17 June 2008
Vol 1, Issue 24
  • Contents

    • Perspectives

    • Podcast

      • Science Signaling Podcast: 17 June 2008

        Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype.

    • Editors' Choice

      • Receptor Rendezvous

        Receptors mediating antiviral responses of the innate and adaptive immune systems act together in an autophagosome-like cellular compartment.

      • Macrophages Go Back to School

        "Retraining" macrophages to inhibit their NF-κB activity leads to improved responses against tumors and invading bacteria.

      • Linking Light to Development and Metabolism

        Some of the molecular machinery through which light inhibits secondary metabolism and sexual reproduction in fungi has been identified.

      • Src Family Kinase for Wnt5 Signaling

        A complex of Src64B and the RYK receptor Derailed appears to be important for Wnt5-mediated axonal repulsion in the developing fly nervous system.

      • New Eph Receptor Ligand

        VAPB serves as a ligand for Eph receptors, and a mutation in humans that prevents release of this protein and promotes its aggregation is associated with amyotrophic lateral sclerosis.

      • Location Matters

        Nutrients, specifically amino acids, are sensed by small GTPases, which bind to a signaling complex, moving it close to the nucleus, where it initiates cell growth.

      • Mapping the Yeast Protein Interaction Network

        A method that identifies pairs of proteins that are 8 nanometers apart produces a map of interacting proteins in living yeast, finding known and previously unknown networks.

      • Damage Detection

        Protein complexes that usually assemble on and repair damaged DNA can form at undamaged sites to halt the cell cycle if several of the proteins are first tethered there.

      • Fat Controller

        In mice, a transcription factor known to participate in secretion is also necessary for induction of lipid synthesis by carbohydrates in the liver.

      • Cold Turkey and MAP Kinase

        Activation of the mitogen-activated protein kinase pathway in a specific brain region specifically decreases alcohol-drinking behaviors in mice.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses how the von Hippel-Lindau tumor suppressor protein (pVHL) controls both transcription-dependent and transcription-independent cellular processes. The image shows the structure of pVHL (blue) in a complex with the proteins Elongins B and C and is based on PDB structure 1VCB. [Image: Chris Bickel, AAAS]