08 July 2008
Vol 1, Issue 27
  • Contents

    • Perspective

    • Review

    • Editors' Choice

      • Smad-Dependent MicroRNA Processing

        Ligand-specific R-Smads interact with the primary miR-21 transcripts and the DROSHA complex to stimulate processing to the mature miRNA.

      • Breaking Through the Basement

        Decreased activity of RhoA and destabilization of basal microtubules lead to basement membrane breakdown at the onset of the epithelial-mesenchymal transition during gastrulation.

      • Starved into Action

        Fibroblast growth factor 21 (FGF21), a hormone whose production is triggered by fasting, inhibits growth hormone signaling.

      • Nuclear GAPDH Triggers Apoptosis

        Nitrosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) leads to its nuclear translocation and the stimulation of nuclear protein acetyltransferases to contribute to apoptosis.

      • Spreading the Word

        When strengthened, individual synapses on dendritic spines contain an activated small regulatory protein, which spreads to nearby spines, possibly altering their sensitivity.

      • Generating a Biological Oscillator

        Analysis of known and theoretical oscillatory circuits in cells shows that those with both negative and positive feedback are more robust and allow frequency control independent of amplitude.

      • Myosins Under Tension

About The Cover

Cover image expansion

COVER This week's issue features a Review that discusses the metalloproteinase-independent functions of tissue inhibitors of metalloproteinases (TIMPs). The image shows how the binding of TIMP-2 (pink) to the α3β4 integrin inhibits receptor tyrosine kinase activity through the action of the protein tyrosine phosphatase Shp1. [Image: Chris Bickel, AAAS]