Contents
Vol 1, Issue 25
Contents
Perspectives
- Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?
Are calcium signaling pathways in the heart regulated by bulk cytoplasmic calcium or by calcium in specialized microdomains?
- A Cunning Stunt: An Alternative Mechanism of Eukaryotic Translation Initiation
Translation of cellular inhibitor of apoptosis 2 transcripts appears to involve a ribosome shunting mechanism, permitting translation in periods of stress.
Review
- Dissociation of Heterotrimeric G Proteins in Cells
G proteins may function as activated heterotrimers, as well as dissociated subunits.
Editors' Choice
- Counting Phosphates
The DNA-damage-response kinase Dun1 must bind, through its FHA domain, to not one, but two phosphothreonine residues to be activated by the kinase Rad53.
- Regulating the Regulators
Mitosis begins in mammalian cells when a protein accumulates between cell divisions and interacts with a second protein to initiate a cascade of kinase activation.
- β3 Integrin as a Coreceptor for TLR2
Vitronectin appears to bind bacterial lipopeptides to present these to a complex of integrins with β3 subunits and Toll-like receptor 2.
- Sometimes Less Is More
T cell activation induces the production of mRNAs with shorter 3′UTRs and fewer microRNA target sites.
- Plant Hair Signals
Movement between cells appears to drive the accumulation of the protein TTG1 into the cells that form trichomes, while depleting neighboring cells.
- Glial Cell Tuning
Astrocytes in the visual cortex respond to visual stimuli, showing receptive field properties (response kinetics, orientation, and localization) similar to those of neurons.
