22 July 2008
Vol 1, Issue 29
  • Contents

    • Review

    • Editors' Choice

      • A Virulent Response to Losing Your Tail

        Signals encountered in the intestine may enable V. cholerae to express virulence factors at precisely the right time and place.

      • Facilitating Multicellularity

        The emergence of tyrosine kinase signaling systems coincides with the emergence of multicellularity and may have evolved from serine-threonine kinase systems.

      • Positive Peroxidation

        Lipid peroxidation products of ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) prevent inflammation by inhibiting NF-κB signaling.

      • More Feedback Keeps It Going

        Analysis of single cells reveals two positive feedback loops in driving cells to divide.

      • Phosphorylation Inside-Out

        A newly described type of protein kinase found in the Golgi phosphorylates signaling proteins on amino acids that are destined to be within extracellular domains.

      • Sleepless in Drosophila

        A search for genetic modulators of sleep in Drosophila identified a gene encoding a brain protein that is likely secreted and is required for recovery from sleep deprivation.

      • Nailing a Riboswitch

        The bacterial second messenger cyclic di-GMP controls a wide variety of cellular functions by acting on a riboswitch motif in numerous mRNAs.

      • Doubled-Up Decision

        Two transcription factors cooperate to ensure the correct functioning of CD8+ T cells during the response to infection.

      • Dead but Not Deadly

        Oxidation of an immunogenic protein during apoptosis helps apoptotic cells avoid activating the adaptive immune system.

About The Cover

Cover image expansion

COVER This week's issue features a Review that describes a new method of drug discovery that focuses on those host proteins that are targeted by a given pathogen because they are essential to that pathogen's infection strategy. The image shows Listeria, one of the pathogens discussed in the Review. [Image: PHOTOTAKE Inc./Alamy]