22 January 2008
Vol 1, Issue 3
  • Contents

    • Perspective

    • Editors' Choice

      • Pass on the Salt

        The mechanism that regulates basal blood pressure is distinct from that which modulates salt-induced hypertension.

      • Cycling in Synchrony

        Bone morphogenetic proteins regulate and coordinate regional hair follicle cycling.

      • Heads or Tails

        After the head or tail of a planaria is severed, the signal intensity of a prominent developmental signaling pathway controls whether a new head or tail regenerates.

      • Organizing Brain Development

        The brain's cortex begins as a one-cell-thick sheet of stem cells whose ultimate identity is specified by a gene that suppresses noncortical cell fates.

      • Tumor Suppressor Yin-Yang

        An important developmental signaling molecule known to be a tumor suppressor can also activate growth, possibly explaining the responses of some cancers.

      • LMP1 Subverts "TRADDitional" Signals

        Epstein-Barr virus LMP1 protein hijacks the TNF receptor adaptor protein TRADD to block apoptosis of infected cells.

      • An Exception to the Trimer Paradigm

        Mouse glucocorticoid-induced tumor necrosis factor receptor ligand (GITRL) adopts a dimeric structure, whereas all other known TNF family members are trimers.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on the role of the endoplasmic reticulum (ER) in regulating the localization of cell cycle proteins. The image depicts proteins leaving the ER surface. [Image: Christopher Bickel, AAAS]