15 July 2008
Vol 1, Issue 28
  • Contents

    • Review

      • Ethanol’s Molecular Targets

        Ethanol affects the functions of specific proteins through its interaction with a select few amino acids in those proteins.

    • Podcast

    • Editors' Choice

      • Chromosomes Get Together

        Interactions between chromosomes, which depend on the transcription factor NF-κB, trigger monoallelic expression of IFN-β in response to viral infection.

      • Bone Disease from a Placental Hypoxia Pathway

        Disruption of leukemia inhibitory factor (LIF) signaling in the placenta leads to hypoxia and subsequent formation of giant osteoclasts.

      • Positive Repression

        Under basal conditions, the tumor suppressor protein p53 prevents tumorigenesis by suppressing CD44 gene expression.

      • Heading in the Wrong Direction?

        Alterations in dopamine efflux through the presynaptic transporter may play a role in attentiondeficit hyperactivity disorder.

      • Maintaining Cerebrovascular Integrity

        Targeting signaling mediated through PDGF-CC and PDGFR-α may extend the therapeutic window for tPA treatment of ischemic stroke.

      • Finding and Building Connections

        EphB2 appears to play a dendritic motility role and a presynaptic stabilization role in mouse excitatory synaptogenesis.

      • Resist or Persist

        A small molecule produced by a common pathogenic bacterium inhibits the activity of a key immune transcription factor.

      • Know Thyself

        The ability of clones of a pathogenic bacterium to distinguish themselves from one another resides in a six-gene locus with interrelated recognition functions.

      • Stopping STIM Stops Strokes

        Lack of the calcium sensor protein STIM1 makes platelets less likely to contribute to clots that might lead to stroke.

    • Erratum

About The Cover

Cover image expansion

COVER This week's issue features a Review that describes how ethanol affects the functions of proteins such as enzymes and ion channels by binding to specific amino acid residues in these targets. The image shows the binding of ethanol in a cavity between two α helices in a target receptor. [Image: James R. Trudell, Stanford University School of Medicine]