01 July 2008
Vol 1, Issue 26
  • Contents

    • Perspectives

    • Editors' Choice

      • Anesthesia Increases Postoperative Pain

        Some volatile and intravenous general anesthetics activate TRPA1 channels to trigger peripheral pain and nerve-mediated inflammation.

      • Enhancing Channel Activity

        Mutant presenilin proteins, which are associated with familial Alzheimer’s disease, enhance IP3 receptor–mediated Ca2+ signaling in neurons.

      • A Ligand, Not a Carrier

        The odorant-binding protein LUSH appears to be an inactive ligand activated by pheromone binding.

      • Making Animals the Right Size

        Shuttling of morphogens with different affinities for an inhibitor and a negative feedback loop for the morphogen with lower affinity allows Xenopus embryos to scale pattern with size.

      • Polarity Proteins Get Excluded

        Establishment of radial polarity in the early C. elegans embryo requires a RhoGAP that is active only in regions of cell contact.

      • Developing the Lateral Line

        A fish sensory organ develops when a wave of migrating primordial cells cyclically deposits rosettes of differentiated cells under the influence of fibroblast growth factor.

      • Expanding β-Arrestin’s Remit

        β-arrestins appear to link the Hedgehog receptor protein Smoothened to a motor protein that helps transport the receptor to the primary cilium.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses the role of Sonic hedgehog (Shh) in promoting the proliferation of mesenchymal cells that give rise to digits in the developing limb. The image shows the anterior and posterior digits that form in the chick limb. [Image: Craig Nicol, MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK]