10 June 2008
Vol 1, Issue 23
  • Contents

    • Perspectives

    • Teaching Resource

    • Editors' Choice

      • Lyn for Growth Hormone Receptor

        The kinase Lyn provides a pathway from the growth hormone receptor to extracellular signal-regulated kinase that is independent of the kinase Jak.

      • A SUMOylated Energy Switch

        Ligand stimulation of PPAR-δ triggers KLF5 deSUMOylation, leading to the transcriptional activation of genes involved in lipid oxidation and energy uncoupling.

      • Sumoylating TGF-β Receptors

        The type I subunit of the transforming growth factor-β receptor may be sumoylated.

      • Separate and Equal?

        A signaling pathway that regulates stem cell proliferation in Arabidopsis is independently transduced through two different receptor complexes.

      • Pathway Evolution

        Some bacterial signaling networks are composed of modules of genes that coevolve.

      • Foresight Among E. coli

        Predictable sequences of environmental signals can be exploited by bacteria so that they learn to anticipate future metabolic needs and thereby gain a competitive edge.

      • Modular Morphology

        A developmental program in Ciona intestinalis suggests a mechanism by which morphological diversity could be generated.

      • Signaling in Space

        T cells are differentially affected by distinct spatial presentation of ligands.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses how the GTPase domain of leucine-rich repeat kinase 2 (LRRK2) mediates LRRK2 homodimerization and controls its protein kinase activity. The image shows the structure of the dimeric GTPase domains of human LRRK2, with one monomer in yellow and the other in green, and is based on PDB structure 2ZEJ. [Image: Bertram Weiss, Bayer Schering Pharma AG13342, Berlin, Germany.]