Contents
Vol 1, Issue 23
Contents
Perspectives
- ROCO Kinase Activity Is Controlled by Internal GTPase Function
The guanosine triphosphatase (GTPase) domain of leucine-rich repeat kinase 2 (LRRK2) mediates LRRK2 homodimerization and controls its protein kinase activity.
- Dual Functions of the KNOTTED1 Homeodomain: Sequence-Specific DNA Binding and Regulation of Cell-to-Cell Transport
A single domain confers different subcellular localizations of the homeodomain protein KN1.
Teaching Resource
- Physiological and Pathological Actions of Calpains in Glutamatergic Neurons
This pair of animations illustrates how neuronal calpains contribute to synaptic plasticity or neuronal toxicity.
Editors' Choice
- Lyn for Growth Hormone Receptor
The kinase Lyn provides a pathway from the growth hormone receptor to extracellular signal-regulated kinase that is independent of the kinase Jak.
- A SUMOylated Energy Switch
Ligand stimulation of PPAR-δ triggers KLF5 deSUMOylation, leading to the transcriptional activation of genes involved in lipid oxidation and energy uncoupling.
- Sumoylating TGF-β Receptors
The type I subunit of the transforming growth factor-β receptor may be sumoylated.
- NF-κB Links Immunity to the Hypoxic Response
NF-κB activity is required for basal and hypoxia-induced transcription of the gene encoding HIF-1α.
- Separate and Equal?
A signaling pathway that regulates stem cell proliferation in Arabidopsis is independently transduced through two different receptor complexes.
- Pathway Evolution
Some bacterial signaling networks are composed of modules of genes that coevolve.
- Foresight Among E. coli
Predictable sequences of environmental signals can be exploited by bacteria so that they learn to anticipate future metabolic needs and thereby gain a competitive edge.
- Modular Morphology
A developmental program in Ciona intestinalis suggests a mechanism by which morphological diversity could be generated.
- Signaling in Space
T cells are differentially affected by distinct spatial presentation of ligands.
