial polysaccharide can protect against inflammatory bowel disease.
- Right Time, Right Place
In mice infected with herpes virus, a usually immunosuppressive T cell is necessary for rapid arrival of immune cells and elevated cytokine levels at the site of infection.
- Another Way to Die
In the absence of p53 and the kinase Chk1, DNA damage triggers cell death through a caspase-2-dependent mechanism.
- More Than One Way to Skin a Kinase
The adaptor protein Csk-binding protein (Cbp) recruits c-Src to lipid rafts and inhibits c-Src-mediated cellular transformation independently of Csk.
- Activate or Repress?
The DNA sequence of a TCF-binding site allosterically determines whether the TCF-Armadillo complex activates or represses gene transcription.
- Algae Present a New Cell Cycle Paradigm
Mitosis in the brown alga Fucus is not dependent on a morphogenesis checkpoint.
- Micro Managing Translational Repression
Plant microRNAs and small interfering RNAs, thought to inhibit gene expression by cleavage of their RNA targets, also interfere with the translation of these RNAs into protein.
Erratum
